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Article: Selective increase in carbohydrate intake by rats treated with 8-hydroxy-2-(di-n-propylamino)-tetraline or buspirone

TitleSelective increase in carbohydrate intake by rats treated with 8-hydroxy-2-(di-n-propylamino)-tetraline or buspirone
Authors
Issue Date1990
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 1990, v. 46 n. 23, p. 1643-1648 How to Cite?
AbstractBoth 8-hydroxy-2-(di-n-propylamino)-tetraline (8-OH-DPAT) and buspirone (BUSP) were found to induce food intake in free-feeding, self-selecting young rats. The hyperphagia was macronutrient specific. In rats given simultaneous access to two diets which differed in carbohydrate and protein content, 8-OH-DPAT and BUSP selectively increased intake from the diet with high carbohydrate content during a two hour test. This specific behavioral effect is dose-dependent and is opposite to that induced by serotonin releasers or reuptake inhibitors. In a separate experiment, the selective decrease in carbohydrate intake after fluoxetine (FLX) was blocked by 8-OH-DPAT co-administration. These results further support a role for the serotonergic system in the control of feeding and macronutrient specific appetites.
Persistent Identifierhttp://hdl.handle.net/10722/178492
ISSN
2015 Impact Factor: 2.685
2015 SCImago Journal Rankings: 1.056

 

DC FieldValueLanguage
dc.contributor.authorLuo, Sen_US
dc.contributor.authorRansom, Ten_US
dc.contributor.authorLi, ETSen_US
dc.date.accessioned2012-12-19T09:48:00Z-
dc.date.available2012-12-19T09:48:00Z-
dc.date.issued1990en_US
dc.identifier.citationLife Sciences, 1990, v. 46 n. 23, p. 1643-1648en_US
dc.identifier.issn0024-3205en_US
dc.identifier.urihttp://hdl.handle.net/10722/178492-
dc.description.abstractBoth 8-hydroxy-2-(di-n-propylamino)-tetraline (8-OH-DPAT) and buspirone (BUSP) were found to induce food intake in free-feeding, self-selecting young rats. The hyperphagia was macronutrient specific. In rats given simultaneous access to two diets which differed in carbohydrate and protein content, 8-OH-DPAT and BUSP selectively increased intake from the diet with high carbohydrate content during a two hour test. This specific behavioral effect is dose-dependent and is opposite to that induced by serotonin releasers or reuptake inhibitors. In a separate experiment, the selective decrease in carbohydrate intake after fluoxetine (FLX) was blocked by 8-OH-DPAT co-administration. These results further support a role for the serotonergic system in the control of feeding and macronutrient specific appetites.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescieen_US
dc.relation.ispartofLife Sciencesen_US
dc.subject.mesh8-Hydroxy-2-(Di-N-Propylamino)Tetralinen_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBuspirone - Pharmacologyen_US
dc.subject.meshDietary Carbohydrates - Metabolismen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshEating - Drug Effectsen_US
dc.subject.meshFluoxetine - Pharmacologyen_US
dc.subject.meshFood Preferences - Drug Effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshNaphthalenes - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshTetrahydronaphthalenes - Pharmacologyen_US
dc.titleSelective increase in carbohydrate intake by rats treated with 8-hydroxy-2-(di-n-propylamino)-tetraline or buspironeen_US
dc.typeArticleen_US
dc.identifier.emailLi, ETS: etsli@hku.hken_US
dc.identifier.authorityLi, ETS=rp00737en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0024-3205(90)90378-5en_US
dc.identifier.pmid2141379-
dc.identifier.scopuseid_2-s2.0-0025295451en_US
dc.identifier.volume46en_US
dc.identifier.issue23en_US
dc.identifier.spage1643en_US
dc.identifier.epage1648en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLuo, S=16151581100en_US
dc.identifier.scopusauthoridRansom, T=6602352938en_US
dc.identifier.scopusauthoridLi, ETS=14018169600en_US

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