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Article: Oxidative and malondialdehyde modification of low-density lipoprotein: A comparative study

TitleOxidative and malondialdehyde modification of low-density lipoprotein: A comparative study
Authors
Issue Date1997
PublisherStep Communications Ltd. The Journal's web site is located at http://www.ibms.org/index.cfm?method=publications.british_journal
Citation
British Journal Of Biomedical Science, 1997, v. 54 n. 3, p. 159-165 How to Cite?
AbstractLow-density lipoprotein (LDL) was modified with copper ions (Cu 2+) and malondialdehyde (MDA), and the differences were compared. The results show that both oxidative and MDA modification produce a decrease in free amino groups in LDL and enhance its electrophoretic mobility on agarose gel, and that these observations are linked. However, differences produced by the two forms of modification were observed. Oxidative modification of LDL involves free radical-mediated lipid peroxidation which produces large amounts of thiobarbituric acid-reactive substances (TBARS) and conjugated dienes. In addition, vitamin E was reduced considerably and cholesterol lowered, and apolipoprotein B (apo B) fragmentation and aggregation were seen. Similar changes were not seen with MDA modification which does not involve lipid peroxidation. Fluorescence emission spectra of both forms of modified LDL show that emission intensity increases gradually as the modification progresses, but maximum emission wavelength and spectrum patterns are not the same. These findings may be of some significance in the study of the antigenicity, scavenger receptor multiplicity and toxic effects of modified LDL.
Persistent Identifierhttp://hdl.handle.net/10722/178600
ISSN
2015 Impact Factor: 1.245
2015 SCImago Journal Rankings: 0.352
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, Yen_US
dc.contributor.authorZhou, Men_US
dc.contributor.authorLiu, Sen_US
dc.contributor.authorDing, Zen_US
dc.contributor.authorLou, Nen_US
dc.contributor.authorPang, Zen_US
dc.contributor.authorWan, Jen_US
dc.date.accessioned2012-12-19T09:48:36Z-
dc.date.available2012-12-19T09:48:36Z-
dc.date.issued1997en_US
dc.identifier.citationBritish Journal Of Biomedical Science, 1997, v. 54 n. 3, p. 159-165en_US
dc.identifier.issn0967-4845en_US
dc.identifier.urihttp://hdl.handle.net/10722/178600-
dc.description.abstractLow-density lipoprotein (LDL) was modified with copper ions (Cu 2+) and malondialdehyde (MDA), and the differences were compared. The results show that both oxidative and MDA modification produce a decrease in free amino groups in LDL and enhance its electrophoretic mobility on agarose gel, and that these observations are linked. However, differences produced by the two forms of modification were observed. Oxidative modification of LDL involves free radical-mediated lipid peroxidation which produces large amounts of thiobarbituric acid-reactive substances (TBARS) and conjugated dienes. In addition, vitamin E was reduced considerably and cholesterol lowered, and apolipoprotein B (apo B) fragmentation and aggregation were seen. Similar changes were not seen with MDA modification which does not involve lipid peroxidation. Fluorescence emission spectra of both forms of modified LDL show that emission intensity increases gradually as the modification progresses, but maximum emission wavelength and spectrum patterns are not the same. These findings may be of some significance in the study of the antigenicity, scavenger receptor multiplicity and toxic effects of modified LDL.en_US
dc.languageengen_US
dc.publisherStep Communications Ltd. The Journal's web site is located at http://www.ibms.org/index.cfm?method=publications.british_journalen_US
dc.relation.ispartofBritish Journal of Biomedical Scienceen_US
dc.subject.meshCopperen_US
dc.subject.meshHumansen_US
dc.subject.meshLipid Peroxidationen_US
dc.subject.meshLipoproteins, Ldl - Chemistryen_US
dc.subject.meshMalondialdehydeen_US
dc.subject.meshOxidation-Reductionen_US
dc.titleOxidative and malondialdehyde modification of low-density lipoprotein: A comparative studyen_US
dc.typeArticleen_US
dc.identifier.emailWan, J: jmfwan@hku.hken_US
dc.identifier.authorityWan, J=rp00798en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid9499592-
dc.identifier.scopuseid_2-s2.0-0030814561en_US
dc.identifier.hkuros35647-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030814561&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume54en_US
dc.identifier.issue3en_US
dc.identifier.spage159en_US
dc.identifier.epage165en_US
dc.identifier.isiWOS:A1997XX89400002-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridChen, Y=16745998900en_US
dc.identifier.scopusauthoridZhou, M=7403506134en_US
dc.identifier.scopusauthoridLiu, S=7409463469en_US
dc.identifier.scopusauthoridDing, Z=35247593000en_US
dc.identifier.scopusauthoridLou, N=7006629613en_US
dc.identifier.scopusauthoridPang, Z=7103343225en_US
dc.identifier.scopusauthoridWan, J=8930305000en_US

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