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Article: Inhibition of mammary tumor growth by dexamethasone in rats in the presence of high serum prolactin levels

TitleInhibition of mammary tumor growth by dexamethasone in rats in the presence of high serum prolactin levels
Authors
Issue Date1980
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Cancer Research, 1980, v. 40 n. 6, p. 1863-1866 How to Cite?
AbstractFemale Sprague-Dawley rats with established 7,12-dimethylbenz(a)anthracene-induced mammary tumors were given daily s.c. injections of 50 μg dexamethasone per rat, 0.5 mg haloperidol per kg, or both for 3 weeks. Control rats received the injection vehicles only. Mammary tumor growth was measured at weekly intervals for 21 days, and blood was collected on Days 10 and 21 of treatment for assay of prolactin. Dexamethasone produced significant regression of mammary tumors and reduced serum prolactin levels, whereas haloperidol significantly increased mammary tumor growth and greatly elevated serum prolactin levels. When dexamethasone and haloperidol were injected together, there was significant regression of mammary tumors despite markedly elevated serum prolactin levels. No significant differences in specific prolactin binding to membrane preparations of mammary tumors from these animals were observed in any treatment group. These results indicate that dexamethasone, a synthetic gluco-corticoid, can directly inhibit mammary tumor growth in the presence of elevated serum prolactin levels produced by haloperidol, and the inhibition is not due to a reduction of prolactin binding sites in the tumor tissue.
Persistent Identifierhttp://hdl.handle.net/10722/178407
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorAylsworth, CFen_US
dc.contributor.authorSylvester, PWen_US
dc.contributor.authorLeung, FCen_US
dc.contributor.authorMeites, Jen_US
dc.date.accessioned2012-12-19T09:47:33Z-
dc.date.available2012-12-19T09:47:33Z-
dc.date.issued1980en_US
dc.identifier.citationCancer Research, 1980, v. 40 n. 6, p. 1863-1866en_US
dc.identifier.issn0008-5472en_US
dc.identifier.urihttp://hdl.handle.net/10722/178407-
dc.description.abstractFemale Sprague-Dawley rats with established 7,12-dimethylbenz(a)anthracene-induced mammary tumors were given daily s.c. injections of 50 μg dexamethasone per rat, 0.5 mg haloperidol per kg, or both for 3 weeks. Control rats received the injection vehicles only. Mammary tumor growth was measured at weekly intervals for 21 days, and blood was collected on Days 10 and 21 of treatment for assay of prolactin. Dexamethasone produced significant regression of mammary tumors and reduced serum prolactin levels, whereas haloperidol significantly increased mammary tumor growth and greatly elevated serum prolactin levels. When dexamethasone and haloperidol were injected together, there was significant regression of mammary tumors despite markedly elevated serum prolactin levels. No significant differences in specific prolactin binding to membrane preparations of mammary tumors from these animals were observed in any treatment group. These results indicate that dexamethasone, a synthetic gluco-corticoid, can directly inhibit mammary tumor growth in the presence of elevated serum prolactin levels produced by haloperidol, and the inhibition is not due to a reduction of prolactin binding sites in the tumor tissue.en_US
dc.languageengen_US
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/en_US
dc.relation.ispartofCancer Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Division - Drug Effectsen_US
dc.subject.meshDexamethasone - Pharmacology - Therapeutic Useen_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHaloperidol - Antagonists & Inhibitors - Pharmacologyen_US
dc.subject.meshMammary Neoplasms, Experimental - Blood - Pathologyen_US
dc.subject.meshProlactin - Blooden_US
dc.subject.meshRatsen_US
dc.titleInhibition of mammary tumor growth by dexamethasone in rats in the presence of high serum prolactin levelsen_US
dc.typeArticleen_US
dc.identifier.emailLeung, FC: fcleung@hkucc.hku.hken_US
dc.identifier.authorityLeung, FC=rp00731en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7371016-
dc.identifier.scopuseid_2-s2.0-0018833779en_US
dc.identifier.volume40en_US
dc.identifier.issue6en_US
dc.identifier.spage1863en_US
dc.identifier.epage1866en_US
dc.identifier.isiWOS:A1980JT99100017-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridAylsworth, CF=6603910740en_US
dc.identifier.scopusauthoridSylvester, PW=7006317037en_US
dc.identifier.scopusauthoridLeung, FC=7103078633en_US
dc.identifier.scopusauthoridMeites, J=7101645729en_US

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