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Article: The wages of CIN

TitleThe wages of CIN
Authors
Issue Date2008
PublisherRockefeller University Press. The Journal's web site is located at http://www.jcb.org
Citation
Journal Of Cell Biology, 2008, v. 180 n. 4, p. 661-663 How to Cite?
AbstractAneuploidy and chromosome instability (CIN) are hallmarks of the majority of solid tumors, but the relationship between them is not well understood. In this issue, Thompson and Compton (Thompson, S.L., and D.A. Compton. 2008. Examining the link between chromosomal instability and aneuploidy in human cells. J. Cell. Biol. 180: 665-672) investigate the mechanism of CIN in cancer cells and find that CIN arises primarily from defective kinetochore-spindle attachments that evade detection by the spindle checkpoint and persist into anaphase. They also explore the consequences of artificially elevating chromosome missegregation in otherwise karyotypically normal cells. Their finding that induced aneuploidy is rapidly selected against suggests that the persistence of aneuploid cells in tumors requires not only chromosome missegregation but also additional, as yet poorly defined events. © The Rockefeller University Press.
Persistent Identifierhttp://hdl.handle.net/10722/179045
ISSN
2015 Impact Factor: 8.717
2015 SCImago Journal Rankings: 7.923
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuen, KWen_US
dc.contributor.authorDesai, Aen_US
dc.date.accessioned2012-12-19T09:51:37Z-
dc.date.available2012-12-19T09:51:37Z-
dc.date.issued2008en_US
dc.identifier.citationJournal Of Cell Biology, 2008, v. 180 n. 4, p. 661-663en_US
dc.identifier.issn0021-9525en_US
dc.identifier.urihttp://hdl.handle.net/10722/179045-
dc.description.abstractAneuploidy and chromosome instability (CIN) are hallmarks of the majority of solid tumors, but the relationship between them is not well understood. In this issue, Thompson and Compton (Thompson, S.L., and D.A. Compton. 2008. Examining the link between chromosomal instability and aneuploidy in human cells. J. Cell. Biol. 180: 665-672) investigate the mechanism of CIN in cancer cells and find that CIN arises primarily from defective kinetochore-spindle attachments that evade detection by the spindle checkpoint and persist into anaphase. They also explore the consequences of artificially elevating chromosome missegregation in otherwise karyotypically normal cells. Their finding that induced aneuploidy is rapidly selected against suggests that the persistence of aneuploid cells in tumors requires not only chromosome missegregation but also additional, as yet poorly defined events. © The Rockefeller University Press.en_US
dc.languageengen_US
dc.publisherRockefeller University Press. The Journal's web site is located at http://www.jcb.orgen_US
dc.relation.ispartofJournal of Cell Biologyen_US
dc.subject.meshAnaphase - Geneticsen_US
dc.subject.meshAneuploidyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Transformation, Neoplastic - Geneticsen_US
dc.subject.meshChromosomal Instability - Geneticsen_US
dc.subject.meshChromosome Segregation - Geneticsen_US
dc.subject.meshGenes, Cdc - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshKinetochores - Metabolism - Ultrastructureen_US
dc.subject.meshMitotic Spindle Apparatus - Geneticsen_US
dc.subject.meshNeoplasms - Geneticsen_US
dc.titleThe wages of CINen_US
dc.typeArticleen_US
dc.identifier.emailYuen, KW: kwyyuen@hku.hken_US
dc.identifier.authorityYuen, KW=rp01512en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1083/jcb.200801030en_US
dc.identifier.pmid18283117-
dc.identifier.scopuseid_2-s2.0-40849126945en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-40849126945&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume180en_US
dc.identifier.issue4en_US
dc.identifier.spage661en_US
dc.identifier.epage663en_US
dc.identifier.isiWOS:000253494000014-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridYuen, KW=8841935800en_US
dc.identifier.scopusauthoridDesai, A=7201793131en_US
dc.identifier.citeulike4100541-

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