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Article: Transgene-encoded antiphosphorylcholine (T15 +) antibodies protect CBA/N (xid) mice against infection with Streptococcus pneumoniae but not Trichinella spiralis

TitleTransgene-encoded antiphosphorylcholine (T15 +) antibodies protect CBA/N (xid) mice against infection with Streptococcus pneumoniae but not Trichinella spiralis
Authors
Issue Date1994
PublisherAmerican Society for Microbiology. The Journal's web site is located at http://iai.asm.org/
Citation
Infection And Immunity, 1994, v. 62 n. 5, p. 1658-1661 How to Cite?
AbstractImmunodeficient CBA/N (xid) mice are highly susceptible to Streptococcus pneumoniae infection. Previous studies indicated that this susceptibility may be attributed to the lack of antibodies to phosphorylcholine (PC) in the circulation of these animals. We now provide direct proof that when these mice are genetically manipulated to produce significant amounts of circulating anti-PC immunoglobulin G antibodies of the T15 idiotype, they can be protected against a lethal challenge with S. pneumoniae. Transgenic mice were also used to investigate whether the transgene-encoded antibodies could protect the animals against another PC-bearing microorganism, Trichinella spiralis; in this case, there was no protection. These results were further supported by experiments with CFW mice which had been immunized to produce high levels of anti-PC antibodies but which were found to be just as susceptible to T. spiralis infection as nonimmunized animals.
Persistent Identifierhttp://hdl.handle.net/10722/178568
ISSN
2015 Impact Factor: 3.603
2015 SCImago Journal Rankings: 2.342
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPak Leong Limen_US
dc.contributor.authorChoy, WFen_US
dc.contributor.authorChan, STHen_US
dc.contributor.authorLeung, DTMen_US
dc.contributor.authorNg, SSMen_US
dc.date.accessioned2012-12-19T09:48:26Z-
dc.date.available2012-12-19T09:48:26Z-
dc.date.issued1994en_US
dc.identifier.citationInfection And Immunity, 1994, v. 62 n. 5, p. 1658-1661en_US
dc.identifier.issn0019-9567en_US
dc.identifier.urihttp://hdl.handle.net/10722/178568-
dc.description.abstractImmunodeficient CBA/N (xid) mice are highly susceptible to Streptococcus pneumoniae infection. Previous studies indicated that this susceptibility may be attributed to the lack of antibodies to phosphorylcholine (PC) in the circulation of these animals. We now provide direct proof that when these mice are genetically manipulated to produce significant amounts of circulating anti-PC immunoglobulin G antibodies of the T15 idiotype, they can be protected against a lethal challenge with S. pneumoniae. Transgenic mice were also used to investigate whether the transgene-encoded antibodies could protect the animals against another PC-bearing microorganism, Trichinella spiralis; in this case, there was no protection. These results were further supported by experiments with CFW mice which had been immunized to produce high levels of anti-PC antibodies but which were found to be just as susceptible to T. spiralis infection as nonimmunized animals.en_US
dc.languageengen_US
dc.publisherAmerican Society for Microbiology. The Journal's web site is located at http://iai.asm.org/en_US
dc.relation.ispartofInfection and Immunityen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibodies - Genetics - Immunologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshImmunizationen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Balb Cen_US
dc.subject.meshMice, Inbred Cbaen_US
dc.subject.meshMice, Transgenicen_US
dc.subject.meshPhosphorylcholine - Immunologyen_US
dc.subject.meshPneumococcal Infections - Immunologyen_US
dc.subject.meshTrichinella Spiralisen_US
dc.subject.meshTrichinellosis - Immunologyen_US
dc.titleTransgene-encoded antiphosphorylcholine (T15 +) antibodies protect CBA/N (xid) mice against infection with Streptococcus pneumoniae but not Trichinella spiralisen_US
dc.typeArticleen_US
dc.identifier.emailNg, SSM: ssmng@hku.hken_US
dc.identifier.authorityNg, SSM=rp00767en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8168926-
dc.identifier.scopuseid_2-s2.0-0028354872en_US
dc.identifier.volume62en_US
dc.identifier.issue5en_US
dc.identifier.spage1658en_US
dc.identifier.epage1661en_US
dc.identifier.isiWOS:A1994NH31300021-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridPak Leong Lim=7409531980en_US
dc.identifier.scopusauthoridChoy, WF=7006202365en_US
dc.identifier.scopusauthoridChan, STH=55455845100en_US
dc.identifier.scopusauthoridLeung, DTM=7203002802en_US
dc.identifier.scopusauthoridNg, SSM=7403358718en_US

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