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Article: Thyrotropin-releasing hormone stimulates body weight gain and increases thyroid hormones and growth hormone in plasma of cockerels

TitleThyrotropin-releasing hormone stimulates body weight gain and increases thyroid hormones and growth hormone in plasma of cockerels
Authors
Issue Date1984
PublisherThe Endocrine Society. The Journal's web site is located at http://endo.endojournals.org
Citation
Endocrinology, 1984, v. 115 n. 2, p. 736-740 How to Cite?
AbstractThe effect of TRH on growth in 4-week-old cockerels was examined in two separate experiments. Daily injection of TRH via the brachial vein stimulated growth in 4-week-old cockerels over 17 days of treatment in the first experiment and over 25 days in the second. In the first experiment, TRH at 1.0 μg and 10.0 μg/bird caused significant (P<0.05) increases of 12.0% and 12.4%, respectively, in growth rate, whereas in the second experiment, only the 1.0 μg/bird level of TRH caused an increase (P<0.05). In each experiment, the increase in body weight gain was not TRH dose dependent, and neither feed consumption nor feed efficiency was affected. Possible involvement of pituitary hormones in TRH-stimulated growth in cockerels was studied in a separate experiment, and the effect of TRH on plasma T3, T4, and GH were examined. TRH was given iv at 0.1, 1.0, and 10.0 μg/bird daily for 5 days, and plasma T3, T4, and GH concentrations were measured 15, 60, and 180 min postinjection by RIA on days 1, 3, and 5. The responses of T3 and T4 to TRH were greatest on day 1, were diminished by days 3 and 5, and were not dose-related. Significant, not dose-related, elevations of plasma GH concentrations were obtained at all doses of TRH. Based on these results, we suggest that TRH has the ability to promote a significant increase in body weight gain in 4-week-old cockerels, and the stimulatory effects may be mediated through GH and/or thyroid hormones.
Persistent Identifierhttp://hdl.handle.net/10722/178424
ISSN
2015 Impact Factor: 4.159
2015 SCImago Journal Rankings: 2.363
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLeung, FCen_US
dc.contributor.authorTaylor, JEen_US
dc.contributor.authorVan Iderstine, Aen_US
dc.date.accessioned2012-12-19T09:47:38Z-
dc.date.available2012-12-19T09:47:38Z-
dc.date.issued1984en_US
dc.identifier.citationEndocrinology, 1984, v. 115 n. 2, p. 736-740en_US
dc.identifier.issn0013-7227en_US
dc.identifier.urihttp://hdl.handle.net/10722/178424-
dc.description.abstractThe effect of TRH on growth in 4-week-old cockerels was examined in two separate experiments. Daily injection of TRH via the brachial vein stimulated growth in 4-week-old cockerels over 17 days of treatment in the first experiment and over 25 days in the second. In the first experiment, TRH at 1.0 μg and 10.0 μg/bird caused significant (P<0.05) increases of 12.0% and 12.4%, respectively, in growth rate, whereas in the second experiment, only the 1.0 μg/bird level of TRH caused an increase (P<0.05). In each experiment, the increase in body weight gain was not TRH dose dependent, and neither feed consumption nor feed efficiency was affected. Possible involvement of pituitary hormones in TRH-stimulated growth in cockerels was studied in a separate experiment, and the effect of TRH on plasma T3, T4, and GH were examined. TRH was given iv at 0.1, 1.0, and 10.0 μg/bird daily for 5 days, and plasma T3, T4, and GH concentrations were measured 15, 60, and 180 min postinjection by RIA on days 1, 3, and 5. The responses of T3 and T4 to TRH were greatest on day 1, were diminished by days 3 and 5, and were not dose-related. Significant, not dose-related, elevations of plasma GH concentrations were obtained at all doses of TRH. Based on these results, we suggest that TRH has the ability to promote a significant increase in body weight gain in 4-week-old cockerels, and the stimulatory effects may be mediated through GH and/or thyroid hormones.en_US
dc.languageengen_US
dc.publisherThe Endocrine Society. The Journal's web site is located at http://endo.endojournals.orgen_US
dc.relation.ispartofEndocrinologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBody Weight - Drug Effectsen_US
dc.subject.meshGrowth Hormone - Blooden_US
dc.subject.meshMaleen_US
dc.subject.meshPoultry - Blooden_US
dc.subject.meshStimulation, Chemicalen_US
dc.subject.meshThyroid Hormones - Blooden_US
dc.subject.meshThyrotropin-Releasing Hormone - Pharmacologyen_US
dc.subject.meshThyroxine - Blooden_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTriiodothyronine - Blooden_US
dc.titleThyrotropin-releasing hormone stimulates body weight gain and increases thyroid hormones and growth hormone in plasma of cockerelsen_US
dc.typeArticleen_US
dc.identifier.emailLeung, FC: fcleung@hkucc.hku.hken_US
dc.identifier.authorityLeung, FC=rp00731en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1210/endo-115-2-736-
dc.identifier.pmid6430679-
dc.identifier.scopuseid_2-s2.0-0021149104en_US
dc.identifier.volume115en_US
dc.identifier.issue2en_US
dc.identifier.spage736en_US
dc.identifier.epage740en_US
dc.identifier.isiWOS:A1984TB41600042-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLeung, FC=7103078633en_US
dc.identifier.scopusauthoridTaylor, JE=7405405625en_US
dc.identifier.scopusauthoridVan Iderstine, A=6602377005en_US

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