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Article: Vascularized peripheral nerve trunk autografted in the spinal cord: a new experimental model in adult rats.

TitleVascularized peripheral nerve trunk autografted in the spinal cord: a new experimental model in adult rats.
Authors
Issue Date2001
Citation
Chinese Journal Of Traumatology = Chung-Hua ChUang Shang Tsa Chih / Chinese Medical Association, 2001, v. 4 n. 4, p. 208-213 How to Cite?
AbstractOBJECTIVE: To investigate the effect of vascularized peripheral nerve trunk autografted in spinal cord. METHODS: With modern microsurgical technique, vascularized peripheral median and ulnar nerve trunk autografted in the upper thoracic region of the spinal cord were established in 20 female adult rats. The origin and the termination of axons in the graft were studied by retrograde neuronal labeling with horseradish peroxidase (HRP). Cord, nerve grafts and some normal median an d ul nar nerves in the right upper limb were removed and sectioned for Bielschowsky's silver stain and haematoxylin and eosin (H&E) stain. Light and electron microscopic examination and electrophysiological examination were applied. RESULTS: The grafts were innervated by many new fibers. Studies with HRP indicated that new axons in graft were originated from intrinsic cent ral nervous system (CNS) neurons with their cell bodies from brain stem to s acral segments of spinal cord. Other axons arose from dorsal root ganglia at the level of graft and at least 19 distal segments to them. Together with electron microscopy, electrophysiological examination, silver and H&E stain, the results demonstrated that vascularized peripheral nerve trunk grafted in spinal cord attracted many neurons to grow into the nerve grafts. CONCLUSIONS: The findings implicate that CNS is able to regenerate much better in vascularized nerve autografted in spinal cord.
Persistent Identifierhttp://hdl.handle.net/10722/178220
ISSN
2015 SCImago Journal Rankings: 0.183

 

DC FieldValueLanguage
dc.contributor.authorWang, Aen_US
dc.contributor.authorChow, SPen_US
dc.date.accessioned2012-12-19T09:43:29Z-
dc.date.available2012-12-19T09:43:29Z-
dc.date.issued2001en_US
dc.identifier.citationChinese Journal Of Traumatology = Chung-Hua ChUang Shang Tsa Chih / Chinese Medical Association, 2001, v. 4 n. 4, p. 208-213en_US
dc.identifier.issn1008-1275en_US
dc.identifier.urihttp://hdl.handle.net/10722/178220-
dc.description.abstractOBJECTIVE: To investigate the effect of vascularized peripheral nerve trunk autografted in spinal cord. METHODS: With modern microsurgical technique, vascularized peripheral median and ulnar nerve trunk autografted in the upper thoracic region of the spinal cord were established in 20 female adult rats. The origin and the termination of axons in the graft were studied by retrograde neuronal labeling with horseradish peroxidase (HRP). Cord, nerve grafts and some normal median an d ul nar nerves in the right upper limb were removed and sectioned for Bielschowsky's silver stain and haematoxylin and eosin (H&E) stain. Light and electron microscopic examination and electrophysiological examination were applied. RESULTS: The grafts were innervated by many new fibers. Studies with HRP indicated that new axons in graft were originated from intrinsic cent ral nervous system (CNS) neurons with their cell bodies from brain stem to s acral segments of spinal cord. Other axons arose from dorsal root ganglia at the level of graft and at least 19 distal segments to them. Together with electron microscopy, electrophysiological examination, silver and H&E stain, the results demonstrated that vascularized peripheral nerve trunk grafted in spinal cord attracted many neurons to grow into the nerve grafts. CONCLUSIONS: The findings implicate that CNS is able to regenerate much better in vascularized nerve autografted in spinal cord.en_US
dc.languageengen_US
dc.relation.ispartofChinese journal of traumatology = Chung-hua ch"uang shang tsa chih / Chinese Medical Associationen_US
dc.subject.meshAnimalsen_US
dc.subject.meshFemaleen_US
dc.subject.meshMicrosurgeryen_US
dc.subject.meshModels, Animalen_US
dc.subject.meshNerve Regenerationen_US
dc.subject.meshPeripheral Nerves - Transplantationen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSpinal Cord Injuries - Physiopathology - Surgeryen_US
dc.titleVascularized peripheral nerve trunk autografted in the spinal cord: a new experimental model in adult rats.en_US
dc.typeArticleen_US
dc.identifier.emailChow, SP: spchow@hku.hken_US
dc.identifier.authorityChow, SP=rp00064en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid11835734-
dc.identifier.scopuseid_2-s2.0-0035522607en_US
dc.identifier.volume4en_US
dc.identifier.issue4en_US
dc.identifier.spage208en_US
dc.identifier.epage213en_US
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridWang, A=8381220000en_US
dc.identifier.scopusauthoridChow, SP=7201828376en_US

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