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Article: Inhibition of cell transformation by resveratrol and its derivatives: Differential effects and mechanisms involved

TitleInhibition of cell transformation by resveratrol and its derivatives: Differential effects and mechanisms involved
Authors
Issue Date2003
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/onc
Citation
Oncogene, 2003, v. 22 n. 14, p. 2143-2150 How to Cite?
AbstractResveratrol, a constituent of grapes and other foods, has been reported to be a potential cancer chemopreventive agent. Our previous study showed that the antitumor activity of resveratrol occurs through mitogen-activated protein kinases-mediated p53 activation and induction of apoptosis. To develop more effective agents with fewer side effects for the chemoprevention of cancer, we investigated the effect of resveratrol and its structurally related derivatives on epidermal growth factor (EGF)-induced cell transformation. Our results provided the first evidence that one of the resveratrol derivatives exerted a more potent inhibitory effect than resveratrol on EGF-induced cell transformation, but had less cytotoxic effects on normal nontransformed cells. Compared to resveratrol, this compound also caused cell cycle arrest in the G1 phase, but did not induce p53 activation and apoptosis. Furthermore, this compound, but not resveratrol, markedly inhibited EGF-induced phosphatidylinositol-3 kinase (PI-3K) and Akt activation. Collectively, these data suggested that the higher antitumor effect of the compound compared to resveratrol, may act through a different mechanism by mainly targeting PI-3K/Akt signaling pathways.
Persistent Identifierhttp://hdl.handle.net/10722/178801
ISSN
2015 Impact Factor: 7.932
2015 SCImago Journal Rankings: 4.047
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorShe, QBen_US
dc.contributor.authorMa, WYen_US
dc.contributor.authorWang, Men_US
dc.contributor.authorKaji, Aen_US
dc.contributor.authorHo, CTen_US
dc.contributor.authorDong, Zen_US
dc.date.accessioned2012-12-19T09:49:49Z-
dc.date.available2012-12-19T09:49:49Z-
dc.date.issued2003en_US
dc.identifier.citationOncogene, 2003, v. 22 n. 14, p. 2143-2150en_US
dc.identifier.issn0950-9232en_US
dc.identifier.urihttp://hdl.handle.net/10722/178801-
dc.description.abstractResveratrol, a constituent of grapes and other foods, has been reported to be a potential cancer chemopreventive agent. Our previous study showed that the antitumor activity of resveratrol occurs through mitogen-activated protein kinases-mediated p53 activation and induction of apoptosis. To develop more effective agents with fewer side effects for the chemoprevention of cancer, we investigated the effect of resveratrol and its structurally related derivatives on epidermal growth factor (EGF)-induced cell transformation. Our results provided the first evidence that one of the resveratrol derivatives exerted a more potent inhibitory effect than resveratrol on EGF-induced cell transformation, but had less cytotoxic effects on normal nontransformed cells. Compared to resveratrol, this compound also caused cell cycle arrest in the G1 phase, but did not induce p53 activation and apoptosis. Furthermore, this compound, but not resveratrol, markedly inhibited EGF-induced phosphatidylinositol-3 kinase (PI-3K) and Akt activation. Collectively, these data suggested that the higher antitumor effect of the compound compared to resveratrol, may act through a different mechanism by mainly targeting PI-3K/Akt signaling pathways.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/oncen_US
dc.relation.ispartofOncogeneen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnticarcinogenic Agents - Pharmacologyen_US
dc.subject.meshApoptosis - Drug Effectsen_US
dc.subject.meshCell Lineen_US
dc.subject.meshCell Transformation, Neoplastic - Chemically Induced - Drug Effectsen_US
dc.subject.meshEpidermal Growth Factoren_US
dc.subject.meshG1 Phase - Drug Effectsen_US
dc.subject.meshGene Expression Regulationen_US
dc.subject.meshGenes, P53en_US
dc.subject.meshMiceen_US
dc.subject.meshStilbenes - Chemical Synthesis - Pharmacologyen_US
dc.titleInhibition of cell transformation by resveratrol and its derivatives: Differential effects and mechanisms involveden_US
dc.typeArticleen_US
dc.identifier.emailWang, M: mfwang@hku.hken_US
dc.identifier.authorityWang, M=rp00800en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/sj.onc.1206370en_US
dc.identifier.pmid12687016-
dc.identifier.scopuseid_2-s2.0-0038297516en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0038297516&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume22en_US
dc.identifier.issue14en_US
dc.identifier.spage2143en_US
dc.identifier.epage2150en_US
dc.identifier.isiWOS:000182066900008-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridShe, QB=7004176131en_US
dc.identifier.scopusauthoridMa, WY=36071951400en_US
dc.identifier.scopusauthoridWang, M=7406691844en_US
dc.identifier.scopusauthoridKaji, A=36902726600en_US
dc.identifier.scopusauthoridHo, CT=7404652573en_US
dc.identifier.scopusauthoridDong, Z=7402274347en_US

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