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Article: Does radiotherapy increase oxidative stress? A study with nasopharyngeal cancer patients revealing anomalies in isoprostanes measurements

TitleDoes radiotherapy increase oxidative stress? A study with nasopharyngeal cancer patients revealing anomalies in isoprostanes measurements
Authors
Issue Date2010
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/10715762.asp
Citation
Free Radical Research, 2010, v. 44 n. 9, p. 1064-1071 How to Cite?
AbstractThis study aimed to examine if exposure to ionizing radiation during clinical radiotherapy (RT) causes increased oxidative damage. Seven patients with nasopharyngeal cancer (NPC) who underwent RT took part in this controlled-trial study. Blood and urine samples were obtained for F 2-isoprostanes (F 2-IsoPs) measurement. Urinary F 2-IsoPs levels were elevated pre-treatment and remained high (but did not increase) during treatment, but decreased to the normal range after treatment. Plasma F 2-IsoPs decreased significantly after the start of treatment before rising midway through treatment. Levels decreased significantly to below baseline following treatment. However, the patients were observed to have substantially lower levels of plasma esterified arachidonic acid (AA) residues than controls. The data shows that NPC is associated with elevated F 2-isoprostanes in urine and in plasma after correction for decreased AA levels. RT did not increase these levels and, indeed, was associated with falls in F 2-IsoPs. The validity and usefulness of correction of plasma F 2-IsoPs for lowered AA levels is discussed. © 2010 Informa UK Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/179209
ISSN
2015 Impact Factor: 2.949
2015 SCImago Journal Rankings: 1.159
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLim, KHCen_US
dc.contributor.authorLee, CYJen_US
dc.contributor.authorEarnest, Aen_US
dc.contributor.authorSeet, RCSen_US
dc.contributor.authorHalliwell, Ben_US
dc.date.accessioned2012-12-19T09:52:56Z-
dc.date.available2012-12-19T09:52:56Z-
dc.date.issued2010en_US
dc.identifier.citationFree Radical Research, 2010, v. 44 n. 9, p. 1064-1071en_US
dc.identifier.issn1071-5762en_US
dc.identifier.urihttp://hdl.handle.net/10722/179209-
dc.description.abstractThis study aimed to examine if exposure to ionizing radiation during clinical radiotherapy (RT) causes increased oxidative damage. Seven patients with nasopharyngeal cancer (NPC) who underwent RT took part in this controlled-trial study. Blood and urine samples were obtained for F 2-isoprostanes (F 2-IsoPs) measurement. Urinary F 2-IsoPs levels were elevated pre-treatment and remained high (but did not increase) during treatment, but decreased to the normal range after treatment. Plasma F 2-IsoPs decreased significantly after the start of treatment before rising midway through treatment. Levels decreased significantly to below baseline following treatment. However, the patients were observed to have substantially lower levels of plasma esterified arachidonic acid (AA) residues than controls. The data shows that NPC is associated with elevated F 2-isoprostanes in urine and in plasma after correction for decreased AA levels. RT did not increase these levels and, indeed, was associated with falls in F 2-IsoPs. The validity and usefulness of correction of plasma F 2-IsoPs for lowered AA levels is discussed. © 2010 Informa UK Ltd.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/10715762.aspen_US
dc.relation.ispartofFree Radical Researchen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCarcinoma - Blood - Radiotherapy - Urineen_US
dc.subject.meshDose Fractionationen_US
dc.subject.meshF2-Isoprostanes - Analysis - Blood - Urineen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNasopharyngeal Neoplasms - Blood - Radiotherapy - Urineen_US
dc.subject.meshOxidative Stress - Radiation Effectsen_US
dc.subject.meshRadiation Injuries - Blood - Epidemiology - Urineen_US
dc.subject.meshRadiotherapy - Adverse Effectsen_US
dc.subject.meshUp-Regulation - Radiation Effectsen_US
dc.titleDoes radiotherapy increase oxidative stress? A study with nasopharyngeal cancer patients revealing anomalies in isoprostanes measurementsen_US
dc.typeArticleen_US
dc.identifier.emailLee, CYJ: jettylee@hku.hken_US
dc.identifier.authorityLee, CYJ=rp01511en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.3109/10715762.2010.499906en_US
dc.identifier.pmid20815769-
dc.identifier.scopuseid_2-s2.0-77956362404en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77956362404&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume44en_US
dc.identifier.issue9en_US
dc.identifier.spage1064en_US
dc.identifier.epage1071en_US
dc.identifier.isiWOS:000282185800010-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLim, KHC=15069324000en_US
dc.identifier.scopusauthoridLee, CYJ=13104265200en_US
dc.identifier.scopusauthoridEarnest, A=6603854036en_US
dc.identifier.scopusauthoridSeet, RCS=10045357300en_US
dc.identifier.scopusauthoridHalliwell, B=7101878919en_US

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