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Article: Interaction of human pancreatic growth hormone-releasing factor, thyrotropin-releasing hormone, and somatostatin on growth hormone release in chickens

TitleInteraction of human pancreatic growth hormone-releasing factor, thyrotropin-releasing hormone, and somatostatin on growth hormone release in chickens
Authors
Issue Date1986
PublisherSociety for Experimental Biology and Medicine. The Journal's web site is located at http://www.ebmonline.org/
Citation
Proceedings Of The Society For Experimental Biology And Medicine, 1986, v. 183 n. 3, p. 363-367 How to Cite?
AbstractThe effects of synthetic somatostatin (SRIF) on serum growth hormone (GH) concentrations stimulated by exogenous administration of synthetic thyrotropin-releasing hormone (TRH) and/or human pancreatic GH-releasing factor (hpGRF) were investigated in 4-week-old cockerels. In addition, the additive effects of TRH and hpGRF on serum GH were examined. TRH and hpGRF, when given in combination intravenously, produced an additive effect on serum GH concentration that peaked 10 min after the injection. The somatostatin did not significantly affect basal Gh concentrations when given alone, but did significantly decrease the magnitude of the Gh response to hpGRF. In contrast, SRIF did not significantly decrease the stimulatory effects of TRH on GH release. These results suggest that TRH and hpGRF are potent GH releasers in vivo and that their stimulating effects on GH release are additive, suggesting different mechanisms for their stimulation. The results obtained from the combination studies suggest that the main site of the stimulatory action of hpGRF is at the pituitary, and that SRIF significantly inhibited the rise in serum GH induced by a synthetic hpGRF, but not that induced by TRH.
Persistent Identifierhttp://hdl.handle.net/10722/178452
ISSN
2002 Impact Factor: 2.714
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTaylor, JEen_US
dc.contributor.authorBall, CAen_US
dc.contributor.authorLeung, FCen_US
dc.date.accessioned2012-12-19T09:47:46Z-
dc.date.available2012-12-19T09:47:46Z-
dc.date.issued1986en_US
dc.identifier.citationProceedings Of The Society For Experimental Biology And Medicine, 1986, v. 183 n. 3, p. 363-367en_US
dc.identifier.issn0037-9727en_US
dc.identifier.urihttp://hdl.handle.net/10722/178452-
dc.description.abstractThe effects of synthetic somatostatin (SRIF) on serum growth hormone (GH) concentrations stimulated by exogenous administration of synthetic thyrotropin-releasing hormone (TRH) and/or human pancreatic GH-releasing factor (hpGRF) were investigated in 4-week-old cockerels. In addition, the additive effects of TRH and hpGRF on serum GH were examined. TRH and hpGRF, when given in combination intravenously, produced an additive effect on serum GH concentration that peaked 10 min after the injection. The somatostatin did not significantly affect basal Gh concentrations when given alone, but did significantly decrease the magnitude of the Gh response to hpGRF. In contrast, SRIF did not significantly decrease the stimulatory effects of TRH on GH release. These results suggest that TRH and hpGRF are potent GH releasers in vivo and that their stimulating effects on GH release are additive, suggesting different mechanisms for their stimulation. The results obtained from the combination studies suggest that the main site of the stimulatory action of hpGRF is at the pituitary, and that SRIF significantly inhibited the rise in serum GH induced by a synthetic hpGRF, but not that induced by TRH.en_US
dc.languageengen_US
dc.publisherSociety for Experimental Biology and Medicine. The Journal's web site is located at http://www.ebmonline.org/en_US
dc.relation.ispartofProceedings of the Society for Experimental Biology and Medicineen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChickensen_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshGrowth Hormone - Metabolismen_US
dc.subject.meshGrowth Hormone-Releasing Hormone - Pharmacologyen_US
dc.subject.meshHumansen_US
dc.subject.meshSomatostatin - Pharmacologyen_US
dc.subject.meshThyrotropin-Releasing Hormone - Pharmacologyen_US
dc.subject.meshTime Factorsen_US
dc.titleInteraction of human pancreatic growth hormone-releasing factor, thyrotropin-releasing hormone, and somatostatin on growth hormone release in chickensen_US
dc.typeArticleen_US
dc.identifier.emailLeung, FC: fcleung@hkucc.hku.hken_US
dc.identifier.authorityLeung, FC=rp00731en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2879290-
dc.identifier.scopuseid_2-s2.0-0022889776en_US
dc.identifier.volume183en_US
dc.identifier.issue3en_US
dc.identifier.spage363en_US
dc.identifier.epage367en_US
dc.identifier.isiWOS:A1986F490300014-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTaylor, JE=7405405625en_US
dc.identifier.scopusauthoridBall, CA=7201923554en_US
dc.identifier.scopusauthoridLeung, FC=7103078633en_US

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