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Article: Molecular evolution of ldpA, a gene mediating the circadian input signal in cyanobacteria

TitleMolecular evolution of ldpA, a gene mediating the circadian input signal in cyanobacteria
Authors
Issue Date2005
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00239
Citation
Journal Of Molecular Evolution, 2005, v. 60 n. 1, p. 105-112 How to Cite?
AbstractThe ldpA gene is an element of the cyanobacterial circadian system and mediates input to the clock. Using complete prokaryotic genomes from various public databases, I analyzed the structure and phylogeny of the ldpA genes. This gene belongs to the large superfamily of ferredoxins and has a HycB domain as a core element of its structure. In addition to this domain, ldpA has two conserved terminal domains that are specific to this gene and have no homologs in the databases. All three domains are under different selective constraints. The ldpA tree topology features two very distinct clades that are essentially the same as those in the previously reported trees of the sasA gene and the kaiBC operon, two other elements of the circadian system. The data on the ldpA polymorphism and evolutionary patterns give further support to the existence of two types of the system, kaiABC- and kaiBC-based, respectively. Each type has specific functional and selective constraints, which have likely been attained through highly concordant evolution of the system's components.
Persistent Identifierhttp://hdl.handle.net/10722/178862
ISSN
2015 Impact Factor: 1.847
2015 SCImago Journal Rankings: 0.952
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDvornyk, Ven_US
dc.date.accessioned2012-12-19T09:50:14Z-
dc.date.available2012-12-19T09:50:14Z-
dc.date.issued2005en_US
dc.identifier.citationJournal Of Molecular Evolution, 2005, v. 60 n. 1, p. 105-112en_US
dc.identifier.issn0022-2844en_US
dc.identifier.urihttp://hdl.handle.net/10722/178862-
dc.description.abstractThe ldpA gene is an element of the cyanobacterial circadian system and mediates input to the clock. Using complete prokaryotic genomes from various public databases, I analyzed the structure and phylogeny of the ldpA genes. This gene belongs to the large superfamily of ferredoxins and has a HycB domain as a core element of its structure. In addition to this domain, ldpA has two conserved terminal domains that are specific to this gene and have no homologs in the databases. All three domains are under different selective constraints. The ldpA tree topology features two very distinct clades that are essentially the same as those in the previously reported trees of the sasA gene and the kaiBC operon, two other elements of the circadian system. The data on the ldpA polymorphism and evolutionary patterns give further support to the existence of two types of the system, kaiABC- and kaiBC-based, respectively. Each type has specific functional and selective constraints, which have likely been attained through highly concordant evolution of the system's components.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00239en_US
dc.relation.ispartofJournal of Molecular Evolutionen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshBacterial Proteins - Genetics - Physiologyen_US
dc.subject.meshBinding Sites - Geneticsen_US
dc.subject.meshCircadian Rhythm - Physiologyen_US
dc.subject.meshCyanobacteria - Classification - Genetics - Physiologyen_US
dc.subject.meshEvolution, Molecularen_US
dc.subject.meshIron-Sulfur Proteins - Genetics - Physiologyen_US
dc.subject.meshModels, Geneticen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshSelection, Geneticen_US
dc.subject.meshSequence Alignmenten_US
dc.subject.meshSequence Homology, Amino Aciden_US
dc.subject.meshSignal Transductionen_US
dc.titleMolecular evolution of ldpA, a gene mediating the circadian input signal in cyanobacteriaen_US
dc.typeArticleen_US
dc.identifier.emailDvornyk, V: dvornyk@hku.hken_US
dc.identifier.authorityDvornyk, V=rp00693en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00239-004-0073-0en_US
dc.identifier.pmid15696373-
dc.identifier.scopuseid_2-s2.0-14644411735en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-14644411735&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume60en_US
dc.identifier.issue1en_US
dc.identifier.spage105en_US
dc.identifier.epage112en_US
dc.identifier.isiWOS:000226136900010-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridDvornyk, V=6701789786en_US

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