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Article: Epistasis between loci on chromosomes 2 and 6 influences human height

TitleEpistasis between loci on chromosomes 2 and 6 influences human height
Authors
Issue Date2006
PublisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.org
Citation
Journal Of Clinical Endocrinology And Metabolism, 2006, v. 91 n. 10, p. 3821-3825 How to Cite?
AbstractContext: Human height is a typical and important complex trait, which is determined by both actions and interactions of multiple genes. Although an increasing number of genes or genomic regions have been discovered for their independent effects on height variation, no study has been performed to identify genes or loci that interact to control the trait. Objective: This study aimed to search for potential genomic regions that harbor interactive genes underlying human height. Methods: Here with a sample containing 3726 Caucasians, the largest one ever obtained from a single population of the same ethnicity among genetic linkage studies of human complex traits, we performed variance component linkage analyses of height based on a two-locus epistatic model. We examined pairwise genetic interaction among three regions, 9q22, 6p21, and 2q21, which achieved significant or suggestive linkage signals for height in our recent whole genome scan. Results: Significant genetic interaction between 6p21 and 2q21 was detected, with 2q21 achieving a maximum LOD score of 3.21 (P = 0.0035) under the epistatic model, compared with a maximum LOD score of 1.63 under a two-locus additive model. Interestingly, 6p21 contains a cluster of candidate genes for skeletal growth, suggesting a mechanism whereby 2q21 regulates height through 6p21. Conclusion: By providing the first evidence for genetic interaction underlying human height variation, this study further delineated the genetic architecture of human height and contributed to the genetic dissection of human complex traits in general. Copyright © 2006 by The Endocrine Society.
Persistent Identifierhttp://hdl.handle.net/10722/178960
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.940
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, YZen_US
dc.contributor.authorGuo, YFen_US
dc.contributor.authorXiao, Pen_US
dc.contributor.authorXiong, DHen_US
dc.contributor.authorZhao, LJen_US
dc.contributor.authorShen, Hen_US
dc.contributor.authorLiu, YJen_US
dc.contributor.authorDvornyk, Ven_US
dc.contributor.authorLong, JRen_US
dc.contributor.authorDeng, HYen_US
dc.contributor.authorLi, JLen_US
dc.contributor.authorDeng, HWen_US
dc.date.accessioned2012-12-19T09:51:04Z-
dc.date.available2012-12-19T09:51:04Z-
dc.date.issued2006en_US
dc.identifier.citationJournal Of Clinical Endocrinology And Metabolism, 2006, v. 91 n. 10, p. 3821-3825en_US
dc.identifier.issn0021-972Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/178960-
dc.description.abstractContext: Human height is a typical and important complex trait, which is determined by both actions and interactions of multiple genes. Although an increasing number of genes or genomic regions have been discovered for their independent effects on height variation, no study has been performed to identify genes or loci that interact to control the trait. Objective: This study aimed to search for potential genomic regions that harbor interactive genes underlying human height. Methods: Here with a sample containing 3726 Caucasians, the largest one ever obtained from a single population of the same ethnicity among genetic linkage studies of human complex traits, we performed variance component linkage analyses of height based on a two-locus epistatic model. We examined pairwise genetic interaction among three regions, 9q22, 6p21, and 2q21, which achieved significant or suggestive linkage signals for height in our recent whole genome scan. Results: Significant genetic interaction between 6p21 and 2q21 was detected, with 2q21 achieving a maximum LOD score of 3.21 (P = 0.0035) under the epistatic model, compared with a maximum LOD score of 1.63 under a two-locus additive model. Interestingly, 6p21 contains a cluster of candidate genes for skeletal growth, suggesting a mechanism whereby 2q21 regulates height through 6p21. Conclusion: By providing the first evidence for genetic interaction underlying human height variation, this study further delineated the genetic architecture of human height and contributed to the genetic dissection of human complex traits in general. Copyright © 2006 by The Endocrine Society.en_US
dc.languageengen_US
dc.publisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.orgen_US
dc.relation.ispartofJournal of Clinical Endocrinology and Metabolismen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBody Height - Geneticsen_US
dc.subject.meshChromosomes, Human, Pair 2en_US
dc.subject.meshChromosomes, Human, Pair 6en_US
dc.subject.meshEpistasis, Geneticen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLod Scoreen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.titleEpistasis between loci on chromosomes 2 and 6 influences human heighten_US
dc.typeArticleen_US
dc.identifier.emailDvornyk, V: dvornyk@hku.hken_US
dc.identifier.authorityDvornyk, V=rp00693en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1210/jc.2006-0348en_US
dc.identifier.pmid16849413-
dc.identifier.scopuseid_2-s2.0-33749567371en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33749567371&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume91en_US
dc.identifier.issue10en_US
dc.identifier.spage3821en_US
dc.identifier.epage3825en_US
dc.identifier.isiWOS:000241100900019-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLiu, YZ=7410227746en_US
dc.identifier.scopusauthoridGuo, YF=34569758200en_US
dc.identifier.scopusauthoridXiao, P=34573749200en_US
dc.identifier.scopusauthoridXiong, DH=7007033697en_US
dc.identifier.scopusauthoridZhao, LJ=7404455505en_US
dc.identifier.scopusauthoridShen, H=36126870600en_US
dc.identifier.scopusauthoridLiu, YJ=36065513000en_US
dc.identifier.scopusauthoridDvornyk, V=6701789786en_US
dc.identifier.scopusauthoridLong, JR=7403446542en_US
dc.identifier.scopusauthoridDeng, HY=7401775454en_US
dc.identifier.scopusauthoridLi, JL=7410075530en_US
dc.identifier.scopusauthoridDeng, HW=7401775190en_US

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