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Article: Predictive factors for age at menopause in Caucasian females

TitlePredictive factors for age at menopause in Caucasian females
Authors
Issue Date2006
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/maturitas
Citation
Maturitas, 2006, v. 54 n. 1, p. 19-26 How to Cite?
AbstractObjective: Early onset of menopause results in the premature exposure to low estrogen levels and is associated with a number of postmenopausal health problems and higher risk of mortality. The aim of this study was to determine genetic and environmental factors associated with age at natural and surgical menopause. Methods: Multiple regression analysis using a sample of Caucasians composed of 154 females with surgical and 248 with natural menopause. Results: Breastfeeding is a significant predictor of earlier natural menopause (P < 0.05). Use of oral contraceptives and smoking were not significantly associated with age at menopause. Females who did not have history of pregnancies are at significantly higher risk (P < 0.001) of getting early surgical menopause than those who did. We also tested the association of seven single nucleotide polymorphisms (SNPs) of the estrogen receptor α (ER-α) gene with age at menopause. No association was observed with age at menopause but the PvuII p allele was overrepresented in women with surgical menopause and associated with menopause per se (P = 0.029; OR = 1.8, 95% CI = 1.1-3.0). Conclusions: Breastfeeding and alcohol consumption are significantly associated with earlier natural menopause. No significant effects of the ER-α genotypes were observed on the age of menopause. Given the important role of the ER-α in estrogen signaling, which directly influences the menopausal process, further studies are required to better define the relationship between this gene and age at menopause. © 2005 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/178934
ISSN
2015 Impact Factor: 3.12
2015 SCImago Journal Rankings: 1.107
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDvornyk, Ven_US
dc.contributor.authorLong, JRen_US
dc.contributor.authorLiu, PYen_US
dc.contributor.authorZhao, LJen_US
dc.contributor.authorShen, Hen_US
dc.contributor.authorRecker, RRen_US
dc.contributor.authorDeng, HWen_US
dc.date.accessioned2012-12-19T09:50:50Z-
dc.date.available2012-12-19T09:50:50Z-
dc.date.issued2006en_US
dc.identifier.citationMaturitas, 2006, v. 54 n. 1, p. 19-26en_US
dc.identifier.issn0378-5122en_US
dc.identifier.urihttp://hdl.handle.net/10722/178934-
dc.description.abstractObjective: Early onset of menopause results in the premature exposure to low estrogen levels and is associated with a number of postmenopausal health problems and higher risk of mortality. The aim of this study was to determine genetic and environmental factors associated with age at natural and surgical menopause. Methods: Multiple regression analysis using a sample of Caucasians composed of 154 females with surgical and 248 with natural menopause. Results: Breastfeeding is a significant predictor of earlier natural menopause (P < 0.05). Use of oral contraceptives and smoking were not significantly associated with age at menopause. Females who did not have history of pregnancies are at significantly higher risk (P < 0.001) of getting early surgical menopause than those who did. We also tested the association of seven single nucleotide polymorphisms (SNPs) of the estrogen receptor α (ER-α) gene with age at menopause. No association was observed with age at menopause but the PvuII p allele was overrepresented in women with surgical menopause and associated with menopause per se (P = 0.029; OR = 1.8, 95% CI = 1.1-3.0). Conclusions: Breastfeeding and alcohol consumption are significantly associated with earlier natural menopause. No significant effects of the ER-α genotypes were observed on the age of menopause. Given the important role of the ER-α in estrogen signaling, which directly influences the menopausal process, further studies are required to better define the relationship between this gene and age at menopause. © 2005 Elsevier Ireland Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/maturitasen_US
dc.relation.ispartofMaturitasen_US
dc.subject.meshAge Of Onseten_US
dc.subject.meshAlcohol Drinking - Epidemiologyen_US
dc.subject.meshBreast Feeding - Epidemiologyen_US
dc.subject.meshCausalityen_US
dc.subject.meshEstrogen Receptor Alpha - Geneticsen_US
dc.subject.meshEuropean Continental Ancestry Groupen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMenopauseen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshParityen_US
dc.subject.meshPolymorphism, Single Nucleotideen_US
dc.subject.meshPregnancyen_US
dc.subject.meshSmoking - Epidemiologyen_US
dc.subject.meshUnited States - Epidemiologyen_US
dc.titlePredictive factors for age at menopause in Caucasian femalesen_US
dc.typeArticleen_US
dc.identifier.emailDvornyk, V: dvornyk@hku.hken_US
dc.identifier.authorityDvornyk, V=rp00693en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.maturitas.2005.08.005en_US
dc.identifier.pmid16213680-
dc.identifier.scopuseid_2-s2.0-33645101993en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33645101993&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume54en_US
dc.identifier.issue1en_US
dc.identifier.spage19en_US
dc.identifier.epage26en_US
dc.identifier.isiWOS:000236838300003-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridDvornyk, V=6701789786en_US
dc.identifier.scopusauthoridLong, JR=7403446542en_US
dc.identifier.scopusauthoridLiu, PY=7404618030en_US
dc.identifier.scopusauthoridZhao, LJ=7404455505en_US
dc.identifier.scopusauthoridShen, H=36126870600en_US
dc.identifier.scopusauthoridRecker, RR=7007086875en_US
dc.identifier.scopusauthoridDeng, HW=34568563000en_US

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