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Article: Ethoxyresorufin-O-deethylase enzyme activities and accumulation of secondary/tertiary lysosomes in rabbitfish Siganus oramin as biomarkers for xenobiotic exposures

TitleEthoxyresorufin-O-deethylase enzyme activities and accumulation of secondary/tertiary lysosomes in rabbitfish Siganus oramin as biomarkers for xenobiotic exposures
Authors
Issue Date2010
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/scitotenv
Citation
Science Of The Total Environment, 2010, v. 408 n. 20, p. 4833-4840 How to Cite?
AbstractThe sensitivities of using hepatic and intestinal ethoxyresorufin-. O-deethylase (EROD) activities and hepatic accumulation of secondary/tertiary (2°/3°) lysosomes to detect xenobiotic exposures were assessed in the rabbitfish Siganus oramin in a metropolitan harbour, subtropical Hong Kong, over a complete seasonal cycle of one year. Additional information on the body-burden pollutants and physiological indices in S. oramin, and seasonal variables in seawater quality, were extracted from published data and re-analyzed. Under the influences of pollutant cocktail and seasonal factors, neither the hepatic nor intestinal EROD activity was indicative of total polycyclic aromatic hydrocarbons (σ PAH), total polychlorinated biphenyls, condition factor and hepatosomatic index (HSI) in S. oramin. However, the relative ratio of hepatic to intestinal EROD activities provided an indication to differentiate the xenobiotic intake route in the fish through diffusion via gills/skin or consumption of contaminated food. In addition, the elevated hepatic accumulation of 2°/3° lysosomes was closely associated with the dominant temporal trends of zinc and σ PAH, as well as reduced HSI, in S. oramin. Being minimally influenced by any investigated seasonal factors, the hepatic 2°/3° lysosomes in S. oramin was recommended as an effective biomarker of xenobiotic exposures and toxic effects for use in coastal pollution monitoring programmes. © 2010 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/179207
ISSN
2015 Impact Factor: 3.976
2015 SCImago Journal Rankings: 1.702
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFang, JKHen_US
dc.contributor.authorAu, DWTen_US
dc.contributor.authorChan, AKYen_US
dc.contributor.authorSo, LKYen_US
dc.contributor.authorLiu, Wen_US
dc.contributor.authorMok, HOLen_US
dc.contributor.authorYu, WYen_US
dc.contributor.authorWu, RSSen_US
dc.contributor.authorShin, PKSen_US
dc.date.accessioned2012-12-19T09:52:55Z-
dc.date.available2012-12-19T09:52:55Z-
dc.date.issued2010en_US
dc.identifier.citationScience Of The Total Environment, 2010, v. 408 n. 20, p. 4833-4840en_US
dc.identifier.issn0048-9697en_US
dc.identifier.urihttp://hdl.handle.net/10722/179207-
dc.description.abstractThe sensitivities of using hepatic and intestinal ethoxyresorufin-. O-deethylase (EROD) activities and hepatic accumulation of secondary/tertiary (2°/3°) lysosomes to detect xenobiotic exposures were assessed in the rabbitfish Siganus oramin in a metropolitan harbour, subtropical Hong Kong, over a complete seasonal cycle of one year. Additional information on the body-burden pollutants and physiological indices in S. oramin, and seasonal variables in seawater quality, were extracted from published data and re-analyzed. Under the influences of pollutant cocktail and seasonal factors, neither the hepatic nor intestinal EROD activity was indicative of total polycyclic aromatic hydrocarbons (σ PAH), total polychlorinated biphenyls, condition factor and hepatosomatic index (HSI) in S. oramin. However, the relative ratio of hepatic to intestinal EROD activities provided an indication to differentiate the xenobiotic intake route in the fish through diffusion via gills/skin or consumption of contaminated food. In addition, the elevated hepatic accumulation of 2°/3° lysosomes was closely associated with the dominant temporal trends of zinc and σ PAH, as well as reduced HSI, in S. oramin. Being minimally influenced by any investigated seasonal factors, the hepatic 2°/3° lysosomes in S. oramin was recommended as an effective biomarker of xenobiotic exposures and toxic effects for use in coastal pollution monitoring programmes. © 2010 Elsevier B.V.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/scitotenven_US
dc.relation.ispartofScience of the Total Environmenten_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiological Markers - Metabolismen_US
dc.subject.meshCytochrome P-450 Cyp1a1 - Metabolismen_US
dc.subject.meshEnvironmental Monitoring - Methodsen_US
dc.subject.meshIntestines - Drug Effects - Enzymologyen_US
dc.subject.meshLiver - Drug Effects - Enzymologyen_US
dc.subject.meshLysosomes - Drug Effects - Enzymology - Metabolismen_US
dc.subject.meshPerciformes - Metabolismen_US
dc.subject.meshSeasonsen_US
dc.subject.meshToxicity Testsen_US
dc.subject.meshWater Pollutants, Chemical - Toxicityen_US
dc.subject.meshXenobiotics - Toxicityen_US
dc.titleEthoxyresorufin-O-deethylase enzyme activities and accumulation of secondary/tertiary lysosomes in rabbitfish Siganus oramin as biomarkers for xenobiotic exposuresen_US
dc.typeArticleen_US
dc.identifier.emailWu, RSS: rudolfwu@hku.hken_US
dc.identifier.authorityWu, RSS=rp01398en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.scitotenv.2010.06.003en_US
dc.identifier.pmid20630567-
dc.identifier.scopuseid_2-s2.0-77955918580en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77955918580&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume408en_US
dc.identifier.issue20en_US
dc.identifier.spage4833en_US
dc.identifier.epage4840en_US
dc.identifier.isiWOS:000281931500064-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridFang, JKH=24168119000en_US
dc.identifier.scopusauthoridAu, DWT=7004909228en_US
dc.identifier.scopusauthoridChan, AKY=24278666900en_US
dc.identifier.scopusauthoridSo, LKY=7007150474en_US
dc.identifier.scopusauthoridLiu, W=26664155200en_US
dc.identifier.scopusauthoridMok, HOL=7005842490en_US
dc.identifier.scopusauthoridYu, WY=36060650700en_US
dc.identifier.scopusauthoridWu, RSS=7402945079en_US
dc.identifier.scopusauthoridShin, PKS=7004445653en_US

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