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Article: Antidiabetic activity of Mung bean extracts in diabetic KK-Ay mice

TitleAntidiabetic activity of Mung bean extracts in diabetic KK-Ay mice
Authors
Issue Date2008
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/jafcau
Citation
Journal Of Agricultural And Food Chemistry, 2008, v. 56 n. 19, p. 8869-8873 How to Cite?
AbstractThe antidiabetic effects of Mung bean sprout (MBS) extracts and Mung bean seed coat (MBSC) extracts were investigated in type 2 diabetic mice. Male KK-Ay mice and C57BL/6 mice were used in this study. In KK-A y mice, the blood glucose, plasma C-peptide, glucagon, total cholesterol, triglyceride, and blood urea nitrogen (BUN) levels were significantly higher than those in the C57BL/6 mice (P < 0.001, P < 0.001, P < 0.01, P < 0.001, P < 0.01, and P < 0.01). In addition, KK-Ay mice showed an obvious decrease in insulin immunoreactivity in pancreas as well. MBS and MBSC were orally administrated to KK-Ay mice for 5 weeks. It was found that MBS (2 g/kg) and MBSC (3 g/kg) lowered blood glucose, plasma C-peptide, glucagon, total cholesterol, triglyceride, and BUN levels and at the same time markedly improved glucose tolerance and increased insulin immunoreactive levels. These results suggest that MBS and MBSC exert an antidiabetic effect in type 2 diabetic mice. © 2008 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/179092
ISSN
2015 Impact Factor: 2.857
2015 SCImago Journal Rankings: 1.246
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYao, Yen_US
dc.contributor.authorChen, Fen_US
dc.contributor.authorWang, Men_US
dc.contributor.authorWang, Jen_US
dc.contributor.authorRen, Gen_US
dc.date.accessioned2012-12-19T09:51:54Z-
dc.date.available2012-12-19T09:51:54Z-
dc.date.issued2008en_US
dc.identifier.citationJournal Of Agricultural And Food Chemistry, 2008, v. 56 n. 19, p. 8869-8873en_US
dc.identifier.issn0021-8561en_US
dc.identifier.urihttp://hdl.handle.net/10722/179092-
dc.description.abstractThe antidiabetic effects of Mung bean sprout (MBS) extracts and Mung bean seed coat (MBSC) extracts were investigated in type 2 diabetic mice. Male KK-Ay mice and C57BL/6 mice were used in this study. In KK-A y mice, the blood glucose, plasma C-peptide, glucagon, total cholesterol, triglyceride, and blood urea nitrogen (BUN) levels were significantly higher than those in the C57BL/6 mice (P < 0.001, P < 0.001, P < 0.01, P < 0.001, P < 0.01, and P < 0.01). In addition, KK-Ay mice showed an obvious decrease in insulin immunoreactivity in pancreas as well. MBS and MBSC were orally administrated to KK-Ay mice for 5 weeks. It was found that MBS (2 g/kg) and MBSC (3 g/kg) lowered blood glucose, plasma C-peptide, glucagon, total cholesterol, triglyceride, and BUN levels and at the same time markedly improved glucose tolerance and increased insulin immunoreactive levels. These results suggest that MBS and MBSC exert an antidiabetic effect in type 2 diabetic mice. © 2008 American Chemical Society.en_US
dc.languageengen_US
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/jafcauen_US
dc.relation.ispartofJournal of Agricultural and Food Chemistryen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Glucose - Analysisen_US
dc.subject.meshDiabetes Mellitus - Blood - Drug Therapyen_US
dc.subject.meshFabaceae - Chemistryen_US
dc.subject.meshGlucose Tolerance Testen_US
dc.subject.meshHypoglycemic Agents - Analysisen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshInsulin - Analysisen_US
dc.subject.meshIslets Of Langerhans - Chemistryen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred C57blen_US
dc.subject.meshPhytotherapyen_US
dc.subject.meshPlant Extracts - Therapeutic Useen_US
dc.subject.meshSeeds - Chemistryen_US
dc.titleAntidiabetic activity of Mung bean extracts in diabetic KK-Ay miceen_US
dc.typeArticleen_US
dc.identifier.emailChen, F: sfchen@hku.hken_US
dc.identifier.emailWang, M: mfwang@hku.hken_US
dc.identifier.authorityChen, F=rp00672en_US
dc.identifier.authorityWang, M=rp00800en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1021/jf8009238en_US
dc.identifier.pmid18767859-
dc.identifier.scopuseid_2-s2.0-54349102371en_US
dc.identifier.hkuros163906-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-54349102371&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume56en_US
dc.identifier.issue19en_US
dc.identifier.spage8869en_US
dc.identifier.epage8873en_US
dc.identifier.isiWOS:000259675300014-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridYao, Y=35308337100en_US
dc.identifier.scopusauthoridChen, F=7404907980en_US
dc.identifier.scopusauthoridWang, M=7406691844en_US
dc.identifier.scopusauthoridWang, J=37069949900en_US
dc.identifier.scopusauthoridRen, G=7103325357en_US

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