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Article: Aloe arborescens preparation and liver health

TitleAloe arborescens preparation and liver health
Authors
KeywordsAloe Arborescens
Anti-Inflammatory Effects
Antidiabetic Effects
Antitumorigenic Effects
Liver
Issue Date2009
Citation
European Journal Of Oncology, 2009, v. 14 n. 2, p. 93-101 How to Cite?
AbstractAloe arborescens Miller var. natalensis Berger (so called as "ALOE") is traditionally valued herbal medicine for gastrointestinal complaints, skin injuries and burns. The different pharmacological and therapeutic activities of ALOE have been studied. ALOE extracts have been reported to show anti-inflammatory, antidiabetic and antitumorigenic effects. In F344 rats, ALOE has been shown to have beneficial effects against colorectal tumorigenesis and formation of liver preneoplastic lesions. The aim of this study was to evaluate the effects of oral intake of ALOE preparation (Aloe arborescens, honey and distillate) on liver health. For this purpose, we investigated the effect of oral ALOE supplementation on the splenic and hepatic cellular immune functions in mice and on dimethylnitrosamine (DMN) - induced liver fibrosis in rats. The studied immune parameters included the presence and cytokine production of different T-cell populations, including T-cell helper (CD4+) subpopulations (Th1, Th2, Th17 and Tregs), cytotoxic T-cells (CD8+) and Natural Killer T (NKT) cells as well as Natural Killer (NK) cells. The anti-fibrogenic potential of ALOE was evaluated based on hepatic stellate cells (HSCs) activation and apoptosis due to DMN treatment. The most evident immunological effect associated with ALOE supplementation was the reduced prevalence of splenic NKT cells (p=0.02). In addition, the treatment appeared to increase the total proportion of CD4+ cells among splenic T cells (p=0.03) and the interferon-γ production by hepatic Th1 cells (p=0.06) tented to increase. In DMN-treated rats, the ALOE supplementation reduced the hepatic hydroxyproline content and α-SMA expression and improved the histopathology compared to controls. These results indicate that ALOE administration may have immunomodulatory effects and lower the fibrogenic process in the liver.
Persistent Identifierhttp://hdl.handle.net/10722/179166
ISSN
2013 Impact Factor: 0.22
2015 SCImago Journal Rankings: 0.101
References

 

DC FieldValueLanguage
dc.contributor.authorAnwar, WAen_US
dc.contributor.authorKirjavainen, PVen_US
dc.contributor.authorIsola, Jen_US
dc.contributor.authorEl Zarka, Men_US
dc.contributor.authorSpiros, TMen_US
dc.contributor.authorElNezami, Hen_US
dc.date.accessioned2012-12-19T09:52:30Z-
dc.date.available2012-12-19T09:52:30Z-
dc.date.issued2009en_US
dc.identifier.citationEuropean Journal Of Oncology, 2009, v. 14 n. 2, p. 93-101en_US
dc.identifier.issn1128-6598en_US
dc.identifier.urihttp://hdl.handle.net/10722/179166-
dc.description.abstractAloe arborescens Miller var. natalensis Berger (so called as "ALOE") is traditionally valued herbal medicine for gastrointestinal complaints, skin injuries and burns. The different pharmacological and therapeutic activities of ALOE have been studied. ALOE extracts have been reported to show anti-inflammatory, antidiabetic and antitumorigenic effects. In F344 rats, ALOE has been shown to have beneficial effects against colorectal tumorigenesis and formation of liver preneoplastic lesions. The aim of this study was to evaluate the effects of oral intake of ALOE preparation (Aloe arborescens, honey and distillate) on liver health. For this purpose, we investigated the effect of oral ALOE supplementation on the splenic and hepatic cellular immune functions in mice and on dimethylnitrosamine (DMN) - induced liver fibrosis in rats. The studied immune parameters included the presence and cytokine production of different T-cell populations, including T-cell helper (CD4+) subpopulations (Th1, Th2, Th17 and Tregs), cytotoxic T-cells (CD8+) and Natural Killer T (NKT) cells as well as Natural Killer (NK) cells. The anti-fibrogenic potential of ALOE was evaluated based on hepatic stellate cells (HSCs) activation and apoptosis due to DMN treatment. The most evident immunological effect associated with ALOE supplementation was the reduced prevalence of splenic NKT cells (p=0.02). In addition, the treatment appeared to increase the total proportion of CD4+ cells among splenic T cells (p=0.03) and the interferon-γ production by hepatic Th1 cells (p=0.06) tented to increase. In DMN-treated rats, the ALOE supplementation reduced the hepatic hydroxyproline content and α-SMA expression and improved the histopathology compared to controls. These results indicate that ALOE administration may have immunomodulatory effects and lower the fibrogenic process in the liver.en_US
dc.languageengen_US
dc.relation.ispartofEuropean Journal of Oncologyen_US
dc.subjectAloe Arborescensen_US
dc.subjectAnti-Inflammatory Effectsen_US
dc.subjectAntidiabetic Effectsen_US
dc.subjectAntitumorigenic Effectsen_US
dc.subjectLiveren_US
dc.titleAloe arborescens preparation and liver healthen_US
dc.typeArticleen_US
dc.identifier.emailElNezami, H: elnezami@hkucc.hku.hken_US
dc.identifier.authorityElNezami, H=rp00694en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-70449674709en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70449674709&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume14en_US
dc.identifier.issue2en_US
dc.identifier.spage93en_US
dc.identifier.epage101en_US
dc.publisher.placeItalyen_US
dc.identifier.scopusauthoridAnwar, WA=7004253805en_US
dc.identifier.scopusauthoridKirjavainen, PV=6701800774en_US
dc.identifier.scopusauthoridIsola, J=35248209900en_US
dc.identifier.scopusauthoridEl Zarka, M=35174146600en_US
dc.identifier.scopusauthoridSpiros, TM=35175119900en_US
dc.identifier.scopusauthoridElNezami, H=6603690577en_US

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