File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: TGF-βs: Their role in testicular function and Sertoli cell tight junction dynamics

TitleTGF-βs: Their role in testicular function and Sertoli cell tight junction dynamics
Authors
KeywordsSertoli Cell
Testis
Tgf-Βs
Tight Junction Dynamics
Issue Date2003
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IJA
Citation
International Journal Of Andrology, 2003, v. 26 n. 3, p. 147-160 How to Cite?
AbstractTransforming growth factor-βs (TGF-βs) are known to regulate multiple physiological functions in the testis, which include spermatogenesis, Leydig cell steroidogenesis, extracellular matrix synthesis and testis development. More recent studies have shown that TGF-β3 also regulates Sertoli cell tight junction (TJ) dynamics in vitro via the p38 mitogen-activated protein (MAP) kinase pathway, suggesting that this cytokine plays a crucial role in regulating the opening and closing of the blood-testis barrier (BTB). This in turn regulates the passage of pre-leptotene and leptotene spermatocytes across the BTB at stages VIII-XI of the seminiferous epithelial cycle. This review summarizes recent advances of studies on TGF-βs in the testis, highlighting their regulatory role in TJ dynamics.
Persistent Identifierhttp://hdl.handle.net/10722/178803
ISSN
2014 Impact Factor: 3.695
2015 SCImago Journal Rankings: 1.161
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLui, WYen_US
dc.contributor.authorLee, WMen_US
dc.contributor.authorCheng, CYen_US
dc.date.accessioned2012-12-19T09:49:50Z-
dc.date.available2012-12-19T09:49:50Z-
dc.date.issued2003en_US
dc.identifier.citationInternational Journal Of Andrology, 2003, v. 26 n. 3, p. 147-160en_US
dc.identifier.issn0105-6263en_US
dc.identifier.urihttp://hdl.handle.net/10722/178803-
dc.description.abstractTransforming growth factor-βs (TGF-βs) are known to regulate multiple physiological functions in the testis, which include spermatogenesis, Leydig cell steroidogenesis, extracellular matrix synthesis and testis development. More recent studies have shown that TGF-β3 also regulates Sertoli cell tight junction (TJ) dynamics in vitro via the p38 mitogen-activated protein (MAP) kinase pathway, suggesting that this cytokine plays a crucial role in regulating the opening and closing of the blood-testis barrier (BTB). This in turn regulates the passage of pre-leptotene and leptotene spermatocytes across the BTB at stages VIII-XI of the seminiferous epithelial cycle. This review summarizes recent advances of studies on TGF-βs in the testis, highlighting their regulatory role in TJ dynamics.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IJAen_US
dc.relation.ispartofInternational Journal of Andrologyen_US
dc.rightsInternational Journal of Andrology. Copyright © Blackwell Publishing Ltd.-
dc.subjectSertoli Cellen_US
dc.subjectTestisen_US
dc.subjectTgf-Βsen_US
dc.subjectTight Junction Dynamicsen_US
dc.titleTGF-βs: Their role in testicular function and Sertoli cell tight junction dynamicsen_US
dc.typeArticleen_US
dc.identifier.emailLui, WY: wylui@hku.hken_US
dc.identifier.emailLee, WM: hrszlwm@hku.hken_US
dc.identifier.authorityLui, WY=rp00756en_US
dc.identifier.authorityLee, WM=rp00728en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1046/j.1365-2605.2003.00410.xen_US
dc.identifier.pmid12755993-
dc.identifier.scopuseid_2-s2.0-0038460134en_US
dc.identifier.hkuros81241-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0038460134&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume26en_US
dc.identifier.issue3en_US
dc.identifier.spage147en_US
dc.identifier.epage160en_US
dc.identifier.isiWOS:000183034700004-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLui, WY=35220192400en_US
dc.identifier.scopusauthoridLee, WM=24799156600en_US
dc.identifier.scopusauthoridCheng, CY=7404797787en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats