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- Scopus: eid_2-s2.0-0022460429
- PMID: 3463679
- WOS: WOS:A1986E129100008
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Article: Effect of zinc status on the binding of prostaglandins to ovarian membranes and intact platelets of pregnant rats
Title | Effect of zinc status on the binding of prostaglandins to ovarian membranes and intact platelets of pregnant rats |
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Authors | |
Issue Date | 1986 |
Publisher | American Society for Nutrition. The Journal's web site is located at http://jn.nutrition.org |
Citation | Journal Of Nutrition, 1986, v. 116 n. 8, p. 1448-1455 How to Cite? |
Abstract | The effects of zinc deficiency on the binding of PGF(2α) to ovarian membranes and of PGE1 to intact platelets prepared from pregnant rats were examined. On d 21 of gestation, rats fed low zinc (< 1 ppm) diets throughout pregnancy had prostaglandin receptor characteristics significantly different from those of rats fed control diets (100 ppm zinc). The number of binding sites for PGF(2α) was higher in the ovarian membranes prepared from deficient rats than in those from controls, whereas the affinity was not affected. In washed platelets from zinc-deficient rats there were fewer PGE1 binding sites but greater affinity for PGE1 than in platelets from controls. These results demonstrate that zinc status affects prostaglandin binding to membranes. The effects are not uniform with regard to different tissues and prostaglandin receptors but suggest an effect of zinc status on plasma membranes. |
Persistent Identifier | http://hdl.handle.net/10722/178443 |
ISSN | 2023 Impact Factor: 3.7 2023 SCImago Journal Rankings: 1.098 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Li, ETS | en_US |
dc.contributor.author | O'dell, BL | en_US |
dc.date.accessioned | 2012-12-19T09:47:43Z | - |
dc.date.available | 2012-12-19T09:47:43Z | - |
dc.date.issued | 1986 | en_US |
dc.identifier.citation | Journal Of Nutrition, 1986, v. 116 n. 8, p. 1448-1455 | en_US |
dc.identifier.issn | 0022-3166 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/178443 | - |
dc.description.abstract | The effects of zinc deficiency on the binding of PGF(2α) to ovarian membranes and of PGE1 to intact platelets prepared from pregnant rats were examined. On d 21 of gestation, rats fed low zinc (< 1 ppm) diets throughout pregnancy had prostaglandin receptor characteristics significantly different from those of rats fed control diets (100 ppm zinc). The number of binding sites for PGF(2α) was higher in the ovarian membranes prepared from deficient rats than in those from controls, whereas the affinity was not affected. In washed platelets from zinc-deficient rats there were fewer PGE1 binding sites but greater affinity for PGE1 than in platelets from controls. These results demonstrate that zinc status affects prostaglandin binding to membranes. The effects are not uniform with regard to different tissues and prostaglandin receptors but suggest an effect of zinc status on plasma membranes. | en_US |
dc.language | eng | en_US |
dc.publisher | American Society for Nutrition. The Journal's web site is located at http://jn.nutrition.org | en_US |
dc.relation.ispartof | Journal of Nutrition | en_US |
dc.subject.mesh | Alprostadil - Metabolism | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Blood Platelets - Metabolism | en_US |
dc.subject.mesh | Cell Membrane - Metabolism | en_US |
dc.subject.mesh | Dinoprost | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Ovary - Metabolism | en_US |
dc.subject.mesh | Pregnancy | en_US |
dc.subject.mesh | Pregnancy, Animal | en_US |
dc.subject.mesh | Prostaglandins F - Metabolism | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Inbred Strains | en_US |
dc.subject.mesh | Receptors, Prostaglandin - Metabolism | en_US |
dc.subject.mesh | Zinc - Deficiency | en_US |
dc.title | Effect of zinc status on the binding of prostaglandins to ovarian membranes and intact platelets of pregnant rats | en_US |
dc.type | Article | en_US |
dc.identifier.email | Li, ETS: etsli@hku.hk | en_US |
dc.identifier.authority | Li, ETS=rp00737 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 3463679 | - |
dc.identifier.scopus | eid_2-s2.0-0022460429 | en_US |
dc.identifier.volume | 116 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.spage | 1448 | en_US |
dc.identifier.epage | 1455 | en_US |
dc.identifier.isi | WOS:A1986E129100008 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Li, ETS=14018169600 | en_US |
dc.identifier.scopusauthorid | O'Dell, BL=7005492691 | en_US |
dc.identifier.issnl | 0022-3166 | - |