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Article: The influence of Lactobacillus rhamnosus LC705 together with Propionibacterium freudenreichii ssp. shermanii JS on potentially carcinogenic bacterial activity in human colon

TitleThe influence of Lactobacillus rhamnosus LC705 together with Propionibacterium freudenreichii ssp. shermanii JS on potentially carcinogenic bacterial activity in human colon
Authors
Issue Date2008
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ijfoodmicro
Citation
International Journal Of Food Microbiology, 2008, v. 128 n. 2, p. 406-410 How to Cite?
AbstractThe bacterial enzymes β-glucosidase, β-glucuronidase, and urease may contribute to the development of colon cancer by generating carcinogens. A reduction in the activity of these enzymes by certain lactic acid bacteria is considered to be beneficial. This study examined fecal β-glucosidase, β-glucuronidase, and urease activities during administration of Lactobacillus rhamnosus LC705 (LC705) together with Propionibacterium freudenreichii ssp shermanii JS (PJS). Thirty-eight healthy men participated in this randomized, double-blind, placebo-controlled, two-period crossover study with treatment periods of 4 weeks. Subjects consumed daily bacterial or placebo capsules. Bacterial capsules contained viable LC705 and PJS (2 × 1010 CFU of each strain daily). The activities of β-glucosidase, β-glucuronidase and urease, recovery of LC705 and PJS, and counts of total lactobacilli and propionibacteria were determined from feces. The mean fecal counts of total lactobacilli and propionibacteria as well as strains LC705 and PJS were significantly increased during the administration of bacteria (3.5-, 13-, 80- and 11-fold, respectively). β-glucosidase activity decreased by 10% (P = 0.18) and urease activity by 13% (P = 0.16) during bacterial supplementation versus placebo. The change in β-glucosidase activity was negatively correlated with the change in propionibacteria counts (R = - 0.350, P = 0.039), being - 2.68 versus 0.94 nmol/min/mg protein in subjects with increased and unchanged/decreased propionibacteria, respectively (P = 0.003). To conclude, the administration of LC705 and PJS was followed by an increase in the fecal counts of lactobacilli and propionibacteria and a decrease in the activity of β-glucosidase with increasing counts of propionibacteria. © 2008 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/179098
ISSN
2015 Impact Factor: 3.445
2015 SCImago Journal Rankings: 1.640
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHatakka, Ken_US
dc.contributor.authorHolma, Ren_US
dc.contributor.authorElNezami, Hen_US
dc.contributor.authorSuomalainen, Ten_US
dc.contributor.authorKuisma, Men_US
dc.contributor.authorSaxelin, Men_US
dc.contributor.authorPoussa, Ten_US
dc.contributor.authorMykkänen, Hen_US
dc.contributor.authorKorpela, Ren_US
dc.date.accessioned2012-12-19T09:51:58Z-
dc.date.available2012-12-19T09:51:58Z-
dc.date.issued2008en_US
dc.identifier.citationInternational Journal Of Food Microbiology, 2008, v. 128 n. 2, p. 406-410en_US
dc.identifier.issn0168-1605en_US
dc.identifier.urihttp://hdl.handle.net/10722/179098-
dc.description.abstractThe bacterial enzymes β-glucosidase, β-glucuronidase, and urease may contribute to the development of colon cancer by generating carcinogens. A reduction in the activity of these enzymes by certain lactic acid bacteria is considered to be beneficial. This study examined fecal β-glucosidase, β-glucuronidase, and urease activities during administration of Lactobacillus rhamnosus LC705 (LC705) together with Propionibacterium freudenreichii ssp shermanii JS (PJS). Thirty-eight healthy men participated in this randomized, double-blind, placebo-controlled, two-period crossover study with treatment periods of 4 weeks. Subjects consumed daily bacterial or placebo capsules. Bacterial capsules contained viable LC705 and PJS (2 × 1010 CFU of each strain daily). The activities of β-glucosidase, β-glucuronidase and urease, recovery of LC705 and PJS, and counts of total lactobacilli and propionibacteria were determined from feces. The mean fecal counts of total lactobacilli and propionibacteria as well as strains LC705 and PJS were significantly increased during the administration of bacteria (3.5-, 13-, 80- and 11-fold, respectively). β-glucosidase activity decreased by 10% (P = 0.18) and urease activity by 13% (P = 0.16) during bacterial supplementation versus placebo. The change in β-glucosidase activity was negatively correlated with the change in propionibacteria counts (R = - 0.350, P = 0.039), being - 2.68 versus 0.94 nmol/min/mg protein in subjects with increased and unchanged/decreased propionibacteria, respectively (P = 0.003). To conclude, the administration of LC705 and PJS was followed by an increase in the fecal counts of lactobacilli and propionibacteria and a decrease in the activity of β-glucosidase with increasing counts of propionibacteria. © 2008 Elsevier B.V. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ijfoodmicroen_US
dc.relation.ispartofInternational Journal of Food Microbiologyen_US
dc.subject.meshAdulten_US
dc.subject.meshColon - Enzymology - Microbiologyen_US
dc.subject.meshColonic Neoplasms - Enzymology - Microbiology - Prevention & Controlen_US
dc.subject.meshColony Count, Microbialen_US
dc.subject.meshCross-Over Studiesen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshFeces - Enzymology - Microbiologyen_US
dc.subject.meshGlucuronidase - Antagonists & Inhibitors - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshLactobacillus Rhamnosus - Physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProbiotics - Administration & Dosageen_US
dc.subject.meshPropionibacterium - Physiologyen_US
dc.subject.meshUrease - Antagonists & Inhibitors - Metabolismen_US
dc.subject.meshYoung Adulten_US
dc.subject.meshBeta-Glucosidase - Antagonists & Inhibitors - Metabolismen_US
dc.titleThe influence of Lactobacillus rhamnosus LC705 together with Propionibacterium freudenreichii ssp. shermanii JS on potentially carcinogenic bacterial activity in human colonen_US
dc.typeArticleen_US
dc.identifier.emailElNezami, H: elnezami@hkucc.hku.hken_US
dc.identifier.authorityElNezami, H=rp00694en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ijfoodmicro.2008.09.010en_US
dc.identifier.pmid18945506-
dc.identifier.scopuseid_2-s2.0-55549109358en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-55549109358&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume128en_US
dc.identifier.issue2en_US
dc.identifier.spage406en_US
dc.identifier.epage410en_US
dc.identifier.isiWOS:000261668100032-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridHatakka, K=16309563100en_US
dc.identifier.scopusauthoridHolma, R=6506929783en_US
dc.identifier.scopusauthoridElNezami, H=6603690577en_US
dc.identifier.scopusauthoridSuomalainen, T=6602154222en_US
dc.identifier.scopusauthoridKuisma, M=25230310500en_US
dc.identifier.scopusauthoridSaxelin, M=7004468452en_US
dc.identifier.scopusauthoridPoussa, T=6701796915en_US
dc.identifier.scopusauthoridMykkänen, H=7003915985en_US
dc.identifier.scopusauthoridKorpela, R=7005521118en_US

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