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Article: Long-term feeding with structured lipid composed of medium-chain and N-3 fatty acids ameliorates endotoxic shock in guinea pigs

TitleLong-term feeding with structured lipid composed of medium-chain and N-3 fatty acids ameliorates endotoxic shock in guinea pigs
Authors
Issue Date1991
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/metabol
Citation
Metabolism: Clinical And Experimental, 1991, v. 40 n. 11, p. 1152-1159 How to Cite?
AbstractThe metabolic and physiologic responses to 7-hour endotoxin infusion (5.0 mg/kg h) were evaluated in guinea pigs following 6 weeks of dietary enrichment with diets containing either chemically structured lipid (SL) composed of medium-chain triglycerides (MCT) and long-chain triglycerides (LCT) in the form of N-3 polyunsaturated fatty acids (PUFAs), or safflower oil (SO), which is high in N-6 fatty acids. Plasma phospholipid fatty acid profiles, arterial blood pH, P(CO2), P(O2), HCO3, lactate, blood pressure, oxygen consumption, and energy expenditure were examined. Plasma phospholipid fatty acids profiles reflected dietary intake with SL-fed animals demonstrating a significantly higher N-3 to N-6 fatty acid ratio compared with SO-fed animals. SL-fed animals responded to endotoxemia with a mild metabolic acidosis with respiratory compensation, which was associated with moderate lactatemia (3 mmol/L). SO-fed animals developed a severe metabolic acidosis with acidemia and respiratory compensation, which was associated with hyperlactatemia (8 mmol/L,P < .05 v SL). No differences were observed in blood pressure, oxygen consumption, energy expenditure, or respiratory guotient during endotoxemia between dietary groups compared with controls. We conclude that diets enriched with structured lipid composed of medium-chain and N-3 fatty acids can attenuate the sequelae of endotoxemia.
Persistent Identifierhttp://hdl.handle.net/10722/178512
ISSN
2015 Impact Factor: 4.375
2015 SCImago Journal Rankings: 1.978
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTeo, TCen_US
dc.contributor.authorSelleck, KMen_US
dc.contributor.authorWan, JMFen_US
dc.contributor.authorPomposelli, JJen_US
dc.contributor.authorBabayan, VKen_US
dc.contributor.authorBlackburn, GLen_US
dc.contributor.authorBistrian, BRen_US
dc.date.accessioned2012-12-19T09:48:08Z-
dc.date.available2012-12-19T09:48:08Z-
dc.date.issued1991en_US
dc.identifier.citationMetabolism: Clinical And Experimental, 1991, v. 40 n. 11, p. 1152-1159en_US
dc.identifier.issn0026-0495en_US
dc.identifier.urihttp://hdl.handle.net/10722/178512-
dc.description.abstractThe metabolic and physiologic responses to 7-hour endotoxin infusion (5.0 mg/kg h) were evaluated in guinea pigs following 6 weeks of dietary enrichment with diets containing either chemically structured lipid (SL) composed of medium-chain triglycerides (MCT) and long-chain triglycerides (LCT) in the form of N-3 polyunsaturated fatty acids (PUFAs), or safflower oil (SO), which is high in N-6 fatty acids. Plasma phospholipid fatty acid profiles, arterial blood pH, P(CO2), P(O2), HCO3, lactate, blood pressure, oxygen consumption, and energy expenditure were examined. Plasma phospholipid fatty acids profiles reflected dietary intake with SL-fed animals demonstrating a significantly higher N-3 to N-6 fatty acid ratio compared with SO-fed animals. SL-fed animals responded to endotoxemia with a mild metabolic acidosis with respiratory compensation, which was associated with moderate lactatemia (3 mmol/L). SO-fed animals developed a severe metabolic acidosis with acidemia and respiratory compensation, which was associated with hyperlactatemia (8 mmol/L,P < .05 v SL). No differences were observed in blood pressure, oxygen consumption, energy expenditure, or respiratory guotient during endotoxemia between dietary groups compared with controls. We conclude that diets enriched with structured lipid composed of medium-chain and N-3 fatty acids can attenuate the sequelae of endotoxemia.en_US
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/metabolen_US
dc.relation.ispartofMetabolism: Clinical and Experimentalen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Pressureen_US
dc.subject.meshCalorimetry, Indirecten_US
dc.subject.meshDietary Fats - Pharmacologyen_US
dc.subject.meshFatty Acids - Blood - Pharmacologyen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshLactates - Blooden_US
dc.subject.meshLactic Aciden_US
dc.subject.meshLipids - Chemistry - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshPhospholipids - Blooden_US
dc.subject.meshShock, Septic - Metabolism - Physiopathologyen_US
dc.subject.meshTime Factorsen_US
dc.titleLong-term feeding with structured lipid composed of medium-chain and N-3 fatty acids ameliorates endotoxic shock in guinea pigsen_US
dc.typeArticleen_US
dc.identifier.emailWan, JMF: jmfwan@hku.hken_US
dc.identifier.authorityWan, JMF=rp00798en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0026-0495(91)90209-Fen_US
dc.identifier.pmid1943744-
dc.identifier.scopuseid_2-s2.0-0025989928en_US
dc.identifier.volume40en_US
dc.identifier.issue11en_US
dc.identifier.spage1152en_US
dc.identifier.epage1159en_US
dc.identifier.isiWOS:A1991GN83000007-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTeo, TC=16199070700en_US
dc.identifier.scopusauthoridSelleck, KM=6507595683en_US
dc.identifier.scopusauthoridWan, JMF=8930305000en_US
dc.identifier.scopusauthoridPomposelli, JJ=7003723819en_US
dc.identifier.scopusauthoridBabayan, VK=7003543287en_US
dc.identifier.scopusauthoridBlackburn, GL=7201722807en_US
dc.identifier.scopusauthoridBistrian, BR=35463916700en_US

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