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Article: Ontogenesis of immunocytochemically demonstrable somatotrophs in the adenohypophyseal pars distalis of the developing chick embryo

TitleOntogenesis of immunocytochemically demonstrable somatotrophs in the adenohypophyseal pars distalis of the developing chick embryo
Authors
Issue Date1987
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygcen
Citation
General And Comparative Endocrinology, 1987, v. 67 n. 3, p. 390-398 How to Cite?
AbstractGrowth hormone (GH)-containing cells in the hypophyseal pars distalis of the chick embryo were identified immunohistochemically using anti-chicken GH sera. GH cells are first demonstrable in Rathke's Pouch as early as Day 4.5 of incubation. By Day 9.5, when the two lobes (rostral and caudal) of the pars distalis are easily recognized, GH cells are confined exclusively to the caudal lobe. Although the number of GH cells increases gradually during embryonic development, there is a statistically significant difference between Days 10.5 and 12.5 in both the cellular density and the percentage of somatotrophs. GH cells, which contain coarse granules evenly distributed throughout the cytoplasm, varied in diameter from 9.3 μm on Day 4.5 to 11.8 μm on Day 20.5, while the nuclear diameter of these cells increased from 2.8 μm on Day 4.5 to 4.9 μm on Day 20.5. There was a statistically significant difference in the nuclear/cytoplasmic ratio between Days 4.5 and 13.5 and between Days 13.5 and 20.5 of incubation. Aspects of the regulation of growth hormone synthesis and secretion in the chick embryo are discussed. © 1987.
Persistent Identifierhttp://hdl.handle.net/10722/178459
ISSN
2015 Impact Factor: 2.667
2015 SCImago Journal Rankings: 1.245
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorThommes, RCen_US
dc.contributor.authorUmporowicz, DMen_US
dc.contributor.authorLeung, FCen_US
dc.contributor.authorWoods, JEen_US
dc.date.accessioned2012-12-19T09:47:49Z-
dc.date.available2012-12-19T09:47:49Z-
dc.date.issued1987en_US
dc.identifier.citationGeneral And Comparative Endocrinology, 1987, v. 67 n. 3, p. 390-398en_US
dc.identifier.issn0016-6480en_US
dc.identifier.urihttp://hdl.handle.net/10722/178459-
dc.description.abstractGrowth hormone (GH)-containing cells in the hypophyseal pars distalis of the chick embryo were identified immunohistochemically using anti-chicken GH sera. GH cells are first demonstrable in Rathke's Pouch as early as Day 4.5 of incubation. By Day 9.5, when the two lobes (rostral and caudal) of the pars distalis are easily recognized, GH cells are confined exclusively to the caudal lobe. Although the number of GH cells increases gradually during embryonic development, there is a statistically significant difference between Days 10.5 and 12.5 in both the cellular density and the percentage of somatotrophs. GH cells, which contain coarse granules evenly distributed throughout the cytoplasm, varied in diameter from 9.3 μm on Day 4.5 to 11.8 μm on Day 20.5, while the nuclear diameter of these cells increased from 2.8 μm on Day 4.5 to 4.9 μm on Day 20.5. There was a statistically significant difference in the nuclear/cytoplasmic ratio between Days 4.5 and 13.5 and between Days 13.5 and 20.5 of incubation. Aspects of the regulation of growth hormone synthesis and secretion in the chick embryo are discussed. © 1987.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygcenen_US
dc.relation.ispartofGeneral and Comparative Endocrinologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChick Embryoen_US
dc.subject.meshGrowth Hormone - Analysis - Immunologyen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshPituitary Gland, Anterior - Cytology - Embryologyen_US
dc.titleOntogenesis of immunocytochemically demonstrable somatotrophs in the adenohypophyseal pars distalis of the developing chick embryoen_US
dc.typeArticleen_US
dc.identifier.emailLeung, FC: fcleung@hkucc.hku.hken_US
dc.identifier.authorityLeung, FC=rp00731en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0016-6480(87)90194-8-
dc.identifier.pmid3666413-
dc.identifier.scopuseid_2-s2.0-0023409160en_US
dc.identifier.volume67en_US
dc.identifier.issue3en_US
dc.identifier.spage390en_US
dc.identifier.epage398en_US
dc.identifier.isiWOS:A1987J813400014-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridThommes, RC=6701851744en_US
dc.identifier.scopusauthoridUmporowicz, DM=6506206003en_US
dc.identifier.scopusauthoridLeung, FC=7103078633en_US
dc.identifier.scopusauthoridWoods, JE=7402318407en_US

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