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Article: Route of delivery of phenylalanine influences its effect on short-term food intake in adult male rats

TitleRoute of delivery of phenylalanine influences its effect on short-term food intake in adult male rats
Authors
Issue Date1989
PublisherAmerican Society for Nutrition. The Journal's web site is located at http://jn.nutrition.org
Citation
Journal Of Nutrition, 1989, v. 119 n. 10, p. 1519-1527 How to Cite?
AbstractThe effect of phenylalanine (Phe) on plasma and brain Phe and tyrosine (Tyr) levels and on short-term food intake in male rats was measured after intragastric (i.g.), subcutaneous (s.c.) and intraperitoneal (i.p.) administration. Compared to equimolar alanine (Ala), which served as the control, Phe significantly suppressed feeding at a dose of 90 mg/kg body wt when given i.p., but doses up to 720 mg/kg body wt had no effect when given i.g. or s.c. The high doses of Phe given by the i.g. or s.c. route resulted in higher levels of Phe in both plasma and brain than those following i.p. injection (90 mg/kg body wt). Furthermore, brain Tyr levels after i.g. Phe (720 mg/kg body wt) were equal to or higher than after i.p. Phe (90 mg/kg body wt). We conclude that the route of administration is an important variable influencing the effects of Phe on feeding behavior, and that these effects are not readily explained by plasma or brain Phe and Tyr concentrations.
Persistent Identifierhttp://hdl.handle.net/10722/178467
ISSN
2015 Impact Factor: 3.74
2015 SCImago Journal Rankings: 2.040
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBialik, RJen_US
dc.contributor.authorLi, ETSen_US
dc.contributor.authorGeoffroy, Pen_US
dc.contributor.authorAnderson, GHen_US
dc.date.accessioned2012-12-19T09:47:51Z-
dc.date.available2012-12-19T09:47:51Z-
dc.date.issued1989en_US
dc.identifier.citationJournal Of Nutrition, 1989, v. 119 n. 10, p. 1519-1527en_US
dc.identifier.issn0022-3166en_US
dc.identifier.urihttp://hdl.handle.net/10722/178467-
dc.description.abstractThe effect of phenylalanine (Phe) on plasma and brain Phe and tyrosine (Tyr) levels and on short-term food intake in male rats was measured after intragastric (i.g.), subcutaneous (s.c.) and intraperitoneal (i.p.) administration. Compared to equimolar alanine (Ala), which served as the control, Phe significantly suppressed feeding at a dose of 90 mg/kg body wt when given i.p., but doses up to 720 mg/kg body wt had no effect when given i.g. or s.c. The high doses of Phe given by the i.g. or s.c. route resulted in higher levels of Phe in both plasma and brain than those following i.p. injection (90 mg/kg body wt). Furthermore, brain Tyr levels after i.g. Phe (720 mg/kg body wt) were equal to or higher than after i.p. Phe (90 mg/kg body wt). We conclude that the route of administration is an important variable influencing the effects of Phe on feeding behavior, and that these effects are not readily explained by plasma or brain Phe and Tyr concentrations.en_US
dc.languageengen_US
dc.publisherAmerican Society for Nutrition. The Journal's web site is located at http://jn.nutrition.orgen_US
dc.relation.ispartofJournal of Nutritionen_US
dc.subject.meshAlanine - Administration & Dosage - Metabolism - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBrain Chemistry - Drug Effectsen_US
dc.subject.meshEnergy Intake - Drug Effectsen_US
dc.subject.meshInjections, Intraperitonealen_US
dc.subject.meshInjections, Subcutaneousen_US
dc.subject.meshIntubation, Gastrointestinalen_US
dc.subject.meshLiver - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshPhenylalanine - Administration & Dosage - Metabolism - Pharmacologyen_US
dc.subject.meshPlasma - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.titleRoute of delivery of phenylalanine influences its effect on short-term food intake in adult male ratsen_US
dc.typeArticleen_US
dc.identifier.emailLi, ETS: etsli@hku.hken_US
dc.identifier.authorityLi, ETS=rp00737en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2585142-
dc.identifier.scopuseid_2-s2.0-0024368443en_US
dc.identifier.volume119en_US
dc.identifier.issue10en_US
dc.identifier.spage1519en_US
dc.identifier.epage1527en_US
dc.identifier.isiWOS:A1989CB36500026-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridBialik, RJ=6602857521en_US
dc.identifier.scopusauthoridLi, ETS=14018169600en_US
dc.identifier.scopusauthoridGeoffroy, P=7004193557en_US
dc.identifier.scopusauthoridAnderson, GH=7404223441en_US

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