File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Invited comment: Lipids and the development of immune dysfunction and infection

TitleInvited comment: Lipids and the development of immune dysfunction and infection
Authors
Issue Date1988
PublisherSage Publications, Inc.. The Journal's web site is located at http://pen.sagepub.com
Citation
Journal Of Parenteral And Enteral Nutrition, 1988, v. 12 n. 6 SUPPL., p. 43S-48S How to Cite?
AbstractExcessive W-6 PUFA metabolism due to high levels of dietary fat intake can encourage infection via prolonged inflammation, enhanced Gram negative survival, reticuloendothelial blockage, immunosuppression, and monokine depression. Lipids can influence host immunity by altering eicosanoid metabolism and membrane structure and function. Further investigations are essential to answer questions regarding the levels and properties of various essential fatty acids in TPN lipid emulsions. Combining the features of LCT in the form of W-3 PUFA (fish oil) and MCT in the form of medium-chain triglyceride in a 'stuctured lipid' may decrease infection and may improve survival rates by producing fewer inflammatory eicosanoids of the two- and four-series, and serving as a more 'efficient fuel'. The introduction of W-3 polyunsaturated fatty acids into the TPN emulsions as well as into normal diets may provide an important therapeutic advance in the pathogenesis of disease. Such unique antiinflammatory properties of W-3 PUFA require intensive research.
Persistent Identifierhttp://hdl.handle.net/10722/178465
ISSN
2015 Impact Factor: 3.517
2015 SCImago Journal Rankings: 1.149
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWan, JMFen_US
dc.contributor.authorTeo, TCen_US
dc.contributor.authorKabayan, VKen_US
dc.contributor.authorBlackburn, GLen_US
dc.date.accessioned2012-12-19T09:47:51Z-
dc.date.available2012-12-19T09:47:51Z-
dc.date.issued1988en_US
dc.identifier.citationJournal Of Parenteral And Enteral Nutrition, 1988, v. 12 n. 6 SUPPL., p. 43S-48Sen_US
dc.identifier.issn0148-6071en_US
dc.identifier.urihttp://hdl.handle.net/10722/178465-
dc.description.abstractExcessive W-6 PUFA metabolism due to high levels of dietary fat intake can encourage infection via prolonged inflammation, enhanced Gram negative survival, reticuloendothelial blockage, immunosuppression, and monokine depression. Lipids can influence host immunity by altering eicosanoid metabolism and membrane structure and function. Further investigations are essential to answer questions regarding the levels and properties of various essential fatty acids in TPN lipid emulsions. Combining the features of LCT in the form of W-3 PUFA (fish oil) and MCT in the form of medium-chain triglyceride in a 'stuctured lipid' may decrease infection and may improve survival rates by producing fewer inflammatory eicosanoids of the two- and four-series, and serving as a more 'efficient fuel'. The introduction of W-3 polyunsaturated fatty acids into the TPN emulsions as well as into normal diets may provide an important therapeutic advance in the pathogenesis of disease. Such unique antiinflammatory properties of W-3 PUFA require intensive research.en_US
dc.languageengen_US
dc.publisherSage Publications, Inc.. The Journal's web site is located at http://pen.sagepub.comen_US
dc.relation.ispartofJournal of Parenteral and Enteral Nutritionen_US
dc.subject.meshAnimalsen_US
dc.subject.meshFat Emulsions, Intravenous - Metabolism - Therapeutic Useen_US
dc.subject.meshFatty Acids, Unsaturated - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshImmune System Diseases - Drug Therapy - Metabolismen_US
dc.subject.meshInfection - Drug Therapy - Metabolismen_US
dc.titleInvited comment: Lipids and the development of immune dysfunction and infectionen_US
dc.typeArticleen_US
dc.identifier.emailWan, JMF: jmfwan@hku.hken_US
dc.identifier.authorityWan, JMF=rp00798en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1177/014860718801200603-
dc.identifier.pmid3063838-
dc.identifier.scopuseid_2-s2.0-0024243010en_US
dc.identifier.volume12en_US
dc.identifier.issue6 SUPPL.en_US
dc.identifier.spage43Sen_US
dc.identifier.epage48Sen_US
dc.identifier.isiWOS:A1988R193300003-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWan, JMF=8930305000en_US
dc.identifier.scopusauthoridTeo, TC=16199070700en_US
dc.identifier.scopusauthoridKabayan, VK=6504500916en_US
dc.identifier.scopusauthoridBlackburn, GL=7201722807en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats