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- Scopus: eid_2-s2.0-0018833779
- PMID: 7371016
- WOS: WOS:A1980JT99100017
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Article: Inhibition of mammary tumor growth by dexamethasone in rats in the presence of high serum prolactin levels
Title | Inhibition of mammary tumor growth by dexamethasone in rats in the presence of high serum prolactin levels |
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Authors | |
Issue Date | 1980 |
Publisher | American Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/ |
Citation | Cancer Research, 1980, v. 40 n. 6, p. 1863-1866 How to Cite? |
Abstract | Female Sprague-Dawley rats with established 7,12-dimethylbenz(a)anthracene-induced mammary tumors were given daily s.c. injections of 50 μg dexamethasone per rat, 0.5 mg haloperidol per kg, or both for 3 weeks. Control rats received the injection vehicles only. Mammary tumor growth was measured at weekly intervals for 21 days, and blood was collected on Days 10 and 21 of treatment for assay of prolactin. Dexamethasone produced significant regression of mammary tumors and reduced serum prolactin levels, whereas haloperidol significantly increased mammary tumor growth and greatly elevated serum prolactin levels. When dexamethasone and haloperidol were injected together, there was significant regression of mammary tumors despite markedly elevated serum prolactin levels. No significant differences in specific prolactin binding to membrane preparations of mammary tumors from these animals were observed in any treatment group. These results indicate that dexamethasone, a synthetic gluco-corticoid, can directly inhibit mammary tumor growth in the presence of elevated serum prolactin levels produced by haloperidol, and the inhibition is not due to a reduction of prolactin binding sites in the tumor tissue. |
Persistent Identifier | http://hdl.handle.net/10722/178407 |
ISSN | 2023 Impact Factor: 12.5 2023 SCImago Journal Rankings: 3.468 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Aylsworth, CF | en_US |
dc.contributor.author | Sylvester, PW | en_US |
dc.contributor.author | Leung, FC | en_US |
dc.contributor.author | Meites, J | en_US |
dc.date.accessioned | 2012-12-19T09:47:33Z | - |
dc.date.available | 2012-12-19T09:47:33Z | - |
dc.date.issued | 1980 | en_US |
dc.identifier.citation | Cancer Research, 1980, v. 40 n. 6, p. 1863-1866 | en_US |
dc.identifier.issn | 0008-5472 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/178407 | - |
dc.description.abstract | Female Sprague-Dawley rats with established 7,12-dimethylbenz(a)anthracene-induced mammary tumors were given daily s.c. injections of 50 μg dexamethasone per rat, 0.5 mg haloperidol per kg, or both for 3 weeks. Control rats received the injection vehicles only. Mammary tumor growth was measured at weekly intervals for 21 days, and blood was collected on Days 10 and 21 of treatment for assay of prolactin. Dexamethasone produced significant regression of mammary tumors and reduced serum prolactin levels, whereas haloperidol significantly increased mammary tumor growth and greatly elevated serum prolactin levels. When dexamethasone and haloperidol were injected together, there was significant regression of mammary tumors despite markedly elevated serum prolactin levels. No significant differences in specific prolactin binding to membrane preparations of mammary tumors from these animals were observed in any treatment group. These results indicate that dexamethasone, a synthetic gluco-corticoid, can directly inhibit mammary tumor growth in the presence of elevated serum prolactin levels produced by haloperidol, and the inhibition is not due to a reduction of prolactin binding sites in the tumor tissue. | en_US |
dc.language | eng | en_US |
dc.publisher | American Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/ | en_US |
dc.relation.ispartof | Cancer Research | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Cell Division - Drug Effects | en_US |
dc.subject.mesh | Dexamethasone - Pharmacology - Therapeutic Use | en_US |
dc.subject.mesh | Drug Interactions | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Haloperidol - Antagonists & Inhibitors - Pharmacology | en_US |
dc.subject.mesh | Mammary Neoplasms, Experimental - Blood - Pathology | en_US |
dc.subject.mesh | Prolactin - Blood | en_US |
dc.subject.mesh | Rats | en_US |
dc.title | Inhibition of mammary tumor growth by dexamethasone in rats in the presence of high serum prolactin levels | en_US |
dc.type | Article | en_US |
dc.identifier.email | Leung, FC: fcleung@hkucc.hku.hk | en_US |
dc.identifier.authority | Leung, FC=rp00731 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 7371016 | - |
dc.identifier.scopus | eid_2-s2.0-0018833779 | en_US |
dc.identifier.volume | 40 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | 1863 | en_US |
dc.identifier.epage | 1866 | en_US |
dc.identifier.isi | WOS:A1980JT99100017 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Aylsworth, CF=6603910740 | en_US |
dc.identifier.scopusauthorid | Sylvester, PW=7006317037 | en_US |
dc.identifier.scopusauthorid | Leung, FC=7103078633 | en_US |
dc.identifier.scopusauthorid | Meites, J=7101645729 | en_US |
dc.identifier.issnl | 0008-5472 | - |