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- Publisher Website: 10.1046/j.1365-2605.2003.00410.x
- Scopus: eid_2-s2.0-0038460134
- PMID: 12755993
- WOS: WOS:000183034700004
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Article: TGF-βs: Their role in testicular function and Sertoli cell tight junction dynamics
Title | TGF-βs: Their role in testicular function and Sertoli cell tight junction dynamics |
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Authors | |
Keywords | Sertoli Cell Testis Tgf-Βs Tight Junction Dynamics |
Issue Date | 2003 |
Publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IJA |
Citation | International Journal Of Andrology, 2003, v. 26 n. 3, p. 147-160 How to Cite? |
Abstract | Transforming growth factor-βs (TGF-βs) are known to regulate multiple physiological functions in the testis, which include spermatogenesis, Leydig cell steroidogenesis, extracellular matrix synthesis and testis development. More recent studies have shown that TGF-β3 also regulates Sertoli cell tight junction (TJ) dynamics in vitro via the p38 mitogen-activated protein (MAP) kinase pathway, suggesting that this cytokine plays a crucial role in regulating the opening and closing of the blood-testis barrier (BTB). This in turn regulates the passage of pre-leptotene and leptotene spermatocytes across the BTB at stages VIII-XI of the seminiferous epithelial cycle. This review summarizes recent advances of studies on TGF-βs in the testis, highlighting their regulatory role in TJ dynamics. |
Persistent Identifier | http://hdl.handle.net/10722/178803 |
ISSN | 2014 Impact Factor: 3.695 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Lui, WY | en_US |
dc.contributor.author | Lee, WM | en_US |
dc.contributor.author | Cheng, CY | en_US |
dc.date.accessioned | 2012-12-19T09:49:50Z | - |
dc.date.available | 2012-12-19T09:49:50Z | - |
dc.date.issued | 2003 | en_US |
dc.identifier.citation | International Journal Of Andrology, 2003, v. 26 n. 3, p. 147-160 | en_US |
dc.identifier.issn | 0105-6263 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/178803 | - |
dc.description.abstract | Transforming growth factor-βs (TGF-βs) are known to regulate multiple physiological functions in the testis, which include spermatogenesis, Leydig cell steroidogenesis, extracellular matrix synthesis and testis development. More recent studies have shown that TGF-β3 also regulates Sertoli cell tight junction (TJ) dynamics in vitro via the p38 mitogen-activated protein (MAP) kinase pathway, suggesting that this cytokine plays a crucial role in regulating the opening and closing of the blood-testis barrier (BTB). This in turn regulates the passage of pre-leptotene and leptotene spermatocytes across the BTB at stages VIII-XI of the seminiferous epithelial cycle. This review summarizes recent advances of studies on TGF-βs in the testis, highlighting their regulatory role in TJ dynamics. | en_US |
dc.language | eng | en_US |
dc.publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IJA | en_US |
dc.relation.ispartof | International Journal of Andrology | en_US |
dc.rights | International Journal of Andrology. Copyright © Blackwell Publishing Ltd. | - |
dc.subject | Sertoli Cell | en_US |
dc.subject | Testis | en_US |
dc.subject | Tgf-Βs | en_US |
dc.subject | Tight Junction Dynamics | en_US |
dc.title | TGF-βs: Their role in testicular function and Sertoli cell tight junction dynamics | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lui, WY: wylui@hku.hk | en_US |
dc.identifier.email | Lee, WM: hrszlwm@hku.hk | en_US |
dc.identifier.authority | Lui, WY=rp00756 | en_US |
dc.identifier.authority | Lee, WM=rp00728 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1046/j.1365-2605.2003.00410.x | en_US |
dc.identifier.pmid | 12755993 | - |
dc.identifier.scopus | eid_2-s2.0-0038460134 | en_US |
dc.identifier.hkuros | 81241 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0038460134&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 26 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 147 | en_US |
dc.identifier.epage | 160 | en_US |
dc.identifier.isi | WOS:000183034700004 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Lui, WY=35220192400 | en_US |
dc.identifier.scopusauthorid | Lee, WM=24799156600 | en_US |
dc.identifier.scopusauthorid | Cheng, CY=7404797787 | en_US |
dc.identifier.issnl | 0105-6263 | - |