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- Publisher Website: 10.1177/014860718801200603
- Scopus: eid_2-s2.0-0024243010
- PMID: 3063838
- WOS: WOS:A1988R193300003
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Article: Invited comment: Lipids and the development of immune dysfunction and infection
Title | Invited comment: Lipids and the development of immune dysfunction and infection |
---|---|
Authors | |
Issue Date | 1988 |
Publisher | Sage Publications, Inc.. The Journal's web site is located at http://pen.sagepub.com |
Citation | Journal Of Parenteral And Enteral Nutrition, 1988, v. 12 n. 6 SUPPL., p. 43S-48S How to Cite? |
Abstract | Excessive W-6 PUFA metabolism due to high levels of dietary fat intake can encourage infection via prolonged inflammation, enhanced Gram negative survival, reticuloendothelial blockage, immunosuppression, and monokine depression. Lipids can influence host immunity by altering eicosanoid metabolism and membrane structure and function. Further investigations are essential to answer questions regarding the levels and properties of various essential fatty acids in TPN lipid emulsions. Combining the features of LCT in the form of W-3 PUFA (fish oil) and MCT in the form of medium-chain triglyceride in a 'stuctured lipid' may decrease infection and may improve survival rates by producing fewer inflammatory eicosanoids of the two- and four-series, and serving as a more 'efficient fuel'. The introduction of W-3 polyunsaturated fatty acids into the TPN emulsions as well as into normal diets may provide an important therapeutic advance in the pathogenesis of disease. Such unique antiinflammatory properties of W-3 PUFA require intensive research. |
Persistent Identifier | http://hdl.handle.net/10722/178465 |
ISSN | 2023 Impact Factor: 3.2 2023 SCImago Journal Rankings: 1.038 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wan, JMF | en_US |
dc.contributor.author | Teo, TC | en_US |
dc.contributor.author | Kabayan, VK | en_US |
dc.contributor.author | Blackburn, GL | en_US |
dc.date.accessioned | 2012-12-19T09:47:51Z | - |
dc.date.available | 2012-12-19T09:47:51Z | - |
dc.date.issued | 1988 | en_US |
dc.identifier.citation | Journal Of Parenteral And Enteral Nutrition, 1988, v. 12 n. 6 SUPPL., p. 43S-48S | en_US |
dc.identifier.issn | 0148-6071 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/178465 | - |
dc.description.abstract | Excessive W-6 PUFA metabolism due to high levels of dietary fat intake can encourage infection via prolonged inflammation, enhanced Gram negative survival, reticuloendothelial blockage, immunosuppression, and monokine depression. Lipids can influence host immunity by altering eicosanoid metabolism and membrane structure and function. Further investigations are essential to answer questions regarding the levels and properties of various essential fatty acids in TPN lipid emulsions. Combining the features of LCT in the form of W-3 PUFA (fish oil) and MCT in the form of medium-chain triglyceride in a 'stuctured lipid' may decrease infection and may improve survival rates by producing fewer inflammatory eicosanoids of the two- and four-series, and serving as a more 'efficient fuel'. The introduction of W-3 polyunsaturated fatty acids into the TPN emulsions as well as into normal diets may provide an important therapeutic advance in the pathogenesis of disease. Such unique antiinflammatory properties of W-3 PUFA require intensive research. | en_US |
dc.language | eng | en_US |
dc.publisher | Sage Publications, Inc.. The Journal's web site is located at http://pen.sagepub.com | en_US |
dc.relation.ispartof | Journal of Parenteral and Enteral Nutrition | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Fat Emulsions, Intravenous - Metabolism - Therapeutic Use | en_US |
dc.subject.mesh | Fatty Acids, Unsaturated - Metabolism | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Immune System Diseases - Drug Therapy - Metabolism | en_US |
dc.subject.mesh | Infection - Drug Therapy - Metabolism | en_US |
dc.title | Invited comment: Lipids and the development of immune dysfunction and infection | en_US |
dc.type | Article | en_US |
dc.identifier.email | Wan, JMF: jmfwan@hku.hk | en_US |
dc.identifier.authority | Wan, JMF=rp00798 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1177/014860718801200603 | - |
dc.identifier.pmid | 3063838 | - |
dc.identifier.scopus | eid_2-s2.0-0024243010 | en_US |
dc.identifier.volume | 12 | en_US |
dc.identifier.issue | 6 SUPPL. | en_US |
dc.identifier.spage | 43S | en_US |
dc.identifier.epage | 48S | en_US |
dc.identifier.isi | WOS:A1988R193300003 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Wan, JMF=8930305000 | en_US |
dc.identifier.scopusauthorid | Teo, TC=16199070700 | en_US |
dc.identifier.scopusauthorid | Kabayan, VK=6504500916 | en_US |
dc.identifier.scopusauthorid | Blackburn, GL=7201722807 | en_US |
dc.identifier.issnl | 0148-6071 | - |