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Article: Cytokines and junction restructuring events during spermatogenesis in the testis: An emerging concept of regulation

TitleCytokines and junction restructuring events during spermatogenesis in the testis: An emerging concept of regulation
Authors
Issue Date2009
PublisherElsevier Ltd. The Journal's web site is located at BIOLOGY - BIOCHEMISTRY
Citation
Cytokine And Growth Factor Reviews, 2009, v. 20 n. 4, p. 329-338 How to Cite?
AbstractDuring spermatogenesis in mammalian testes, junction restructuring takes place at the Sertoli-Sertoli and Sertoli-germ cell interface, which is coupled with germ cell development, such as cell cycle progression, and translocation of the germ cell within the seminiferous epithelium. In the rat testis, restructuring of the blood-testis barrier (BTB) formed between Sertoli cells near the basement membrane and disruption of the apical ectoplasmic specialization (apical ES) between Sertoli cells and fully developed spermatids (spermatozoa) at the luminal edge of the seminiferous epithelium occur concurrently at stage VIII of the seminiferous epithelial cycle of spermatogenesis. These two processes are essential for the translocation of primary spermatocytes from the basal to the apical compartment to prepare for meiosis, and the release of spermatozoa into the lumen of the seminiferous epithelium at spermiation, respectively. Cytokines, such as TNFα and TGFβ3, are present at high levels in the microenvironment of the epithelium at this stage of the epithelial cycle. Since these cytokines were shown to disrupt the BTB integrity and germ cell adhesion, it was proposed that some cytokines released from germ cells, particularly primary spermatocytes, and Sertoli cells, would induce restructuring of the BTB and apical ES at stage VIII of the seminiferous epithelial cycle. In this review, the intricate role of cytokines and testosterone to regulate the transit of primary spermatocytes at the BTB and spermiation will be discussed. Possible regulators that mediate cytokine-induced junction restructuring, including gap junction and extracellular matrix, and the role of testosterone on junction dynamics in the testis will also be discussed. © 2009 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/179154
ISSN
2015 Impact Factor: 6.571
2015 SCImago Journal Rankings: 3.018
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, MWMen_US
dc.contributor.authorMruk, DDen_US
dc.contributor.authorLee, WMen_US
dc.contributor.authorCheng, CYen_US
dc.date.accessioned2012-12-19T09:52:24Z-
dc.date.available2012-12-19T09:52:24Z-
dc.date.issued2009en_US
dc.identifier.citationCytokine And Growth Factor Reviews, 2009, v. 20 n. 4, p. 329-338en_US
dc.identifier.issn1359-6101en_US
dc.identifier.urihttp://hdl.handle.net/10722/179154-
dc.description.abstractDuring spermatogenesis in mammalian testes, junction restructuring takes place at the Sertoli-Sertoli and Sertoli-germ cell interface, which is coupled with germ cell development, such as cell cycle progression, and translocation of the germ cell within the seminiferous epithelium. In the rat testis, restructuring of the blood-testis barrier (BTB) formed between Sertoli cells near the basement membrane and disruption of the apical ectoplasmic specialization (apical ES) between Sertoli cells and fully developed spermatids (spermatozoa) at the luminal edge of the seminiferous epithelium occur concurrently at stage VIII of the seminiferous epithelial cycle of spermatogenesis. These two processes are essential for the translocation of primary spermatocytes from the basal to the apical compartment to prepare for meiosis, and the release of spermatozoa into the lumen of the seminiferous epithelium at spermiation, respectively. Cytokines, such as TNFα and TGFβ3, are present at high levels in the microenvironment of the epithelium at this stage of the epithelial cycle. Since these cytokines were shown to disrupt the BTB integrity and germ cell adhesion, it was proposed that some cytokines released from germ cells, particularly primary spermatocytes, and Sertoli cells, would induce restructuring of the BTB and apical ES at stage VIII of the seminiferous epithelial cycle. In this review, the intricate role of cytokines and testosterone to regulate the transit of primary spermatocytes at the BTB and spermiation will be discussed. Possible regulators that mediate cytokine-induced junction restructuring, including gap junction and extracellular matrix, and the role of testosterone on junction dynamics in the testis will also be discussed. © 2009 Elsevier Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ltd. The Journal's web site is located at BIOLOGY - BIOCHEMISTRYen_US
dc.relation.ispartofCytokine and Growth Factor Reviewsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshHumansen_US
dc.subject.meshIntercellular Junctions - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshModels, Biologicalen_US
dc.subject.meshRatsen_US
dc.subject.meshSpermatogenesisen_US
dc.subject.meshTestis - Cytology - Metabolismen_US
dc.subject.meshTransforming Growth Factor Beta3 - Metabolismen_US
dc.subject.meshTumor Necrosis Factor-Alpha - Metabolismen_US
dc.titleCytokines and junction restructuring events during spermatogenesis in the testis: An emerging concept of regulationen_US
dc.typeArticleen_US
dc.identifier.emailLee, WM: hrszlwm@hku.hken_US
dc.identifier.authorityLee, WM=rp00728en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1016/j.cytogfr.2009.07.007en_US
dc.identifier.pmid19651533-
dc.identifier.pmcidPMC2758296-
dc.identifier.scopuseid_2-s2.0-69249213869en_US
dc.identifier.hkuros164880-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-69249213869&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume20en_US
dc.identifier.issue4en_US
dc.identifier.spage329en_US
dc.identifier.epage338en_US
dc.identifier.isiWOS:000270256100007-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLi, MWM=27168276300en_US
dc.identifier.scopusauthoridMruk, DD=6701823934en_US
dc.identifier.scopusauthoridLee, WM=24799156600en_US
dc.identifier.scopusauthoridCheng, CY=7404797787en_US
dc.identifier.citeulike5396809-

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