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Article: Potent interaction between thyrotropin releasing hormone (TRH) and human pancreatic growth hormone releasing factor (hpGRF) in stimulating chicken growth hormone (cGH) in vivo: Hypothalamic noradrenergic mediation in TRH stimulation of cGH release

TitlePotent interaction between thyrotropin releasing hormone (TRH) and human pancreatic growth hormone releasing factor (hpGRF) in stimulating chicken growth hormone (cGH) in vivo: Hypothalamic noradrenergic mediation in TRH stimulation of cGH release
Authors
Issue Date1985
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/domaniend
Citation
Domestic Animal Endocrinology, 1985, v. 2 n. 4, p. 183-190 How to Cite?
AbstractThe interaction of human pancreatic growth hormone releasing factor (hpGRF) and thyrotropin releasing hormone (TRH) on chicken growth hormone (cGH) release in vivo and possible noradrenergic involvement on TRH-induced stimulation of cGH in vivo were examined. Four-week old cockerels (∼1 kg) were injected intravenously with hpGRF (1.0 μg/bird), TRH (0.1 μg/bird), or hpGRF (1.0 μg/bird) in combination with TRH (0.1 μg/bird). Five min after the injection, blood samples were collected and serum concentrations of cGH were determined by a homologous RIA. The results showed that hpGRF and TRH were potent stimulators of cGH release, 5- and 6-fold over the control birds, respectively, and that hpGRF and TRH administered in combination produced a synergistic stimulation of cGH release (>20 fold). In separate experiments, pretreatment with alpha-methyl-para-tyrosine (250 mg/bird) for 2 hours resulted in complete suppression of the TRH stimulatory effect on cGH release but not the stimulatory effect of hpGRF. Pretreated with phenoxybenzamine hydrochloride (20 mg/bird) or diethyl-dithiocarbamate (500 mg/bird) also resulted in complete suppression of TRH-induced cGH release. These results indicate that hpGRF acts directly at the pituitary and TRH acts at the hypothalamus in addition to the pituitary in stimulating cGH release, possibly mediated through the noradrenergic neurons. HpGRF and TRH were potent releasers of cGH and their stimulation was potentiated when administered together. © 1985.
Persistent Identifierhttp://hdl.handle.net/10722/178846
ISSN
2015 Impact Factor: 1.613
2015 SCImago Journal Rankings: 0.751

 

DC FieldValueLanguage
dc.contributor.authorLeung, FCen_US
dc.contributor.authorTaylor, JEen_US
dc.contributor.authorBall, CAen_US
dc.date.accessioned2012-12-19T09:50:06Z-
dc.date.available2012-12-19T09:50:06Z-
dc.date.issued1985en_US
dc.identifier.citationDomestic Animal Endocrinology, 1985, v. 2 n. 4, p. 183-190en_US
dc.identifier.issn0739-7240en_US
dc.identifier.urihttp://hdl.handle.net/10722/178846-
dc.description.abstractThe interaction of human pancreatic growth hormone releasing factor (hpGRF) and thyrotropin releasing hormone (TRH) on chicken growth hormone (cGH) release in vivo and possible noradrenergic involvement on TRH-induced stimulation of cGH in vivo were examined. Four-week old cockerels (∼1 kg) were injected intravenously with hpGRF (1.0 μg/bird), TRH (0.1 μg/bird), or hpGRF (1.0 μg/bird) in combination with TRH (0.1 μg/bird). Five min after the injection, blood samples were collected and serum concentrations of cGH were determined by a homologous RIA. The results showed that hpGRF and TRH were potent stimulators of cGH release, 5- and 6-fold over the control birds, respectively, and that hpGRF and TRH administered in combination produced a synergistic stimulation of cGH release (>20 fold). In separate experiments, pretreatment with alpha-methyl-para-tyrosine (250 mg/bird) for 2 hours resulted in complete suppression of the TRH stimulatory effect on cGH release but not the stimulatory effect of hpGRF. Pretreated with phenoxybenzamine hydrochloride (20 mg/bird) or diethyl-dithiocarbamate (500 mg/bird) also resulted in complete suppression of TRH-induced cGH release. These results indicate that hpGRF acts directly at the pituitary and TRH acts at the hypothalamus in addition to the pituitary in stimulating cGH release, possibly mediated through the noradrenergic neurons. HpGRF and TRH were potent releasers of cGH and their stimulation was potentiated when administered together. © 1985.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/domanienden_US
dc.relation.ispartofDomestic Animal Endocrinologyen_US
dc.titlePotent interaction between thyrotropin releasing hormone (TRH) and human pancreatic growth hormone releasing factor (hpGRF) in stimulating chicken growth hormone (cGH) in vivo: Hypothalamic noradrenergic mediation in TRH stimulation of cGH releaseen_US
dc.typeArticleen_US
dc.identifier.emailLeung, FC: fcleung@hkucc.hku.hken_US
dc.identifier.authorityLeung, FC=rp00731en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-10544226578en_US
dc.identifier.volume2en_US
dc.identifier.issue4en_US
dc.identifier.spage183en_US
dc.identifier.epage190en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLeung, FC=7103078633en_US
dc.identifier.scopusauthoridTaylor, JE=7405405625en_US
dc.identifier.scopusauthoridBall, CA=7201923554en_US

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