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Article: Effect of zinc status on the binding of prostaglandins to ovarian membranes and intact platelets of pregnant rats

TitleEffect of zinc status on the binding of prostaglandins to ovarian membranes and intact platelets of pregnant rats
Authors
Issue Date1986
PublisherAmerican Society for Nutrition. The Journal's web site is located at http://jn.nutrition.org
Citation
Journal Of Nutrition, 1986, v. 116 n. 8, p. 1448-1455 How to Cite?
AbstractThe effects of zinc deficiency on the binding of PGF(2α) to ovarian membranes and of PGE1 to intact platelets prepared from pregnant rats were examined. On d 21 of gestation, rats fed low zinc (< 1 ppm) diets throughout pregnancy had prostaglandin receptor characteristics significantly different from those of rats fed control diets (100 ppm zinc). The number of binding sites for PGF(2α) was higher in the ovarian membranes prepared from deficient rats than in those from controls, whereas the affinity was not affected. In washed platelets from zinc-deficient rats there were fewer PGE1 binding sites but greater affinity for PGE1 than in platelets from controls. These results demonstrate that zinc status affects prostaglandin binding to membranes. The effects are not uniform with regard to different tissues and prostaglandin receptors but suggest an effect of zinc status on plasma membranes.
Persistent Identifierhttp://hdl.handle.net/10722/178443
ISSN
2015 Impact Factor: 3.74
2015 SCImago Journal Rankings: 2.040
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, ETSen_US
dc.contributor.authorO'dell, BLen_US
dc.date.accessioned2012-12-19T09:47:43Z-
dc.date.available2012-12-19T09:47:43Z-
dc.date.issued1986en_US
dc.identifier.citationJournal Of Nutrition, 1986, v. 116 n. 8, p. 1448-1455en_US
dc.identifier.issn0022-3166en_US
dc.identifier.urihttp://hdl.handle.net/10722/178443-
dc.description.abstractThe effects of zinc deficiency on the binding of PGF(2α) to ovarian membranes and of PGE1 to intact platelets prepared from pregnant rats were examined. On d 21 of gestation, rats fed low zinc (< 1 ppm) diets throughout pregnancy had prostaglandin receptor characteristics significantly different from those of rats fed control diets (100 ppm zinc). The number of binding sites for PGF(2α) was higher in the ovarian membranes prepared from deficient rats than in those from controls, whereas the affinity was not affected. In washed platelets from zinc-deficient rats there were fewer PGE1 binding sites but greater affinity for PGE1 than in platelets from controls. These results demonstrate that zinc status affects prostaglandin binding to membranes. The effects are not uniform with regard to different tissues and prostaglandin receptors but suggest an effect of zinc status on plasma membranes.en_US
dc.languageengen_US
dc.publisherAmerican Society for Nutrition. The Journal's web site is located at http://jn.nutrition.orgen_US
dc.relation.ispartofJournal of Nutritionen_US
dc.subject.meshAlprostadil - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Platelets - Metabolismen_US
dc.subject.meshCell Membrane - Metabolismen_US
dc.subject.meshDinoprosten_US
dc.subject.meshFemaleen_US
dc.subject.meshOvary - Metabolismen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy, Animalen_US
dc.subject.meshProstaglandins F - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshReceptors, Prostaglandin - Metabolismen_US
dc.subject.meshZinc - Deficiencyen_US
dc.titleEffect of zinc status on the binding of prostaglandins to ovarian membranes and intact platelets of pregnant ratsen_US
dc.typeArticleen_US
dc.identifier.emailLi, ETS: etsli@hku.hken_US
dc.identifier.authorityLi, ETS=rp00737en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3463679-
dc.identifier.scopuseid_2-s2.0-0022460429en_US
dc.identifier.volume116en_US
dc.identifier.issue8en_US
dc.identifier.spage1448en_US
dc.identifier.epage1455en_US
dc.identifier.isiWOS:A1986E129100008-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLi, ETS=14018169600en_US
dc.identifier.scopusauthoridO'Dell, BL=7005492691en_US

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