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Article: Fecal and urinary excretion of aflatoxin B 1 metabolites (AFQ 1, AFM 1 and AFB-N 7-guanine) in young Chinese males

TitleFecal and urinary excretion of aflatoxin B 1 metabolites (AFQ 1, AFM 1 and AFB-N 7-guanine) in young Chinese males
Authors
Issue Date2005
PublisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home
Citation
International Journal Of Cancer, 2005, v. 115 n. 6, p. 879-884 How to Cite?
AbstractOur study was designed to assess the fecal and urinary excretion of 3 aflatoxin B 1 (AFB 1) metabolites, aflatoxins M 1 (AFM 1) and Q 1 (AFQ 1) and aflatoxin B 1-N 7-guanine (AFB-N 7-guanine) that are produced by the predominant forms of cytochrome P450 enzymes responsible for the biotransformation of AFB 1. Fecal and urinary AFM 1, AFQ 1 and urinary AFB-N 7-guanine were assessed in 83 young Chinese males selected from a larger population (n = 300) based on detectable urinary AFM 1. The concentration of fecal AFQ 1 (median 137 ng/g fresh weight, IQR 9.1 to 450) was approximately 60 times higher than that of AFM 1 (2.3 ng/g, IQR 0.0 to 7.3). In urine, the median AFQ 1 was 10.4 ng/ml (IQR 3.4 to 23.3), and the median AFM 1 and AFB-N 7-guanine 0.04 ng/ml (IQR 0.01 to 0.33) and 0.38 ng/ml (IQR 0.0 to 2.15), respectively. A subgroup (n = 14) with hepatitis B virus (HBV) infection had significantly higher fecal concentrations of AFQ 1 (p = 0.043) and AFM 1 (p = 0.001) than those who were hepatitis B-virus antigen (HBsAg) negative, and the respective differences in urinary AFQ 1 and AFM 1 concentrations approached statistical significance (p = 0.054, p = 0.138). Our study demonstrates that AFQ 1 is excreted in urine and feces at higher levels than AFM 1, and feces are an important route of excretion of these AFB 1 metabolites. AFQ 1 should be further assessed for its predictive value as a marker for exposure and risk of dietary aflatoxins. © 2005 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/178889
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.657
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMykkänen, Hen_US
dc.contributor.authorZhu, Hen_US
dc.contributor.authorSalminen, Een_US
dc.contributor.authorJuvonen, ROen_US
dc.contributor.authorLing, Wen_US
dc.contributor.authorMa, Jen_US
dc.contributor.authorPolychronaki, Nen_US
dc.contributor.authorKemiläinen, Hen_US
dc.contributor.authorMykkänen, Oen_US
dc.contributor.authorSalminen, Sen_US
dc.contributor.authorElNezami, Hen_US
dc.date.accessioned2012-12-19T09:50:29Z-
dc.date.available2012-12-19T09:50:29Z-
dc.date.issued2005en_US
dc.identifier.citationInternational Journal Of Cancer, 2005, v. 115 n. 6, p. 879-884en_US
dc.identifier.issn0020-7136en_US
dc.identifier.urihttp://hdl.handle.net/10722/178889-
dc.description.abstractOur study was designed to assess the fecal and urinary excretion of 3 aflatoxin B 1 (AFB 1) metabolites, aflatoxins M 1 (AFM 1) and Q 1 (AFQ 1) and aflatoxin B 1-N 7-guanine (AFB-N 7-guanine) that are produced by the predominant forms of cytochrome P450 enzymes responsible for the biotransformation of AFB 1. Fecal and urinary AFM 1, AFQ 1 and urinary AFB-N 7-guanine were assessed in 83 young Chinese males selected from a larger population (n = 300) based on detectable urinary AFM 1. The concentration of fecal AFQ 1 (median 137 ng/g fresh weight, IQR 9.1 to 450) was approximately 60 times higher than that of AFM 1 (2.3 ng/g, IQR 0.0 to 7.3). In urine, the median AFQ 1 was 10.4 ng/ml (IQR 3.4 to 23.3), and the median AFM 1 and AFB-N 7-guanine 0.04 ng/ml (IQR 0.01 to 0.33) and 0.38 ng/ml (IQR 0.0 to 2.15), respectively. A subgroup (n = 14) with hepatitis B virus (HBV) infection had significantly higher fecal concentrations of AFQ 1 (p = 0.043) and AFM 1 (p = 0.001) than those who were hepatitis B-virus antigen (HBsAg) negative, and the respective differences in urinary AFQ 1 and AFM 1 concentrations approached statistical significance (p = 0.054, p = 0.138). Our study demonstrates that AFQ 1 is excreted in urine and feces at higher levels than AFM 1, and feces are an important route of excretion of these AFB 1 metabolites. AFQ 1 should be further assessed for its predictive value as a marker for exposure and risk of dietary aflatoxins. © 2005 Wiley-Liss, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/homeen_US
dc.relation.ispartofInternational Journal of Canceren_US
dc.subject.meshAflatoxin B1 - Analogs & Derivatives - Metabolism - Urineen_US
dc.subject.meshAflatoxin M1 - Urineen_US
dc.subject.meshAflatoxins - Urineen_US
dc.subject.meshChinaen_US
dc.subject.meshFeces - Chemistryen_US
dc.subject.meshGuanine - Analogs & Derivatives - Urineen_US
dc.subject.meshHepatitis B - Complications - Urineen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.titleFecal and urinary excretion of aflatoxin B 1 metabolites (AFQ 1, AFM 1 and AFB-N 7-guanine) in young Chinese malesen_US
dc.typeArticleen_US
dc.identifier.emailElNezami, H: elnezami@hkucc.hku.hken_US
dc.identifier.authorityElNezami, H=rp00694en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ijc.20951en_US
dc.identifier.pmid15723309-
dc.identifier.scopuseid_2-s2.0-20344404714en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-20344404714&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume115en_US
dc.identifier.issue6en_US
dc.identifier.spage879en_US
dc.identifier.epage884en_US
dc.identifier.isiWOS:000229689700004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMykkänen, H=7003915985en_US
dc.identifier.scopusauthoridZhu, H=9237388600en_US
dc.identifier.scopusauthoridSalminen, E=7006341181en_US
dc.identifier.scopusauthoridJuvonen, RO=7005331813en_US
dc.identifier.scopusauthoridLing, W=14054110400en_US
dc.identifier.scopusauthoridMa, J=36079484000en_US
dc.identifier.scopusauthoridPolychronaki, N=6505944468en_US
dc.identifier.scopusauthoridKemiläinen, H=8581939400en_US
dc.identifier.scopusauthoridMykkänen, O=17346640500en_US
dc.identifier.scopusauthoridSalminen, S=7102912002en_US
dc.identifier.scopusauthoridElNezami, H=6603690577en_US

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