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- Publisher Website: 10.1016/0024-3205(90)90378-5
- Scopus: eid_2-s2.0-0025295451
- PMID: 2141379
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Article: Selective increase in carbohydrate intake by rats treated with 8-hydroxy-2-(di-n-propylamino)-tetraline or buspirone
Title | Selective increase in carbohydrate intake by rats treated with 8-hydroxy-2-(di-n-propylamino)-tetraline or buspirone |
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Authors | |
Issue Date | 1990 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie |
Citation | Life Sciences, 1990, v. 46 n. 23, p. 1643-1648 How to Cite? |
Abstract | Both 8-hydroxy-2-(di-n-propylamino)-tetraline (8-OH-DPAT) and buspirone (BUSP) were found to induce food intake in free-feeding, self-selecting young rats. The hyperphagia was macronutrient specific. In rats given simultaneous access to two diets which differed in carbohydrate and protein content, 8-OH-DPAT and BUSP selectively increased intake from the diet with high carbohydrate content during a two hour test. This specific behavioral effect is dose-dependent and is opposite to that induced by serotonin releasers or reuptake inhibitors. In a separate experiment, the selective decrease in carbohydrate intake after fluoxetine (FLX) was blocked by 8-OH-DPAT co-administration. These results further support a role for the serotonergic system in the control of feeding and macronutrient specific appetites. |
Persistent Identifier | http://hdl.handle.net/10722/178492 |
ISSN | 2023 Impact Factor: 5.2 2023 SCImago Journal Rankings: 1.257 |
DC Field | Value | Language |
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dc.contributor.author | Luo, S | en_US |
dc.contributor.author | Ransom, T | en_US |
dc.contributor.author | Li, ETS | en_US |
dc.date.accessioned | 2012-12-19T09:48:00Z | - |
dc.date.available | 2012-12-19T09:48:00Z | - |
dc.date.issued | 1990 | en_US |
dc.identifier.citation | Life Sciences, 1990, v. 46 n. 23, p. 1643-1648 | en_US |
dc.identifier.issn | 0024-3205 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/178492 | - |
dc.description.abstract | Both 8-hydroxy-2-(di-n-propylamino)-tetraline (8-OH-DPAT) and buspirone (BUSP) were found to induce food intake in free-feeding, self-selecting young rats. The hyperphagia was macronutrient specific. In rats given simultaneous access to two diets which differed in carbohydrate and protein content, 8-OH-DPAT and BUSP selectively increased intake from the diet with high carbohydrate content during a two hour test. This specific behavioral effect is dose-dependent and is opposite to that induced by serotonin releasers or reuptake inhibitors. In a separate experiment, the selective decrease in carbohydrate intake after fluoxetine (FLX) was blocked by 8-OH-DPAT co-administration. These results further support a role for the serotonergic system in the control of feeding and macronutrient specific appetites. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie | en_US |
dc.relation.ispartof | Life Sciences | en_US |
dc.subject.mesh | 8-Hydroxy-2-(Di-N-Propylamino)Tetralin | en_US |
dc.subject.mesh | Analysis Of Variance | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Buspirone - Pharmacology | en_US |
dc.subject.mesh | Dietary Carbohydrates - Metabolism | en_US |
dc.subject.mesh | Dose-Response Relationship, Drug | en_US |
dc.subject.mesh | Drug Interactions | en_US |
dc.subject.mesh | Eating - Drug Effects | en_US |
dc.subject.mesh | Fluoxetine - Pharmacology | en_US |
dc.subject.mesh | Food Preferences - Drug Effects | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Naphthalenes - Pharmacology | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Inbred Strains | en_US |
dc.subject.mesh | Tetrahydronaphthalenes - Pharmacology | en_US |
dc.title | Selective increase in carbohydrate intake by rats treated with 8-hydroxy-2-(di-n-propylamino)-tetraline or buspirone | en_US |
dc.type | Article | en_US |
dc.identifier.email | Li, ETS: etsli@hku.hk | en_US |
dc.identifier.authority | Li, ETS=rp00737 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0024-3205(90)90378-5 | en_US |
dc.identifier.pmid | 2141379 | - |
dc.identifier.scopus | eid_2-s2.0-0025295451 | en_US |
dc.identifier.volume | 46 | en_US |
dc.identifier.issue | 23 | en_US |
dc.identifier.spage | 1643 | en_US |
dc.identifier.epage | 1648 | en_US |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Luo, S=16151581100 | en_US |
dc.identifier.scopusauthorid | Ransom, T=6602352938 | en_US |
dc.identifier.scopusauthorid | Li, ETS=14018169600 | en_US |
dc.identifier.issnl | 0024-3205 | - |