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Article: The effect of orally administered viable probiotic and dairy lactobacilli on mouse lymphocyte proliferation

TitleThe effect of orally administered viable probiotic and dairy lactobacilli on mouse lymphocyte proliferation
Authors
Issue Date1999
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0928-8244&site=1
Citation
Fems Immunology And Medical Microbiology, 1999, v. 26 n. 2, p. 131-135 How to Cite?
AbstractFour common Lactobacillus strains were screened for their effects on proliferation of mouse splenic lymphocytes. Mice received perorally 109 viable bacteria kg-1 body weight for 7 days. Lactobacillus acidophilus treatment enhanced ex vivo basal proliferation (by 43%) and B-cell response at suboptimal and optimal concentrations of lipopolysaccharide (LPS) (by 27-28%). Conversely, Lactobacillus casei, Lactobacillus gasseri and Lactobacillus rhamnosus inhibited both basal proliferation (by 14-51%) and mitogen-stimulated lymphoproliferation, particularly at supra-optimal concentrations of concanavalin A (by 43-68%) and LPS (by 23-62%). Therefore, these Lactobacillus strains demonstrate strain-specific effects on B- and T-cells and may also alter the splenocyte sensitivity to the cytotoxic effects of mitogens. Copyright (C) 1999 Federation of European Microbiological Societies.
Persistent Identifierhttp://hdl.handle.net/10722/178655
ISSN
2014 Impact Factor: 3.078
References

 

DC FieldValueLanguage
dc.contributor.authorKirjavainen, PVen_US
dc.contributor.authorElNezami, HSen_US
dc.contributor.authorSalminen, SJen_US
dc.contributor.authorAhokas, JTen_US
dc.contributor.authorWright, PFAen_US
dc.date.accessioned2012-12-19T09:48:58Z-
dc.date.available2012-12-19T09:48:58Z-
dc.date.issued1999en_US
dc.identifier.citationFems Immunology And Medical Microbiology, 1999, v. 26 n. 2, p. 131-135en_US
dc.identifier.issn0928-8244en_US
dc.identifier.urihttp://hdl.handle.net/10722/178655-
dc.description.abstractFour common Lactobacillus strains were screened for their effects on proliferation of mouse splenic lymphocytes. Mice received perorally 109 viable bacteria kg-1 body weight for 7 days. Lactobacillus acidophilus treatment enhanced ex vivo basal proliferation (by 43%) and B-cell response at suboptimal and optimal concentrations of lipopolysaccharide (LPS) (by 27-28%). Conversely, Lactobacillus casei, Lactobacillus gasseri and Lactobacillus rhamnosus inhibited both basal proliferation (by 14-51%) and mitogen-stimulated lymphoproliferation, particularly at supra-optimal concentrations of concanavalin A (by 43-68%) and LPS (by 23-62%). Therefore, these Lactobacillus strains demonstrate strain-specific effects on B- and T-cells and may also alter the splenocyte sensitivity to the cytotoxic effects of mitogens. Copyright (C) 1999 Federation of European Microbiological Societies.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0928-8244&site=1en_US
dc.relation.ispartofFEMS Immunology and Medical Microbiologyen_US
dc.subject.meshAdjuvants, Immunologic - Administration & Dosage - Pharmacologyen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Divisionen_US
dc.subject.meshConcanavalin A - Pharmacologyen_US
dc.subject.meshLactobacillusen_US
dc.subject.meshLactobacillus Acidophilusen_US
dc.subject.meshLactobacillus Caseien_US
dc.subject.meshLipopolysaccharides - Pharmacologyen_US
dc.subject.meshLymphocytes - Cytologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMitogens - Pharmacologyen_US
dc.subject.meshProbiotics - Administration & Dosage - Pharmacologyen_US
dc.subject.meshSpecies Specificityen_US
dc.subject.meshSpleen - Cytologyen_US
dc.titleThe effect of orally administered viable probiotic and dairy lactobacilli on mouse lymphocyte proliferationen_US
dc.typeArticleen_US
dc.identifier.emailElNezami, HS: elnezami@hkucc.hku.hken_US
dc.identifier.authorityElNezami, HS=rp00694en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0928-8244(99)00130-3en_US
dc.identifier.pmid10536299-
dc.identifier.scopuseid_2-s2.0-0032853186en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032853186&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume26en_US
dc.identifier.issue2en_US
dc.identifier.spage131en_US
dc.identifier.epage135en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridKirjavainen, PV=6701800774en_US
dc.identifier.scopusauthoridElNezami, HS=6603690577en_US
dc.identifier.scopusauthoridSalminen, SJ=7102912002en_US
dc.identifier.scopusauthoridAhokas, JT=7006308329en_US
dc.identifier.scopusauthoridWright, PFA=7404315992en_US

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