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Article: A study to verify a reported excess of chromosomal aberrations in blood lymphocytes of Namibian uranium miners

TitleA study to verify a reported excess of chromosomal aberrations in blood lymphocytes of Namibian uranium miners
Authors
Issue Date2001
Citation
Radiation Research, 2001, v. 155 n. 6, p. 809-817 How to Cite?
AbstractThis report describes a study to verify an earlier report of excess chromosomal damage in the blood lymphocytes of uranium miners. Coded blood samples from 10 miners and 10 controls were analyzed conventionally for unstable aberrations and by FISH for translocations. Conventional analysis, scoring 1000 metaphases per subject, showed no significant difference between miners and controls in the frequencies of chromosome- and chromatid-type aberrations. Investigators at two laboratories undertook FISH analyses, each scoring 4000 metaphases per subject. When the data from each laboratory were examined separately, one found slightly more translocations in the miners while the other found fewer. In neither case was the difference significant at the 95% level of confidence. Combining the data likewise showed no significant excess of damage in the miners. This applied to simple one- and two-way translocations and to cells with complex exchanges. There was no correlation between levels of translocations and total lifetime doses from occupational and/or background irradiation. A borderline significant excess of rogue cells was found in the miners. This may be a chance observation, as these rare, highly abnormal cells are considered to be unrelated to radiation exposure and are probably due to a virus. The overall conclusion is that the frequency of chromosomal damage in the miners did not exceed that in the controls. Therefore, the result of the earlier study was not confirmed. © 2001 by Radiation Research Society.
Persistent Identifierhttp://hdl.handle.net/10722/178268
ISSN
2015 Impact Factor: 3.022
2015 SCImago Journal Rankings: 1.493
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLloyd, DCen_US
dc.contributor.authorLucas, JNen_US
dc.contributor.authorEdwards, AAen_US
dc.contributor.authorDeng, Wen_US
dc.contributor.authorValente, Een_US
dc.contributor.authorHone, PAen_US
dc.contributor.authorMoquet, JEen_US
dc.date.accessioned2012-12-19T09:44:55Z-
dc.date.available2012-12-19T09:44:55Z-
dc.date.issued2001en_US
dc.identifier.citationRadiation Research, 2001, v. 155 n. 6, p. 809-817en_US
dc.identifier.issn0033-7587en_US
dc.identifier.urihttp://hdl.handle.net/10722/178268-
dc.description.abstractThis report describes a study to verify an earlier report of excess chromosomal damage in the blood lymphocytes of uranium miners. Coded blood samples from 10 miners and 10 controls were analyzed conventionally for unstable aberrations and by FISH for translocations. Conventional analysis, scoring 1000 metaphases per subject, showed no significant difference between miners and controls in the frequencies of chromosome- and chromatid-type aberrations. Investigators at two laboratories undertook FISH analyses, each scoring 4000 metaphases per subject. When the data from each laboratory were examined separately, one found slightly more translocations in the miners while the other found fewer. In neither case was the difference significant at the 95% level of confidence. Combining the data likewise showed no significant excess of damage in the miners. This applied to simple one- and two-way translocations and to cells with complex exchanges. There was no correlation between levels of translocations and total lifetime doses from occupational and/or background irradiation. A borderline significant excess of rogue cells was found in the miners. This may be a chance observation, as these rare, highly abnormal cells are considered to be unrelated to radiation exposure and are probably due to a virus. The overall conclusion is that the frequency of chromosomal damage in the miners did not exceed that in the controls. Therefore, the result of the earlier study was not confirmed. © 2001 by Radiation Research Society.en_US
dc.languageengen_US
dc.relation.ispartofRadiation Researchen_US
dc.subject.meshChromosome Aberrationsen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescenceen_US
dc.subject.meshLymphocytes - Ultrastructureen_US
dc.subject.meshMiningen_US
dc.subject.meshNamibiaen_US
dc.subject.meshOccupational Exposureen_US
dc.subject.meshUraniumen_US
dc.titleA study to verify a reported excess of chromosomal aberrations in blood lymphocytes of Namibian uranium minersen_US
dc.typeArticleen_US
dc.identifier.emailDeng, W: wdeng@hkucc.hku.hken_US
dc.identifier.authorityDeng, W=rp01640en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1667/0033-7587(2001)155[0809:ASTVAR]2.0.CO;2-
dc.identifier.pmid11352763-
dc.identifier.scopuseid_2-s2.0-0034985328en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034985328&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume155en_US
dc.identifier.issue6en_US
dc.identifier.spage809en_US
dc.identifier.epage817en_US
dc.identifier.isiWOS:000168991800007-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLloyd, DC=7402321507en_US
dc.identifier.scopusauthoridLucas, JN=7402441937en_US
dc.identifier.scopusauthoridEdwards, AA=7403547785en_US
dc.identifier.scopusauthoridDeng, W=7202223673en_US
dc.identifier.scopusauthoridValente, E=7102619317en_US
dc.identifier.scopusauthoridHone, PA=6701461695en_US
dc.identifier.scopusauthoridMoquet, JE=6603082067en_US

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