File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Contribution of genotype and ethnicity to bone mineral density variation in Caucasians and Chinese: A test for five candidate genes for bone mass

TitleContribution of genotype and ethnicity to bone mineral density variation in Caucasians and Chinese: A test for five candidate genes for bone mass
Authors
Issue Date2005
PublisherChinese Medical Association. The Journal's web site is located at http://www.cmj.org/
Citation
Chinese Medical Journal, 2005, v. 118 n. 15, p. 1235-1244 How to Cite?
AbstractBackground: Ethnicity is shown to be one of important factors affecting bone mineral density (BMD). The present study was performed to compare the association of six markers for five candidate genes with BMD variation in two populations of different ethnicity, Caucasian and Chinese, and the contribution of genotype and ethnicity to this variation in the populations. Methods: The studied restriction fragment length polymorphisms were BsaH I of the calcium-sensing receptor gene, Sac I of the α2 HS-glycoprotein (AHSG) gene, Pvu II and Xba I of the oestrogen receptor α gene, Apa I of the vitamin D receptor (VDR) gene and BstB I of the parathyroid hormone gene. The association of these markers with BMD was analysed by one-way and two-way ANOVA with adjustment for covariates. Results: Two polymorphisms, AHSG-Sac I and VDR-Apa I, showed no association with BMD, while the others were associated with BMD variation at some skeletal sites in either males or females. The polymorphisms indicated clear distinctions between the associations depending on ethnicity, gender and skeletal site. Similar patterns were observed in their contribution to the total population BMD variation. Ethnicity appears to have a larger effect on the total population BMD variation in females than in males. It may account, on the average, for about 2% total population BMD variation at the spine of females and about 1% at the hip of males and females. Conclusion: The results of the present study suggest that significant interethnic differentiation at some loci may contribute to the significant interethnic difference in BMD. However, this contribution apparently is not large.
Persistent Identifierhttp://hdl.handle.net/10722/178898
ISSN
2015 Impact Factor: 0.957
2015 SCImago Journal Rankings: 0.428
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDvornyk, Ven_US
dc.contributor.authorLiu, PYen_US
dc.contributor.authorLong, JRen_US
dc.contributor.authorZhang, YYen_US
dc.contributor.authorLei, SFen_US
dc.contributor.authorRecker, RRen_US
dc.contributor.authorDeng, HWen_US
dc.date.accessioned2012-12-19T09:50:33Z-
dc.date.available2012-12-19T09:50:33Z-
dc.date.issued2005en_US
dc.identifier.citationChinese Medical Journal, 2005, v. 118 n. 15, p. 1235-1244en_US
dc.identifier.issn0366-6999en_US
dc.identifier.urihttp://hdl.handle.net/10722/178898-
dc.description.abstractBackground: Ethnicity is shown to be one of important factors affecting bone mineral density (BMD). The present study was performed to compare the association of six markers for five candidate genes with BMD variation in two populations of different ethnicity, Caucasian and Chinese, and the contribution of genotype and ethnicity to this variation in the populations. Methods: The studied restriction fragment length polymorphisms were BsaH I of the calcium-sensing receptor gene, Sac I of the α2 HS-glycoprotein (AHSG) gene, Pvu II and Xba I of the oestrogen receptor α gene, Apa I of the vitamin D receptor (VDR) gene and BstB I of the parathyroid hormone gene. The association of these markers with BMD was analysed by one-way and two-way ANOVA with adjustment for covariates. Results: Two polymorphisms, AHSG-Sac I and VDR-Apa I, showed no association with BMD, while the others were associated with BMD variation at some skeletal sites in either males or females. The polymorphisms indicated clear distinctions between the associations depending on ethnicity, gender and skeletal site. Similar patterns were observed in their contribution to the total population BMD variation. Ethnicity appears to have a larger effect on the total population BMD variation in females than in males. It may account, on the average, for about 2% total population BMD variation at the spine of females and about 1% at the hip of males and females. Conclusion: The results of the present study suggest that significant interethnic differentiation at some loci may contribute to the significant interethnic difference in BMD. However, this contribution apparently is not large.en_US
dc.languageengen_US
dc.publisherChinese Medical Association. The Journal's web site is located at http://www.cmj.org/en_US
dc.relation.ispartofChinese Medical Journalen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshBlood Proteins - Geneticsen_US
dc.subject.meshBone Density - Geneticsen_US
dc.subject.meshEstrogen Receptor Alpha - Geneticsen_US
dc.subject.meshEuropean Continental Ancestry Groupen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOsteoporosis - Ethnology - Geneticsen_US
dc.subject.meshParathyroid Hormone - Geneticsen_US
dc.subject.meshReceptors, Calcitriol - Geneticsen_US
dc.subject.meshReceptors, Calcium-Sensing - Geneticsen_US
dc.subject.meshAlpha-2-Hs-Glycoproteinen_US
dc.titleContribution of genotype and ethnicity to bone mineral density variation in Caucasians and Chinese: A test for five candidate genes for bone massen_US
dc.typeArticleen_US
dc.identifier.emailDvornyk, V: dvornyk@hku.hken_US
dc.identifier.authorityDvornyk, V=rp00693en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.pmid16117875-
dc.identifier.scopuseid_2-s2.0-23844549342en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-23844549342&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume118en_US
dc.identifier.issue15en_US
dc.identifier.spage1235en_US
dc.identifier.epage1244en_US
dc.identifier.isiWOS:000231302200001-
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridDvornyk, V=6701789786en_US
dc.identifier.scopusauthoridLiu, PY=7404618030en_US
dc.identifier.scopusauthoridLong, JR=7403446542en_US
dc.identifier.scopusauthoridZhang, YY=12781205700en_US
dc.identifier.scopusauthoridLei, SF=7102453442en_US
dc.identifier.scopusauthoridRecker, RR=7007086875en_US
dc.identifier.scopusauthoridDeng, HW=34568563000en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats