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Article: Injury to mitochondria of mouse peritoneal macrophages caused by oxidised low-density lipoprotein, and protection afforded by polysaccharide krestin

TitleInjury to mitochondria of mouse peritoneal macrophages caused by oxidised low-density lipoprotein, and protection afforded by polysaccharide krestin
Authors
KeywordsAcas570
Lipid Hydroperoxide
Low-Density Lipoprotein
Mitochondrial Membrane Potential
Peritoneal Macrophage
Polysaccharide Krestin (Psk)
Issue Date1996
PublisherChapman & Hall, Journals Department. The Journal's web site is located at http://www.chaphall.com/chaphall/journals.html
Citation
Medical Science Research, 1996, v. 24 n. 10, p. 715-717 How to Cite?
AbstractInjury to mitochondria of mouse peritoneal macrophages caused by oxidised low-density lipoprotein (Ox-LDL) and the protective effect of a protein-bound polysaccharide krestin (PSK) from Coriolus versicolor were observed by measuring mitochondrial membrane potential according to fluorescence intensity using an ACAS570. Ox-LDL incubated with macrophages caused a decrease in mitochondrial membrane potential- an indicator of cytotoxicity. As compared with Ox-LDL, native LDL had no effect and acetylated LDL(AC-LDL) had a lesser effect on mitochondrial membrane potential. PSK, a non-specific immune enhancer intraperitoneally injected into mice, protected mitochondria of macrophage from the injury caused by Ox-LDL. The mechanism of injury may be related to the accumulation of lipid hydroperoxides (LPO) in macrophages and PSK protected cells by decreasing cellular LPO.
Persistent Identifierhttp://hdl.handle.net/10722/178585
ISSN
2001 Impact Factor: 0.384
2003 SCImago Journal Rankings: 0.107
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, SXen_US
dc.contributor.authorZhou, Men_US
dc.contributor.authorChert, Yen_US
dc.contributor.authorWen, WYen_US
dc.contributor.authorWan, Jen_US
dc.date.accessioned2012-12-19T09:48:30Z-
dc.date.available2012-12-19T09:48:30Z-
dc.date.issued1996en_US
dc.identifier.citationMedical Science Research, 1996, v. 24 n. 10, p. 715-717en_US
dc.identifier.issn0269-8951en_US
dc.identifier.urihttp://hdl.handle.net/10722/178585-
dc.description.abstractInjury to mitochondria of mouse peritoneal macrophages caused by oxidised low-density lipoprotein (Ox-LDL) and the protective effect of a protein-bound polysaccharide krestin (PSK) from Coriolus versicolor were observed by measuring mitochondrial membrane potential according to fluorescence intensity using an ACAS570. Ox-LDL incubated with macrophages caused a decrease in mitochondrial membrane potential- an indicator of cytotoxicity. As compared with Ox-LDL, native LDL had no effect and acetylated LDL(AC-LDL) had a lesser effect on mitochondrial membrane potential. PSK, a non-specific immune enhancer intraperitoneally injected into mice, protected mitochondria of macrophage from the injury caused by Ox-LDL. The mechanism of injury may be related to the accumulation of lipid hydroperoxides (LPO) in macrophages and PSK protected cells by decreasing cellular LPO.en_US
dc.languageengen_US
dc.publisherChapman & Hall, Journals Department. The Journal's web site is located at http://www.chaphall.com/chaphall/journals.htmlen_US
dc.relation.ispartofMedical Science Researchen_US
dc.subjectAcas570en_US
dc.subjectLipid Hydroperoxideen_US
dc.subjectLow-Density Lipoproteinen_US
dc.subjectMitochondrial Membrane Potentialen_US
dc.subjectPeritoneal Macrophageen_US
dc.subjectPolysaccharide Krestin (Psk)en_US
dc.titleInjury to mitochondria of mouse peritoneal macrophages caused by oxidised low-density lipoprotein, and protection afforded by polysaccharide krestinen_US
dc.typeArticleen_US
dc.identifier.emailWan, J: jmfwan@hku.hken_US
dc.identifier.authorityWan, J=rp00798en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0029854740en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029854740&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume24en_US
dc.identifier.issue10en_US
dc.identifier.spage715en_US
dc.identifier.epage717en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLiu, SX=7409463469en_US
dc.identifier.scopusauthoridZhou, M=7403506134en_US
dc.identifier.scopusauthoridChert, Y=14918992500en_US
dc.identifier.scopusauthoridWen, WY=7102170594en_US
dc.identifier.scopusauthoridWan, J=8930305000en_US

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