File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: In vitro and in vivo evidence that dopamine exerts growth hormone- releasing activity in goldfish

TitleIn vitro and in vivo evidence that dopamine exerts growth hormone- releasing activity in goldfish
Authors
Issue Date1993
PublisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/
Citation
American Journal Of Physiology - Endocrinology And Metabolism, 1993, v. 264 n. 6 27-6, p. E925-E932 How to Cite?
AbstractWe have previously demonstrated that dopamine (DA) and the DA D1 agonist SKF 38393 stimulate growth hormone (GH) release from perifused pituitary fragments of the goldfish, suggesting an involvement of DA D1 receptors in GH regulation. In the present study, the role of DA on GH release and body growth of the goldfish was further investigated both in vivo and in vitro. DA consistently stimulated GH release in a dose-dependent manner from perifused goldfish pituitary fragments. The GH-releasing action of DA was seasonal, being the highest in sexually regressed fish, intermediate in recrudescent fish, and the lowest in sexually mature (prespawning) fish. Somatostatin, a known GH-release inhibitor in the goldfish, suppressed basal GH release and abolished the GH response to DA in perifused pituitary fragments as well as pituitary cells under static incubation. Intraperitoneal administration of the nonselective DA agonist apomorphine and the D1 agonist SKF 82958 increased the plasma GH levels in the goldfish. These GH responses were blocked by simultaneous treatment with the D1 antagonist Sch 23390 but not the D2 antagonist pimozide. Apomorphine administered orally also induced a similar elevation in plasma GH levels. Long-term feeding with apomorphine was found to be stimulatory to the body growth of goldfish. These results provide evidence that the neurotransmitter DA, by acting through DA D1 receptors in the pituitary, also functions as a GH-releasing factor in the goldfish.
Persistent Identifierhttp://hdl.handle.net/10722/178544
ISSN
1998 Impact Factor: 3.077
2004 SCImago Journal Rankings: 1.102
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, AOLen_US
dc.contributor.authorChang, JPen_US
dc.contributor.authorPeter, REen_US
dc.date.accessioned2012-12-19T09:48:17Z-
dc.date.available2012-12-19T09:48:17Z-
dc.date.issued1993en_US
dc.identifier.citationAmerican Journal Of Physiology - Endocrinology And Metabolism, 1993, v. 264 n. 6 27-6, p. E925-E932en_US
dc.identifier.issn0002-9513en_US
dc.identifier.urihttp://hdl.handle.net/10722/178544-
dc.description.abstractWe have previously demonstrated that dopamine (DA) and the DA D1 agonist SKF 38393 stimulate growth hormone (GH) release from perifused pituitary fragments of the goldfish, suggesting an involvement of DA D1 receptors in GH regulation. In the present study, the role of DA on GH release and body growth of the goldfish was further investigated both in vivo and in vitro. DA consistently stimulated GH release in a dose-dependent manner from perifused goldfish pituitary fragments. The GH-releasing action of DA was seasonal, being the highest in sexually regressed fish, intermediate in recrudescent fish, and the lowest in sexually mature (prespawning) fish. Somatostatin, a known GH-release inhibitor in the goldfish, suppressed basal GH release and abolished the GH response to DA in perifused pituitary fragments as well as pituitary cells under static incubation. Intraperitoneal administration of the nonselective DA agonist apomorphine and the D1 agonist SKF 82958 increased the plasma GH levels in the goldfish. These GH responses were blocked by simultaneous treatment with the D1 antagonist Sch 23390 but not the D2 antagonist pimozide. Apomorphine administered orally also induced a similar elevation in plasma GH levels. Long-term feeding with apomorphine was found to be stimulatory to the body growth of goldfish. These results provide evidence that the neurotransmitter DA, by acting through DA D1 receptors in the pituitary, also functions as a GH-releasing factor in the goldfish.en_US
dc.languageengen_US
dc.publisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/en_US
dc.relation.ispartofAmerican Journal of Physiology - Endocrinology and Metabolismen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAnimalsen_US
dc.subject.meshApomorphine - Pharmacologyen_US
dc.subject.meshBenzazepinesen_US
dc.subject.meshDopamine - Pharmacologyen_US
dc.subject.meshDopamine Agents - Pharmacologyen_US
dc.subject.meshGoldfish - Growth & Development - Metabolismen_US
dc.subject.meshGrowth Hormone - Blood - Metabolismen_US
dc.subject.meshGrowth Hormone-Releasing Hormone - Pharmacologyen_US
dc.subject.meshReceptors, Dopamine - Classification - Physiologyen_US
dc.subject.meshSeasonsen_US
dc.subject.meshSomatostatin - Pharmacologyen_US
dc.titleIn vitro and in vivo evidence that dopamine exerts growth hormone- releasing activity in goldfishen_US
dc.typeArticleen_US
dc.identifier.emailWong, AOL: olwong@hkucc.hku.hken_US
dc.identifier.authorityWong, AOL=rp00806en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8101429-
dc.identifier.scopuseid_2-s2.0-0027232393en_US
dc.identifier.volume264en_US
dc.identifier.issue6 27-6en_US
dc.identifier.spageE925en_US
dc.identifier.epageE932en_US
dc.identifier.isiWOS:A1993LL13200045-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWong, AOL=7403147570en_US
dc.identifier.scopusauthoridChang, JP=7601547649en_US
dc.identifier.scopusauthoridPeter, RE=7202909690en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats