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Article: Alpha coefficient of dose-response for chromosome translocations measured by FISH in human lymphocytes exposed to chronic 60Co gamma rays at body temperature

TitleAlpha coefficient of dose-response for chromosome translocations measured by FISH in human lymphocytes exposed to chronic 60Co gamma rays at body temperature
Authors
Issue Date1999
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/09553002.asp
Citation
International Journal Of Radiation Biology, 1999, v. 75 n. 4, p. 435-439 How to Cite?
AbstractPurpose: To measure the alpha coefficient, the initial slope of the translocation dose-response curve, for 60Co γ-rays in human lymphocytes. Materials and methods: Human lymphocytes were exposed to 0, 0.32, 0.62 and 0.92 Gy of chronic 60Co γ-rays under conditions that reduce the metabolic stress to the cells. Chromosome translocation frequencies were measured using fluorescence in situ hybridization with a whole-chromosome probe cocktail specific for chromosomes 1, 2, 4 (orange) and 3, 5, 6 (green). Results: A total of 72 383 metaphases were analysed (33 429 in exposed cells) in two individuals. The shape of the dose-response curves for translocations was linear, and alpha coefficient was measured as 0.024 ± 0.002 translocations per cell per Gy for the combined data for two 24 year old male donors. Conclusion: The alpha coefficients measured after chronic exposure were in good agreement with that reported in the literature for acute, low-dose exposure of human lymphocytes to 60Co γ-rays.
Persistent Identifierhttp://hdl.handle.net/10722/178260
ISSN
2015 Impact Factor: 1.779
2015 SCImago Journal Rankings: 0.734
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHsieh, WAen_US
dc.contributor.authorDeng, Wen_US
dc.contributor.authorChang, WPen_US
dc.contributor.authorGalvan, Nen_US
dc.contributor.authorOwens, CLen_US
dc.contributor.authorMorrison, DPen_US
dc.contributor.authorGale, KLen_US
dc.contributor.authorLucas, JNen_US
dc.date.accessioned2012-12-19T09:44:49Z-
dc.date.available2012-12-19T09:44:49Z-
dc.date.issued1999en_US
dc.identifier.citationInternational Journal Of Radiation Biology, 1999, v. 75 n. 4, p. 435-439en_US
dc.identifier.issn0955-3002en_US
dc.identifier.urihttp://hdl.handle.net/10722/178260-
dc.description.abstractPurpose: To measure the alpha coefficient, the initial slope of the translocation dose-response curve, for 60Co γ-rays in human lymphocytes. Materials and methods: Human lymphocytes were exposed to 0, 0.32, 0.62 and 0.92 Gy of chronic 60Co γ-rays under conditions that reduce the metabolic stress to the cells. Chromosome translocation frequencies were measured using fluorescence in situ hybridization with a whole-chromosome probe cocktail specific for chromosomes 1, 2, 4 (orange) and 3, 5, 6 (green). Results: A total of 72 383 metaphases were analysed (33 429 in exposed cells) in two individuals. The shape of the dose-response curves for translocations was linear, and alpha coefficient was measured as 0.024 ± 0.002 translocations per cell per Gy for the combined data for two 24 year old male donors. Conclusion: The alpha coefficients measured after chronic exposure were in good agreement with that reported in the literature for acute, low-dose exposure of human lymphocytes to 60Co γ-rays.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/09553002.aspen_US
dc.relation.ispartofInternational Journal of Radiation Biologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAlpha Particlesen_US
dc.subject.meshBody Temperature - Radiation Effectsen_US
dc.subject.meshCobalt Radioisotopesen_US
dc.subject.meshDose-Response Relationship, Radiationen_US
dc.subject.meshGamma Raysen_US
dc.subject.meshHumansen_US
dc.subject.meshLymphocytes - Radiation Effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshTranslocation, Genetic - Radiation Effectsen_US
dc.titleAlpha coefficient of dose-response for chromosome translocations measured by FISH in human lymphocytes exposed to chronic 60Co gamma rays at body temperatureen_US
dc.typeArticleen_US
dc.identifier.emailDeng, W: wdeng@hkucc.hku.hken_US
dc.identifier.authorityDeng, W=rp01640en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1080/095530099140357-
dc.identifier.pmid10331848-
dc.identifier.scopuseid_2-s2.0-0032901852en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032901852&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume75en_US
dc.identifier.issue4en_US
dc.identifier.spage435en_US
dc.identifier.epage439en_US
dc.identifier.isiWOS:000079745700005-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridHsieh, WA=7203083198en_US
dc.identifier.scopusauthoridDeng, W=7202223673en_US
dc.identifier.scopusauthoridChang, WP=7404564878en_US
dc.identifier.scopusauthoridGalvan, N=55293870700en_US
dc.identifier.scopusauthoridOwens, CL=7102511373en_US
dc.identifier.scopusauthoridMorrison, DP=7402118438en_US
dc.identifier.scopusauthoridGale, KL=35510051700en_US
dc.identifier.scopusauthoridLucas, JN=7402441937en_US

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