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Article: Secretion of activin by interstitial cells in the testis

TitleSecretion of activin by interstitial cells in the testis
Authors
Issue Date1989
PublisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org
Citation
Science, 1989, v. 243 n. 4889, p. 396-398 How to Cite?
AbstractActivin, a dimer formed by the β subunits of inhibin, has an effect that is opposite to that of inhibin in a number of biological systems. Which cell types secrete activin in vivo is not known. TM3 cells, a Leydig-derived cell line, contained messenger RNAs that hybridized with human β(A) and β(B) complementary DNA probes and were similar in size to the porcine messenger RNA for the β subunits of inhibin. No hybridization to the inhibin α subunit was detectable in the TM3 cells. Conditioned medium from TM3 cells and from primary cultures of rat and porcine interstitial cells stimulated the release of follicle-stimulating hormone in a pituitary cell culture assay. It is likely that, in the testis, the Leydig cells secrete activin and the Sertoli cells produce inhibin, or a combination of both.
Persistent Identifierhttp://hdl.handle.net/10722/178471
ISSN
2015 Impact Factor: 34.661
2015 SCImago Journal Rankings: 13.217
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, Wen_US
dc.contributor.authorMason, AJen_US
dc.contributor.authorSchwall, Ren_US
dc.contributor.authorSzonyi, Een_US
dc.contributor.authorMather, JPen_US
dc.date.accessioned2012-12-19T09:47:53Z-
dc.date.available2012-12-19T09:47:53Z-
dc.date.issued1989en_US
dc.identifier.citationScience, 1989, v. 243 n. 4889, p. 396-398en_US
dc.identifier.issn0036-8075en_US
dc.identifier.urihttp://hdl.handle.net/10722/178471-
dc.description.abstractActivin, a dimer formed by the β subunits of inhibin, has an effect that is opposite to that of inhibin in a number of biological systems. Which cell types secrete activin in vivo is not known. TM3 cells, a Leydig-derived cell line, contained messenger RNAs that hybridized with human β(A) and β(B) complementary DNA probes and were similar in size to the porcine messenger RNA for the β subunits of inhibin. No hybridization to the inhibin α subunit was detectable in the TM3 cells. Conditioned medium from TM3 cells and from primary cultures of rat and porcine interstitial cells stimulated the release of follicle-stimulating hormone in a pituitary cell culture assay. It is likely that, in the testis, the Leydig cells secrete activin and the Sertoli cells produce inhibin, or a combination of both.en_US
dc.languageengen_US
dc.publisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.orgen_US
dc.relation.ispartofScienceen_US
dc.subject.meshActivinsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Lineen_US
dc.subject.meshFollicle Stimulating Hormone - Secretionen_US
dc.subject.meshInhibins - Physiology - Secretionen_US
dc.subject.meshLeydig Cells - Physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshRatsen_US
dc.subject.meshSertoli Cells - Physiologyen_US
dc.subject.meshSwineen_US
dc.subject.meshTestis - Cytology - Physiologyen_US
dc.titleSecretion of activin by interstitial cells in the testisen_US
dc.typeArticleen_US
dc.identifier.emailLee, W: hrszlwm@hku.hken_US
dc.identifier.authorityLee, W=rp00728en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1126/science.2492117-
dc.identifier.pmid2492117-
dc.identifier.scopuseid_2-s2.0-0024575098en_US
dc.identifier.volume243en_US
dc.identifier.issue4889en_US
dc.identifier.spage396en_US
dc.identifier.epage398en_US
dc.identifier.isiWOS:A1989R832400042-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLee, W=24799156600en_US
dc.identifier.scopusauthoridMason, AJ=7203074342en_US
dc.identifier.scopusauthoridSchwall, R=7007140996en_US
dc.identifier.scopusauthoridSzonyi, E=6602753249en_US
dc.identifier.scopusauthoridMather, JP=35512944300en_US

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