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Article: Background ionizing radiation plays a minor role in the production of chromosome translocations in a control population

TitleBackground ionizing radiation plays a minor role in the production of chromosome translocations in a control population
Authors
Issue Date1999
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/09553002.asp
Citation
International Journal Of Radiation Biology, 1999, v. 75 n. 7, p. 819-827 How to Cite?
AbstractPurpose: To obtain a relationship between background chromosome translocation frequency and age with translocation frequency measured to a high statistical precision, and to identify the role of background ionizing radiation in the production of chromosome translocations in a control population. Materials and methods: Lymphocytes from 35 healthy control individuals (15 females and 20 males) were scored, using fluorescence in situ hybridization, for the presence of chromosomal translocations. Translocation frequencies were measured to a high statistical precision (s.d. 25% or less for each individual). These control subjects were of varying ages, ranging from 0 (cord blood) to 98 years. Results: In a total of 521,492 metaphases (203,754 genome equivalent cells) scored, an average of 5,822 genome equivalent cells per individual, 764 translocations were observed in the 35 individuals. The translocation frequencies ranged from 0 (for cord blood) to 0.0167 (for a 98 year old) translocations per cell. The average age and translocation frequency was 50 years and 0.004 translocations per cell, respectively. The best fit of the relationship between translocations and age was: Y=7 x 10 -4+6.9 x 10 -6 A+1.35 x 10 -6 A 2, which does not obey the linear relationship expected from chronic background radiation alone. The curvilinear relationship observed clearly shows that other endogenous and exogenous clastogens or clastogenic events, in addition to radiation, serve to generate chromosome translocations in control populations. Conclusion: The background translocation frequency in control individuals follows a curvilinear relationship with age. No significant variation was observed between individuals of the same age. Clastogenic processes of normal aging and physiological factors in additional to ionizing radiation play a major role in the production of chromosome translocations in a control population. Background radiation, however, appears to play a minor role in chromosome translocation production in control individuals living near sea level.
Persistent Identifierhttp://hdl.handle.net/10722/178258
ISSN
2015 Impact Factor: 1.779
2015 SCImago Journal Rankings: 0.734
References

 

DC FieldValueLanguage
dc.contributor.authorLucas, JNen_US
dc.contributor.authorDeng, Wen_US
dc.contributor.authorMoore, Den_US
dc.contributor.authorHill, Fen_US
dc.contributor.authorWade, Men_US
dc.contributor.authorLewis, Aen_US
dc.contributor.authorSailes, Fen_US
dc.contributor.authorKramer, Cen_US
dc.contributor.authorHsieh, Aen_US
dc.contributor.authorGalvan, Nen_US
dc.date.accessioned2012-12-19T09:44:48Z-
dc.date.available2012-12-19T09:44:48Z-
dc.date.issued1999en_US
dc.identifier.citationInternational Journal Of Radiation Biology, 1999, v. 75 n. 7, p. 819-827en_US
dc.identifier.issn0955-3002en_US
dc.identifier.urihttp://hdl.handle.net/10722/178258-
dc.description.abstractPurpose: To obtain a relationship between background chromosome translocation frequency and age with translocation frequency measured to a high statistical precision, and to identify the role of background ionizing radiation in the production of chromosome translocations in a control population. Materials and methods: Lymphocytes from 35 healthy control individuals (15 females and 20 males) were scored, using fluorescence in situ hybridization, for the presence of chromosomal translocations. Translocation frequencies were measured to a high statistical precision (s.d. 25% or less for each individual). These control subjects were of varying ages, ranging from 0 (cord blood) to 98 years. Results: In a total of 521,492 metaphases (203,754 genome equivalent cells) scored, an average of 5,822 genome equivalent cells per individual, 764 translocations were observed in the 35 individuals. The translocation frequencies ranged from 0 (for cord blood) to 0.0167 (for a 98 year old) translocations per cell. The average age and translocation frequency was 50 years and 0.004 translocations per cell, respectively. The best fit of the relationship between translocations and age was: Y=7 x 10 -4+6.9 x 10 -6 A+1.35 x 10 -6 A 2, which does not obey the linear relationship expected from chronic background radiation alone. The curvilinear relationship observed clearly shows that other endogenous and exogenous clastogens or clastogenic events, in addition to radiation, serve to generate chromosome translocations in control populations. Conclusion: The background translocation frequency in control individuals follows a curvilinear relationship with age. No significant variation was observed between individuals of the same age. Clastogenic processes of normal aging and physiological factors in additional to ionizing radiation play a major role in the production of chromosome translocations in a control population. Background radiation, however, appears to play a minor role in chromosome translocation production in control individuals living near sea level.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/09553002.aspen_US
dc.relation.ispartofInternational Journal of Radiation Biologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAging - Geneticsen_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshBackground Radiation - Adverse Effectsen_US
dc.subject.meshChromosome Aberrationsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRadiobiologyen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshTranslocation, Genetic - Radiation Effectsen_US
dc.titleBackground ionizing radiation plays a minor role in the production of chromosome translocations in a control populationen_US
dc.typeArticleen_US
dc.identifier.emailDeng, W: wdeng@hkucc.hku.hken_US
dc.identifier.authorityDeng, W=rp01640en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1080/095530099139872en_US
dc.identifier.pmid10489893-
dc.identifier.scopuseid_2-s2.0-0032783374en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032783374&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume75en_US
dc.identifier.issue7en_US
dc.identifier.spage819en_US
dc.identifier.epage827en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLucas, JN=7402441937en_US
dc.identifier.scopusauthoridDeng, W=7202223673en_US
dc.identifier.scopusauthoridMoore, D=7404567244en_US
dc.identifier.scopusauthoridHill, F=35479640200en_US
dc.identifier.scopusauthoridWade, M=7201453339en_US
dc.identifier.scopusauthoridLewis, A=55452347600en_US
dc.identifier.scopusauthoridSailes, F=36060179300en_US
dc.identifier.scopusauthoridKramer, C=7201349672en_US
dc.identifier.scopusauthoridHsieh, A=7006262269en_US
dc.identifier.scopusauthoridGalvan, N=55293870700en_US

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