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Article: 3,3',4,5,5'-pentahydroxy-trans-stilbene, a resveratrol derivative, induces apoptosis in colorectal carcinoma cells via oxidative stress

Title3,3',4,5,5'-pentahydroxy-trans-stilbene, a resveratrol derivative, induces apoptosis in colorectal carcinoma cells via oxidative stress
Authors
Issue Date2010
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 2010, v. 637 n. 1-3, p. 55-61 How to Cite?
AbstractResveratrol exhibits anti-tumor properties against different types of cancer. In this study, several polyhydroxylated resveratrol derivatives were prepared with the aim of discovering new leading compounds with clinical potential for human colon cancer chemotherapy. Among these compounds, 3,3',4,5,5'-pentahydroxy-. trans-stilbene (PHS) displayed the most potent cytotoxicity and triggered apoptosis in HT-29 cells as evidenced by increased poly(ADP-ribose) polymerase (PARP) cleavage, elevated levels of cytoplasmic nucleosomes and DNA fragmentation. Further mechanistic analysis revealed that PHS-induced apoptosis was caspase-dependent and mediated by its pro-oxidative action through up-regulation of reactive oxidative species generation and depletion of intracellular glutathione. © 2010 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/179191
ISSN
2015 Impact Factor: 2.73
2015 SCImago Journal Rankings: 1.115
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Hen_US
dc.contributor.authorWu, WKKen_US
dc.contributor.authorZheng, Zen_US
dc.contributor.authorChe, CTen_US
dc.contributor.authorLi, ZJen_US
dc.contributor.authorXu, DDen_US
dc.contributor.authorWong, CCMen_US
dc.contributor.authorYe, CGen_US
dc.contributor.authorSung, JJYen_US
dc.contributor.authorCho, CHen_US
dc.contributor.authorWang, Men_US
dc.date.accessioned2012-12-19T09:52:44Z-
dc.date.available2012-12-19T09:52:44Z-
dc.date.issued2010en_US
dc.identifier.citationEuropean Journal Of Pharmacology, 2010, v. 637 n. 1-3, p. 55-61en_US
dc.identifier.issn0014-2999en_US
dc.identifier.urihttp://hdl.handle.net/10722/179191-
dc.description.abstractResveratrol exhibits anti-tumor properties against different types of cancer. In this study, several polyhydroxylated resveratrol derivatives were prepared with the aim of discovering new leading compounds with clinical potential for human colon cancer chemotherapy. Among these compounds, 3,3',4,5,5'-pentahydroxy-. trans-stilbene (PHS) displayed the most potent cytotoxicity and triggered apoptosis in HT-29 cells as evidenced by increased poly(ADP-ribose) polymerase (PARP) cleavage, elevated levels of cytoplasmic nucleosomes and DNA fragmentation. Further mechanistic analysis revealed that PHS-induced apoptosis was caspase-dependent and mediated by its pro-oxidative action through up-regulation of reactive oxidative species generation and depletion of intracellular glutathione. © 2010 Elsevier B.V.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_US
dc.relation.ispartofEuropean Journal of Pharmacologyen_US
dc.subject.meshAntineoplastic Agents - Chemistry - Pharmacologyen_US
dc.subject.meshApoptosis - Drug Effectsen_US
dc.subject.meshBlotting, Westernen_US
dc.subject.meshColorectal Neoplasms - Metabolism - Pathologyen_US
dc.subject.meshCytoplasm - Metabolismen_US
dc.subject.meshDna Fragmentation - Drug Effectsen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshGlutathione - Metabolismen_US
dc.subject.meshHt29 Cellsen_US
dc.subject.meshHumansen_US
dc.subject.meshNucleosomes - Metabolismen_US
dc.subject.meshOxidative Stress - Drug Effectsen_US
dc.subject.meshPoly(Adp-Ribose) Polymerases - Metabolismen_US
dc.subject.meshStilbenes - Chemistry - Pharmacologyen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.subject.meshUp-Regulation - Drug Effectsen_US
dc.title3,3',4,5,5'-pentahydroxy-trans-stilbene, a resveratrol derivative, induces apoptosis in colorectal carcinoma cells via oxidative stressen_US
dc.typeArticleen_US
dc.identifier.emailWang, M: mfwang@hku.hken_US
dc.identifier.authorityWang, M=rp00800en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ejphar.2010.04.009en_US
dc.identifier.pmid20399769-
dc.identifier.scopuseid_2-s2.0-77953288212en_US
dc.identifier.hkuros170512-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77953288212&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume637en_US
dc.identifier.issue1-3en_US
dc.identifier.spage55en_US
dc.identifier.epage61en_US
dc.identifier.isiWOS:000278878900008-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridLi, H=25958185900en_US
dc.identifier.scopusauthoridWu, WKK=18345422600en_US
dc.identifier.scopusauthoridZheng, Z=8451746600en_US
dc.identifier.scopusauthoridChe, CT=7102442768en_US
dc.identifier.scopusauthoridLi, ZJ=35170171500en_US
dc.identifier.scopusauthoridXu, DD=34881058900en_US
dc.identifier.scopusauthoridWong, CCM=26421493300en_US
dc.identifier.scopusauthoridYe, CG=36104628400en_US
dc.identifier.scopusauthoridSung, JJY=35405352400en_US
dc.identifier.scopusauthoridCho, CH=14067000400en_US
dc.identifier.scopusauthoridWang, M=7406691844en_US
dc.identifier.citeulike7083933-

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