File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Transcriptional and post-transcriptional regulations of junctions proteins in mammalian testes - Implications on male contraceptive development

TitleTranscriptional and post-transcriptional regulations of junctions proteins in mammalian testes - Implications on male contraceptive development
Authors
KeywordsCell Junction
Rhrna Degradation
Spermatogenesis
Transcription
Issue Date2008
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cmciema/index.htm
Citation
Immunology, Endocrine And Metabolic Agents In Medicinal Chemistry, 2008, v. 8 n. 1, p. 95-102 How to Cite?
AbstractIn adult mammalian testes, cell junctions not only maintain the integrity of the testis, their dynamic turnover also plays different crucial roles in spermatogenesis during the seminiferous epithelial cycle, such as cell-cell communication to coordinate meiosis, spermatid orientation and germ cell movement. In the testis, disassembly and reassembly of cell junctions at the Sertoli-Sertoli and Sertoli-germ cell interface allow the translocation of germ cells towards the adluminal compartment, but at the same time, germ cells remain attach to Sertoli cells for structural and nutritional supports. Temporal and spatial expressions of junction proteins in Sertoli cells and germ cells therefore become one of the major events to maintain such process. A precise control of such event could be in part achieved by transcriptional and post-transcriptional modifications of target genes pertinent to the components of the junction complexes. In this review, we aim to summarize the recent findings in the study of transcriptional and post-transcriptional regulations of junction proteins in epithelial cells and in the testis. It also highlights specific areas for future studies. A comprehensive study on this topic definitely leads to a thorough understanding of spermatogenesis and the development of new approaches for male contraception. © 2008 Bentham Science Publishers Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/179054
ISSN
2015 SCImago Journal Rankings: 0.135
References

 

DC FieldValueLanguage
dc.contributor.authorSze, KLen_US
dc.contributor.authorLui, WYen_US
dc.date.accessioned2012-12-19T09:51:40Z-
dc.date.available2012-12-19T09:51:40Z-
dc.date.issued2008en_US
dc.identifier.citationImmunology, Endocrine And Metabolic Agents In Medicinal Chemistry, 2008, v. 8 n. 1, p. 95-102en_US
dc.identifier.issn1871-5222en_US
dc.identifier.urihttp://hdl.handle.net/10722/179054-
dc.description.abstractIn adult mammalian testes, cell junctions not only maintain the integrity of the testis, their dynamic turnover also plays different crucial roles in spermatogenesis during the seminiferous epithelial cycle, such as cell-cell communication to coordinate meiosis, spermatid orientation and germ cell movement. In the testis, disassembly and reassembly of cell junctions at the Sertoli-Sertoli and Sertoli-germ cell interface allow the translocation of germ cells towards the adluminal compartment, but at the same time, germ cells remain attach to Sertoli cells for structural and nutritional supports. Temporal and spatial expressions of junction proteins in Sertoli cells and germ cells therefore become one of the major events to maintain such process. A precise control of such event could be in part achieved by transcriptional and post-transcriptional modifications of target genes pertinent to the components of the junction complexes. In this review, we aim to summarize the recent findings in the study of transcriptional and post-transcriptional regulations of junction proteins in epithelial cells and in the testis. It also highlights specific areas for future studies. A comprehensive study on this topic definitely leads to a thorough understanding of spermatogenesis and the development of new approaches for male contraception. © 2008 Bentham Science Publishers Ltd.en_US
dc.languageengen_US
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cmciema/index.htmen_US
dc.relation.ispartofImmunology, Endocrine and Metabolic Agents in Medicinal Chemistryen_US
dc.subjectCell Junctionen_US
dc.subjectRhrna Degradationen_US
dc.subjectSpermatogenesisen_US
dc.subjectTranscriptionen_US
dc.titleTranscriptional and post-transcriptional regulations of junctions proteins in mammalian testes - Implications on male contraceptive developmenten_US
dc.typeArticleen_US
dc.identifier.emailLui, WY: wylui@hku.hken_US
dc.identifier.authorityLui, WY=rp00756en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.2174/187152208783790787en_US
dc.identifier.scopuseid_2-s2.0-44149123113en_US
dc.identifier.hkuros146535-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-44149123113&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume8en_US
dc.identifier.issue1en_US
dc.identifier.spage95en_US
dc.identifier.epage102en_US
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridSze, KL=12779346400en_US
dc.identifier.scopusauthoridLui, WY=35220192400en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats