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Article: Comparative effects of ω-3 and ω-6 polyunsaturated fatty acids on protein metabolism in rats bearing the mammary adenocarcinoma

TitleComparative effects of ω-3 and ω-6 polyunsaturated fatty acids on protein metabolism in rats bearing the mammary adenocarcinoma
Authors
Issue Date1991
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/metabol
Citation
Metabolism: Clinical And Experimental, 1991, v. 40 n. 6, p. 577-584 How to Cite?
AbstractThe comparative effects of diets containing 20% (wt/wt) of either fish oil (FO) or safflower oil (SO) on protein synthesis and catabolism were determined in rats bearing the 7,12-dimethylbenz(a)anthracene (DMBA) 13762 mammary adenocarcinoma in vivo using a 6-hour constant infusion of L-(1-14C)-leucine. Tumor-bearing animals fed FO had significantly lower tumor growth rate (36 ± 0.5 v 53 ± 0.7%/d, P < .05), total tumor protein synthesis (Ts) (1.25 ± 0.1 v 1.85 ± 0.1 μmol/h, P < .05), and tumor protein concentration (12.0 ± 0.5 v 14.0 ± 0.7%/d, P < 0.01). Tumor fractional synthetic rate and total protein breakdown rate of the tumor were unaffected by FO feeding. Both tumor-bearing and saline-control animals fed FO had significantly (P < .01) lower liver fractional synthetic rate and total protein breakdown rate, and higher liver total protein compared with SO-fed rats. Muscle protein kinetics were unaffected by either treatment or diet. Whole body protein kinetics were not affected by dietary treatment, but the presence of tumor significantly (P < .001) reduced whole body flux, synthesis, breakdown, and oxidation. Chronic FO feeding for 7 weeks significantly (P < .001) lowered ω-6 polyunsaturated fatty acids (ω-6 PUFAs) and significantly elevated ω-3 polyunsaturated fatty acids (ω-3 PUFAs) (P < .001) in both plasma phospholipid and triglycerides. The present study indicates that dietary FO can modulate mammary tumor growth in a manner that reflects changes in protein metabolism in both host and tumor tissues.
Persistent Identifierhttp://hdl.handle.net/10722/178506
ISSN
2015 Impact Factor: 4.375
2015 SCImago Journal Rankings: 1.978
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWan, JMFen_US
dc.contributor.authorIstfan, NWen_US
dc.contributor.authorChu, CCen_US
dc.contributor.authorBlackburn, GLen_US
dc.contributor.authorBistrian, BRen_US
dc.date.accessioned2012-12-19T09:48:06Z-
dc.date.available2012-12-19T09:48:06Z-
dc.date.issued1991en_US
dc.identifier.citationMetabolism: Clinical And Experimental, 1991, v. 40 n. 6, p. 577-584en_US
dc.identifier.issn0026-0495en_US
dc.identifier.urihttp://hdl.handle.net/10722/178506-
dc.description.abstractThe comparative effects of diets containing 20% (wt/wt) of either fish oil (FO) or safflower oil (SO) on protein synthesis and catabolism were determined in rats bearing the 7,12-dimethylbenz(a)anthracene (DMBA) 13762 mammary adenocarcinoma in vivo using a 6-hour constant infusion of L-(1-14C)-leucine. Tumor-bearing animals fed FO had significantly lower tumor growth rate (36 ± 0.5 v 53 ± 0.7%/d, P < .05), total tumor protein synthesis (Ts) (1.25 ± 0.1 v 1.85 ± 0.1 μmol/h, P < .05), and tumor protein concentration (12.0 ± 0.5 v 14.0 ± 0.7%/d, P < 0.01). Tumor fractional synthetic rate and total protein breakdown rate of the tumor were unaffected by FO feeding. Both tumor-bearing and saline-control animals fed FO had significantly (P < .01) lower liver fractional synthetic rate and total protein breakdown rate, and higher liver total protein compared with SO-fed rats. Muscle protein kinetics were unaffected by either treatment or diet. Whole body protein kinetics were not affected by dietary treatment, but the presence of tumor significantly (P < .001) reduced whole body flux, synthesis, breakdown, and oxidation. Chronic FO feeding for 7 weeks significantly (P < .001) lowered ω-6 polyunsaturated fatty acids (ω-6 PUFAs) and significantly elevated ω-3 polyunsaturated fatty acids (ω-3 PUFAs) (P < .001) in both plasma phospholipid and triglycerides. The present study indicates that dietary FO can modulate mammary tumor growth in a manner that reflects changes in protein metabolism in both host and tumor tissues.en_US
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/metabolen_US
dc.relation.ispartofMetabolism: Clinical and Experimentalen_US
dc.subject.mesh9,10-Dimethyl-1,2-Benzanthraceneen_US
dc.subject.meshAdenocarcinoma - Blood Supply - Chemically Induced - Metabolism - Pathologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCarbon Radioisotopesen_US
dc.subject.meshDietary Fats - Pharmacologyen_US
dc.subject.meshFatty Acids, Nonesterified - Blooden_US
dc.subject.meshFatty Acids, Omega-3 - Pharmacologyen_US
dc.subject.meshFatty Acids, Omega-6en_US
dc.subject.meshFatty Acids, Unsaturated - Pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFish Oils - Pharmacologyen_US
dc.subject.meshKineticsen_US
dc.subject.meshLeucine - Metabolismen_US
dc.subject.meshLiver - Drug Effects - Metabolismen_US
dc.subject.meshMammary Neoplasms, Experimental - Blood Supply - Metabolism - Pathologyen_US
dc.subject.meshMuscle Proteins - Metabolismen_US
dc.subject.meshMuscles - Blood Supply - Drug Effects - Metabolismen_US
dc.subject.meshProteins - Metabolismen_US
dc.subject.meshRadioisotope Dilution Techniqueen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred F344en_US
dc.subject.meshRegional Blood Flowen_US
dc.subject.meshSafflower Oil - Pharmacologyen_US
dc.titleComparative effects of ω-3 and ω-6 polyunsaturated fatty acids on protein metabolism in rats bearing the mammary adenocarcinomaen_US
dc.typeArticleen_US
dc.identifier.emailWan, JMF: jmfwan@hku.hken_US
dc.identifier.authorityWan, JMF=rp00798en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0026-0495(91)90047-Zen_US
dc.identifier.pmid1907711-
dc.identifier.scopuseid_2-s2.0-0025825606en_US
dc.identifier.volume40en_US
dc.identifier.issue6en_US
dc.identifier.spage577en_US
dc.identifier.epage584en_US
dc.identifier.isiWOS:A1991FN65800005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWan, JMF=8930305000en_US
dc.identifier.scopusauthoridIstfan, NW=7003819779en_US
dc.identifier.scopusauthoridChu, CC=24350985600en_US
dc.identifier.scopusauthoridBlackburn, GL=7201722807en_US
dc.identifier.scopusauthoridBistrian, BR=35463916700en_US

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