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Article: Food intake and selection after peripheral tryptophan

TitleFood intake and selection after peripheral tryptophan
Authors
Issue Date1987
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/physbeh
Citation
Physiology And Behavior, 1987, v. 40 n. 2, p. 155-163 How to Cite?
AbstractTwo studies investigated the effects of peripheral (IP) administration of the dietary indispensible amino accid tryptophan, on food intake and macronutrient selection in rats adapted to a 12 hr nocturnal feeding period and a choice of 10% and 60% casein diets, In a dose-response study (35, 55, 75, 95, 115 mg/kg), the threshold dose of 75 mg/kg produced a significant reduction in total food intake (3.6 to 2.3 g, p<0.05) during the first hour of feeding. The reduction in carbohydrate intake (2.1 vs. 1.2 g, p<0.05) was greater than that for protein intake (1.6 vs. 1.1 g, p<0.05). Twelve hr total food intake was also decreased (20.9 to 19.5 g, p<0.05) and this was attributable to decreased carbohydrate intake (13.2 to 11.8 g, p<0.05).In a second study designed to determine if tryptophan's effects were mediated by the central nervous system, brain tryptophan uptake was blocked by co-injecting valine with tryptophan. The significant reduction in first hour total food intake by tryptophan was not prevented by co-injection of an equal quantity of valine (3.5 to 1.8 g, p<0.05). Again the suppression of carbohydrate intake (2.0 to 0.9 g, p<0.05) was greater than that for protein intake (1.5 to 0.9 g, p< 0.05). This dose of valine significantly reduced brain tryptophan uptake by 16% (21.3 to 17.8μg/g, p<0.05) and when administered alone did not affect first hour total food intake (3.1 vs 3.2 g), A higher dose of valine (300 mg/kg) procuced a larger decrease in brain tryptophan (15.9 to 11.7 μg/g, p<0.05), but when administered alone also significantly decreased food intake (2.9 to 0.7 g, p<0.05). Thus the site and mechanism of action for tryptophan's effects could not be elucidated. It was concluded that intraperitoneal administration of tryptophan suppresses total food intake with a small but sinificantly greater effect on carbohydrate intake compared to protein intake.
Persistent Identifierhttp://hdl.handle.net/10722/178458
ISSN
2015 Impact Factor: 2.461
2015 SCImago Journal Rankings: 1.245
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMorris, Pen_US
dc.contributor.authorLi, ETSen_US
dc.contributor.authorMacmillan, MLen_US
dc.contributor.authorAnderson, GHen_US
dc.date.accessioned2012-12-19T09:47:48Z-
dc.date.available2012-12-19T09:47:48Z-
dc.date.issued1987en_US
dc.identifier.citationPhysiology And Behavior, 1987, v. 40 n. 2, p. 155-163en_US
dc.identifier.issn0031-9384en_US
dc.identifier.urihttp://hdl.handle.net/10722/178458-
dc.description.abstractTwo studies investigated the effects of peripheral (IP) administration of the dietary indispensible amino accid tryptophan, on food intake and macronutrient selection in rats adapted to a 12 hr nocturnal feeding period and a choice of 10% and 60% casein diets, In a dose-response study (35, 55, 75, 95, 115 mg/kg), the threshold dose of 75 mg/kg produced a significant reduction in total food intake (3.6 to 2.3 g, p<0.05) during the first hour of feeding. The reduction in carbohydrate intake (2.1 vs. 1.2 g, p<0.05) was greater than that for protein intake (1.6 vs. 1.1 g, p<0.05). Twelve hr total food intake was also decreased (20.9 to 19.5 g, p<0.05) and this was attributable to decreased carbohydrate intake (13.2 to 11.8 g, p<0.05).In a second study designed to determine if tryptophan's effects were mediated by the central nervous system, brain tryptophan uptake was blocked by co-injecting valine with tryptophan. The significant reduction in first hour total food intake by tryptophan was not prevented by co-injection of an equal quantity of valine (3.5 to 1.8 g, p<0.05). Again the suppression of carbohydrate intake (2.0 to 0.9 g, p<0.05) was greater than that for protein intake (1.5 to 0.9 g, p< 0.05). This dose of valine significantly reduced brain tryptophan uptake by 16% (21.3 to 17.8μg/g, p<0.05) and when administered alone did not affect first hour total food intake (3.1 vs 3.2 g), A higher dose of valine (300 mg/kg) procuced a larger decrease in brain tryptophan (15.9 to 11.7 μg/g, p<0.05), but when administered alone also significantly decreased food intake (2.9 to 0.7 g, p<0.05). Thus the site and mechanism of action for tryptophan's effects could not be elucidated. It was concluded that intraperitoneal administration of tryptophan suppresses total food intake with a small but sinificantly greater effect on carbohydrate intake compared to protein intake.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/physbehen_US
dc.relation.ispartofPhysiology and Behavioren_US
dc.subject.meshAnimalsen_US
dc.subject.meshBrain - Metabolismen_US
dc.subject.meshDietary Carbohydrates - Metabolismen_US
dc.subject.meshDietary Proteins - Metabolismen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshFeeding Behavior - Drug Effectsen_US
dc.subject.meshFood Preferences - Drug Effectsen_US
dc.subject.meshInjections, Intraperitonealen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTryptophan - Administration & Dosage - Metabolism - Pharmacologyen_US
dc.subject.meshValine - Administration & Dosage - Pharmacologyen_US
dc.titleFood intake and selection after peripheral tryptophanen_US
dc.typeArticleen_US
dc.identifier.emailLi, ETS: etsli@hku.hken_US
dc.identifier.authorityLi, ETS=rp00737en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0031-9384(87)90201-0-
dc.identifier.pmid3628523-
dc.identifier.scopuseid_2-s2.0-0023222026en_US
dc.identifier.volume40en_US
dc.identifier.issue2en_US
dc.identifier.spage155en_US
dc.identifier.epage163en_US
dc.identifier.isiWOS:A1987H760000004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMorris, P=16033976800en_US
dc.identifier.scopusauthoridLi, ETS=14018169600en_US
dc.identifier.scopusauthoridMacMillan, ML=35802897900en_US
dc.identifier.scopusauthoridAnderson, GH=7404223441en_US

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