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- Publisher Website: 10.1016/0026-0495(91)90047-Z
- Scopus: eid_2-s2.0-0025825606
- PMID: 1907711
- WOS: WOS:A1991FN65800005
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Article: Comparative effects of ω-3 and ω-6 polyunsaturated fatty acids on protein metabolism in rats bearing the mammary adenocarcinoma
Title | Comparative effects of ω-3 and ω-6 polyunsaturated fatty acids on protein metabolism in rats bearing the mammary adenocarcinoma |
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Authors | |
Issue Date | 1991 |
Publisher | WB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/metabol |
Citation | Metabolism: Clinical And Experimental, 1991, v. 40 n. 6, p. 577-584 How to Cite? |
Abstract | The comparative effects of diets containing 20% (wt/wt) of either fish oil (FO) or safflower oil (SO) on protein synthesis and catabolism were determined in rats bearing the 7,12-dimethylbenz(a)anthracene (DMBA) 13762 mammary adenocarcinoma in vivo using a 6-hour constant infusion of L-(1-14C)-leucine. Tumor-bearing animals fed FO had significantly lower tumor growth rate (36 ± 0.5 v 53 ± 0.7%/d, P < .05), total tumor protein synthesis (Ts) (1.25 ± 0.1 v 1.85 ± 0.1 μmol/h, P < .05), and tumor protein concentration (12.0 ± 0.5 v 14.0 ± 0.7%/d, P < 0.01). Tumor fractional synthetic rate and total protein breakdown rate of the tumor were unaffected by FO feeding. Both tumor-bearing and saline-control animals fed FO had significantly (P < .01) lower liver fractional synthetic rate and total protein breakdown rate, and higher liver total protein compared with SO-fed rats. Muscle protein kinetics were unaffected by either treatment or diet. Whole body protein kinetics were not affected by dietary treatment, but the presence of tumor significantly (P < .001) reduced whole body flux, synthesis, breakdown, and oxidation. Chronic FO feeding for 7 weeks significantly (P < .001) lowered ω-6 polyunsaturated fatty acids (ω-6 PUFAs) and significantly elevated ω-3 polyunsaturated fatty acids (ω-3 PUFAs) (P < .001) in both plasma phospholipid and triglycerides. The present study indicates that dietary FO can modulate mammary tumor growth in a manner that reflects changes in protein metabolism in both host and tumor tissues. |
Persistent Identifier | http://hdl.handle.net/10722/178506 |
ISSN | 2023 Impact Factor: 10.8 2023 SCImago Journal Rankings: 2.792 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wan, JMF | en_US |
dc.contributor.author | Istfan, NW | en_US |
dc.contributor.author | Chu, CC | en_US |
dc.contributor.author | Blackburn, GL | en_US |
dc.contributor.author | Bistrian, BR | en_US |
dc.date.accessioned | 2012-12-19T09:48:06Z | - |
dc.date.available | 2012-12-19T09:48:06Z | - |
dc.date.issued | 1991 | en_US |
dc.identifier.citation | Metabolism: Clinical And Experimental, 1991, v. 40 n. 6, p. 577-584 | en_US |
dc.identifier.issn | 0026-0495 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/178506 | - |
dc.description.abstract | The comparative effects of diets containing 20% (wt/wt) of either fish oil (FO) or safflower oil (SO) on protein synthesis and catabolism were determined in rats bearing the 7,12-dimethylbenz(a)anthracene (DMBA) 13762 mammary adenocarcinoma in vivo using a 6-hour constant infusion of L-(1-14C)-leucine. Tumor-bearing animals fed FO had significantly lower tumor growth rate (36 ± 0.5 v 53 ± 0.7%/d, P < .05), total tumor protein synthesis (Ts) (1.25 ± 0.1 v 1.85 ± 0.1 μmol/h, P < .05), and tumor protein concentration (12.0 ± 0.5 v 14.0 ± 0.7%/d, P < 0.01). Tumor fractional synthetic rate and total protein breakdown rate of the tumor were unaffected by FO feeding. Both tumor-bearing and saline-control animals fed FO had significantly (P < .01) lower liver fractional synthetic rate and total protein breakdown rate, and higher liver total protein compared with SO-fed rats. Muscle protein kinetics were unaffected by either treatment or diet. Whole body protein kinetics were not affected by dietary treatment, but the presence of tumor significantly (P < .001) reduced whole body flux, synthesis, breakdown, and oxidation. Chronic FO feeding for 7 weeks significantly (P < .001) lowered ω-6 polyunsaturated fatty acids (ω-6 PUFAs) and significantly elevated ω-3 polyunsaturated fatty acids (ω-3 PUFAs) (P < .001) in both plasma phospholipid and triglycerides. The present study indicates that dietary FO can modulate mammary tumor growth in a manner that reflects changes in protein metabolism in both host and tumor tissues. | en_US |
dc.language | eng | en_US |
dc.publisher | WB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/metabol | en_US |
dc.relation.ispartof | Metabolism: Clinical and Experimental | en_US |
dc.subject.mesh | 9,10-Dimethyl-1,2-Benzanthracene | en_US |
dc.subject.mesh | Adenocarcinoma - Blood Supply - Chemically Induced - Metabolism - Pathology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Carbon Radioisotopes | en_US |
dc.subject.mesh | Dietary Fats - Pharmacology | en_US |
dc.subject.mesh | Fatty Acids, Nonesterified - Blood | en_US |
dc.subject.mesh | Fatty Acids, Omega-3 - Pharmacology | en_US |
dc.subject.mesh | Fatty Acids, Omega-6 | en_US |
dc.subject.mesh | Fatty Acids, Unsaturated - Pharmacology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Fish Oils - Pharmacology | en_US |
dc.subject.mesh | Kinetics | en_US |
dc.subject.mesh | Leucine - Metabolism | en_US |
dc.subject.mesh | Liver - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Mammary Neoplasms, Experimental - Blood Supply - Metabolism - Pathology | en_US |
dc.subject.mesh | Muscle Proteins - Metabolism | en_US |
dc.subject.mesh | Muscles - Blood Supply - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Proteins - Metabolism | en_US |
dc.subject.mesh | Radioisotope Dilution Technique | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Inbred F344 | en_US |
dc.subject.mesh | Regional Blood Flow | en_US |
dc.subject.mesh | Safflower Oil - Pharmacology | en_US |
dc.title | Comparative effects of ω-3 and ω-6 polyunsaturated fatty acids on protein metabolism in rats bearing the mammary adenocarcinoma | en_US |
dc.type | Article | en_US |
dc.identifier.email | Wan, JMF: jmfwan@hku.hk | en_US |
dc.identifier.authority | Wan, JMF=rp00798 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0026-0495(91)90047-Z | en_US |
dc.identifier.pmid | 1907711 | - |
dc.identifier.scopus | eid_2-s2.0-0025825606 | en_US |
dc.identifier.volume | 40 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | 577 | en_US |
dc.identifier.epage | 584 | en_US |
dc.identifier.isi | WOS:A1991FN65800005 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Wan, JMF=8930305000 | en_US |
dc.identifier.scopusauthorid | Istfan, NW=7003819779 | en_US |
dc.identifier.scopusauthorid | Chu, CC=24350985600 | en_US |
dc.identifier.scopusauthorid | Blackburn, GL=7201722807 | en_US |
dc.identifier.scopusauthorid | Bistrian, BR=35463916700 | en_US |
dc.identifier.issnl | 0026-0495 | - |