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Article: Theoretical and experimental tests of a chromosomal fingerprint for densely ionizing radiation based on F ratios calculated from stable and unstable chromosome aberrations

TitleTheoretical and experimental tests of a chromosomal fingerprint for densely ionizing radiation based on F ratios calculated from stable and unstable chromosome aberrations
Authors
Issue Date1999
Citation
Radiation Research, 1999, v. 151 n. 1, p. 85-91 How to Cite?
AbstractIn the present study, F ratios for both stable chromosome aberrations, i,e. ratios of translocations to pericentric inversions, and unstable aberrations, i.e. dicentrics and centric rings, were measured using fluorescence in situ hybridization. F ratios for stable aberrations measured after exposure to low (2.89 Gy 60Co γ rays) and high-LET (0.25 Gy 56Fe ions; 1.25 Gy 56Fe ions; 3.0 Gy 12C ions) radiation were 6.5 ± 1.5, 4.7 ± 1.6, 9.3 ± 2.5 and 10.4 ± 3.0, respectively. F ratios for unstable aberrations measured after low (2.89 Gy 60Co γ rays) and high-LET (0.25 Gy S6Fe ions; 3.0 Gy 12C ions) radiations were 6.5 ± 1.6, 6.3 ± 2.3 and 11.1 ± 3.7, respectively. No significant difference between the F ratios for low- and high-LET radiation was found. Further tests on the models for calculation of the F ratio proposed by Brenner and Sachs (Radiat. Res. 140, 134-142, 1994) showed that the F ratio may not be straightforward as a practical fingerprint for densely ionizing radiation.
Persistent Identifierhttp://hdl.handle.net/10722/178261
ISSN
2015 Impact Factor: 3.022
2015 SCImago Journal Rankings: 1.493
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLucas, JNen_US
dc.contributor.authorDeng, Wen_US
dc.contributor.authorOram, SWen_US
dc.contributor.authorHill, FSen_US
dc.contributor.authorDurante, Men_US
dc.contributor.authorGeorge, Ken_US
dc.contributor.authorWu, Hen_US
dc.contributor.authorOwens, CLen_US
dc.contributor.authorYang, Ten_US
dc.date.accessioned2012-12-19T09:44:50Z-
dc.date.available2012-12-19T09:44:50Z-
dc.date.issued1999en_US
dc.identifier.citationRadiation Research, 1999, v. 151 n. 1, p. 85-91en_US
dc.identifier.issn0033-7587en_US
dc.identifier.urihttp://hdl.handle.net/10722/178261-
dc.description.abstractIn the present study, F ratios for both stable chromosome aberrations, i,e. ratios of translocations to pericentric inversions, and unstable aberrations, i.e. dicentrics and centric rings, were measured using fluorescence in situ hybridization. F ratios for stable aberrations measured after exposure to low (2.89 Gy 60Co γ rays) and high-LET (0.25 Gy 56Fe ions; 1.25 Gy 56Fe ions; 3.0 Gy 12C ions) radiation were 6.5 ± 1.5, 4.7 ± 1.6, 9.3 ± 2.5 and 10.4 ± 3.0, respectively. F ratios for unstable aberrations measured after low (2.89 Gy 60Co γ rays) and high-LET (0.25 Gy S6Fe ions; 3.0 Gy 12C ions) radiations were 6.5 ± 1.6, 6.3 ± 2.3 and 11.1 ± 3.7, respectively. No significant difference between the F ratios for low- and high-LET radiation was found. Further tests on the models for calculation of the F ratio proposed by Brenner and Sachs (Radiat. Res. 140, 134-142, 1994) showed that the F ratio may not be straightforward as a practical fingerprint for densely ionizing radiation.en_US
dc.languageengen_US
dc.relation.ispartofRadiation Researchen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshChromosome Inversionen_US
dc.subject.meshChromosomes, Human - Radiation Effectsen_US
dc.subject.meshDna Fingerprintingen_US
dc.subject.meshDose-Response Relationship, Radiationen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescenceen_US
dc.subject.meshLinear Energy Transferen_US
dc.subject.meshLymphocytes - Radiation Effects - Ultrastructureen_US
dc.subject.meshTranslocation, Geneticen_US
dc.titleTheoretical and experimental tests of a chromosomal fingerprint for densely ionizing radiation based on F ratios calculated from stable and unstable chromosome aberrationsen_US
dc.typeArticleen_US
dc.identifier.emailDeng, W: wdeng@hkucc.hku.hken_US
dc.identifier.authorityDeng, W=rp01640en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.2307/3579752en_US
dc.identifier.pmid9973089-
dc.identifier.scopuseid_2-s2.0-0032929897en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032929897&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume151en_US
dc.identifier.issue1en_US
dc.identifier.spage85en_US
dc.identifier.epage91en_US
dc.identifier.isiWOS:000077910400011-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLucas, JN=7402441937en_US
dc.identifier.scopusauthoridDeng, W=7202223673en_US
dc.identifier.scopusauthoridOram, SW=36889376000en_US
dc.identifier.scopusauthoridHill, FS=35479640200en_US
dc.identifier.scopusauthoridDurante, M=7004828918en_US
dc.identifier.scopusauthoridGeorge, K=10639000600en_US
dc.identifier.scopusauthoridWu, H=7405584225en_US
dc.identifier.scopusauthoridOwens, CL=7102511373en_US
dc.identifier.scopusauthoridYang, T=36038666400en_US

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