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Article: Feedback regulation of growth hormone synthesis and secretion in fish and the emerging concept of intrapituitary feedback loop

TitleFeedback regulation of growth hormone synthesis and secretion in fish and the emerging concept of intrapituitary feedback loop
Authors
Issue Date2006
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cbpa
Citation
Comparative Biochemistry And Physiology - A Molecular And Integrative Physiology, 2006, v. 144 n. 3, p. 284-305 How to Cite?
AbstractGrowth hormone (GH) is known to play a key role in the regulation of body growth and metabolism. Similar to mammals, GH secretion in fish is under the control of hypothalamic factors. Besides, signals generated within the pituitary and/or from peripheral tissues/organs can also exert a feedback control on GH release by effects acting on both the hypothalamus and/or anterior pituitary. Among these feedback signals, the functional role of IGF is well conserved from fish to mammals. In contrast, the effects of steroids and thyroid hormones are more variable and appear to be species-specific. Recently, a novel intrapituitary feedback loop regulating GH release and GH gene expression has been identified in fish. This feedback loop has three functional components: (i) LH induction of GH release from somatotrophs, (ii) amplification of GH secretion by GH autoregulation in somatotrophs, and (iii) GH feedback inhibition of LH release from neighboring gonadotrophs. In this article, the mechanisms for feedback control of GH synthesis and secretion are reviewed and functional implications of this local feedback loop are discussed. This intrapituitary feedback loop may represent a new facet of pituitary research with potential applications in aquaculture and clinical studies. © 2005 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/178944
ISSN
2015 Impact Factor: 2.039
2015 SCImago Journal Rankings: 0.939
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, AOLen_US
dc.contributor.authorZhou, Hen_US
dc.contributor.authorJiang, Yen_US
dc.contributor.authorKo, WKWen_US
dc.date.accessioned2012-12-19T09:50:55Z-
dc.date.available2012-12-19T09:50:55Z-
dc.date.issued2006en_US
dc.identifier.citationComparative Biochemistry And Physiology - A Molecular And Integrative Physiology, 2006, v. 144 n. 3, p. 284-305en_US
dc.identifier.issn1095-6433en_US
dc.identifier.urihttp://hdl.handle.net/10722/178944-
dc.description.abstractGrowth hormone (GH) is known to play a key role in the regulation of body growth and metabolism. Similar to mammals, GH secretion in fish is under the control of hypothalamic factors. Besides, signals generated within the pituitary and/or from peripheral tissues/organs can also exert a feedback control on GH release by effects acting on both the hypothalamus and/or anterior pituitary. Among these feedback signals, the functional role of IGF is well conserved from fish to mammals. In contrast, the effects of steroids and thyroid hormones are more variable and appear to be species-specific. Recently, a novel intrapituitary feedback loop regulating GH release and GH gene expression has been identified in fish. This feedback loop has three functional components: (i) LH induction of GH release from somatotrophs, (ii) amplification of GH secretion by GH autoregulation in somatotrophs, and (iii) GH feedback inhibition of LH release from neighboring gonadotrophs. In this article, the mechanisms for feedback control of GH synthesis and secretion are reviewed and functional implications of this local feedback loop are discussed. This intrapituitary feedback loop may represent a new facet of pituitary research with potential applications in aquaculture and clinical studies. © 2005 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cbpaen_US
dc.relation.ispartofComparative Biochemistry and Physiology - A Molecular and Integrative Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshFeedback, Physiologicalen_US
dc.subject.meshFishes - Metabolismen_US
dc.subject.meshGene Expression Regulationen_US
dc.subject.meshGonadotropins - Metabolismen_US
dc.subject.meshGrowth Hormone - Biosynthesis - Metabolismen_US
dc.subject.meshLuteinizing Hormone - Metabolismen_US
dc.subject.meshMammals - Metabolismen_US
dc.subject.meshPituitary Gland - Metabolismen_US
dc.titleFeedback regulation of growth hormone synthesis and secretion in fish and the emerging concept of intrapituitary feedback loopen_US
dc.typeArticleen_US
dc.identifier.emailWong, AOL: olwong@hkucc.hku.hken_US
dc.identifier.authorityWong, AOL=rp00806en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.cbpa.2005.11.021en_US
dc.identifier.pmid16406825-
dc.identifier.scopuseid_2-s2.0-33745456254en_US
dc.identifier.hkuros123601-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745456254&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume144en_US
dc.identifier.issue3en_US
dc.identifier.spage284en_US
dc.identifier.epage305en_US
dc.identifier.isiWOS:000238730400005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWong, AOL=7403147570en_US
dc.identifier.scopusauthoridZhou, H=7404742310en_US
dc.identifier.scopusauthoridJiang, Y=15061459000en_US
dc.identifier.scopusauthoridKo, WKW=7202286890en_US

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