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Article: Effect of Menopause on Gene Expression Profiles of Circulating Monocytes: A Pilot in vivo Microarray Study

TitleEffect of Menopause on Gene Expression Profiles of Circulating Monocytes: A Pilot in vivo Microarray Study
Authors
Issue Date2007
Citation
Journal Of Genetics And Genomics, 2007, v. 34 n. 11, p. 974-983 How to Cite?
AbstractMenopause is one of the key physiological events in the female life and can increase the risk for a number of complex autoimmune, neurodegenerative, metabolic, and cardiovascular disorders. Circulating monocytes can differentiate into various cell types and play an important role in tissue morphogenesis and immune response. We studied gene expression profiles of peripheral blood monocytes in healthy pre- and postmenopausal women using Affymetrix Human U133A GeneChip array that contains probes for ∼14,500 genes. Comparative analyses between the samples showed that 20 genes were up- and 20 were down-regulated. Of these genes, 28 were classified into six major GO categories relevant to such biological processes as the cell proliferation, immune response, cellular metabolism, and the others. The remaining 12 genes have yet unidentified biological functions. Our results support the hypothesis that functional state of circulating monocytes is indeed affected by menopause, and resulting changes may be determined through the genomewide gene expression profiling. Several differentially expressed genes identified in this study may be candidates for further studies of menopause-associated systemic autoimmune, neurodegenerative, and cardiovascular disorders. Our study is only the first attempt in this direction, but it lays a basis for further research. © 2007 Institute of Genetics and Developmental Biology and the Genetics Society of China.
Persistent Identifierhttp://hdl.handle.net/10722/179023
ISSN
2015 Impact Factor: 3.981
2015 SCImago Journal Rankings: 1.766
References

 

DC FieldValueLanguage
dc.contributor.authorDvornyk, Ven_US
dc.contributor.authorLiu, Yen_US
dc.contributor.authorLu, Yen_US
dc.contributor.authorShen, Hen_US
dc.contributor.authorLappe, JMen_US
dc.contributor.authorRecker, RRen_US
dc.contributor.authorDeng, Hen_US
dc.contributor.authorLei, Sen_US
dc.date.accessioned2012-12-19T09:51:30Z-
dc.date.available2012-12-19T09:51:30Z-
dc.date.issued2007en_US
dc.identifier.citationJournal Of Genetics And Genomics, 2007, v. 34 n. 11, p. 974-983en_US
dc.identifier.issn1673-8527en_US
dc.identifier.urihttp://hdl.handle.net/10722/179023-
dc.description.abstractMenopause is one of the key physiological events in the female life and can increase the risk for a number of complex autoimmune, neurodegenerative, metabolic, and cardiovascular disorders. Circulating monocytes can differentiate into various cell types and play an important role in tissue morphogenesis and immune response. We studied gene expression profiles of peripheral blood monocytes in healthy pre- and postmenopausal women using Affymetrix Human U133A GeneChip array that contains probes for ∼14,500 genes. Comparative analyses between the samples showed that 20 genes were up- and 20 were down-regulated. Of these genes, 28 were classified into six major GO categories relevant to such biological processes as the cell proliferation, immune response, cellular metabolism, and the others. The remaining 12 genes have yet unidentified biological functions. Our results support the hypothesis that functional state of circulating monocytes is indeed affected by menopause, and resulting changes may be determined through the genomewide gene expression profiling. Several differentially expressed genes identified in this study may be candidates for further studies of menopause-associated systemic autoimmune, neurodegenerative, and cardiovascular disorders. Our study is only the first attempt in this direction, but it lays a basis for further research. © 2007 Institute of Genetics and Developmental Biology and the Genetics Society of China.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Genetics and Genomicsen_US
dc.subject.meshBlood Circulationen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Expression Profilingen_US
dc.subject.meshHumansen_US
dc.subject.meshMenopause - Blood - Physiologyen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMonocytes - Metabolismen_US
dc.subject.meshOligonucleotide Array Sequence Analysisen_US
dc.subject.meshPilot Projectsen_US
dc.subject.meshPostmenopause - Blooden_US
dc.subject.meshPremenopause - Blooden_US
dc.titleEffect of Menopause on Gene Expression Profiles of Circulating Monocytes: A Pilot in vivo Microarray Studyen_US
dc.typeArticleen_US
dc.identifier.emailDvornyk, V: dvornyk@hku.hken_US
dc.identifier.authorityDvornyk, V=rp00693en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S1673-8527(07)60110-6en_US
dc.identifier.pmid18037134-
dc.identifier.scopuseid_2-s2.0-36248961034en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-36248961034&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume34en_US
dc.identifier.issue11en_US
dc.identifier.spage974en_US
dc.identifier.epage983en_US
dc.identifier.scopusauthoridDvornyk, V=6701789786en_US
dc.identifier.scopusauthoridLiu, Y=7410227746en_US
dc.identifier.scopusauthoridLu, Y=26321148700en_US
dc.identifier.scopusauthoridShen, H=36126870600en_US
dc.identifier.scopusauthoridLappe, JM=7003431855en_US
dc.identifier.scopusauthoridRecker, RR=7007086875en_US
dc.identifier.scopusauthoridDeng, H=34568563000en_US
dc.identifier.scopusauthoridLei, S=7102453442en_US
dc.identifier.citeulike3243427-

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