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Article: Reinnervation of denervated skeletal muscles by grafted dorsal root ganglion

TitleReinnervation of denervated skeletal muscles by grafted dorsal root ganglion
Authors
Issue Date1992
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexnr
Citation
Experimental Neurology, 1992, v. 118 n. 3, p. 291-301 How to Cite?
AbstractWe examined whether or not the cervical dorsal root ganglion (DRG) of the rat, when isografted and connected to the distal stump of the severed common peroneal nerve, could survive, project axons to the denervated leg muscles, and exert beneficial influences to delay the degeneration of the denervated muscles. Rats in which the muscles were similarly denervated but no DRG was grafted served as the control. After a postoperative period of 72 to 286 days, histological study showed that nerve cells at the superficial part of the grafted DRG survived. Indirect electrical stimulation via the distal stump of the common peroneal nerve produced no contraction of the muscles, indicating that no functional neuromuscular contacts had been reestablished. Direct stimulation of the denervated muscles did elicit contraction, and the isometric twitch and tetanic tensions were significantly much higher in the experimental rats with a grafted DRG than in the control rats. Cholinesterase-silver staining indicated the presence of axons in the denervated muscles, but the axons did not terminate on endplates. Compared with the control muscles, the experimental muscles had significantly more axons, and had atrophied less as indicated by muscle wet weight and histological appearance. These results indicate that the sensory axons can delay the weakening and atrophy of muscles after denervation. We suggest that the sensory axons may exert certain trophic influence on the denervated muscle fibers, though the actual mechanism is unknown.
Persistent Identifierhttp://hdl.handle.net/10722/178192
ISSN
2015 Impact Factor: 4.657
2015 SCImago Journal Rankings: 2.427
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorOchi, Men_US
dc.contributor.authorKwong, WHen_US
dc.contributor.authorKimori, Ken_US
dc.contributor.authorChow, SPen_US
dc.contributor.authorIkuta, Yen_US
dc.date.accessioned2012-12-19T09:43:21Z-
dc.date.available2012-12-19T09:43:21Z-
dc.date.issued1992en_US
dc.identifier.citationExperimental Neurology, 1992, v. 118 n. 3, p. 291-301en_US
dc.identifier.issn0014-4886en_US
dc.identifier.urihttp://hdl.handle.net/10722/178192-
dc.description.abstractWe examined whether or not the cervical dorsal root ganglion (DRG) of the rat, when isografted and connected to the distal stump of the severed common peroneal nerve, could survive, project axons to the denervated leg muscles, and exert beneficial influences to delay the degeneration of the denervated muscles. Rats in which the muscles were similarly denervated but no DRG was grafted served as the control. After a postoperative period of 72 to 286 days, histological study showed that nerve cells at the superficial part of the grafted DRG survived. Indirect electrical stimulation via the distal stump of the common peroneal nerve produced no contraction of the muscles, indicating that no functional neuromuscular contacts had been reestablished. Direct stimulation of the denervated muscles did elicit contraction, and the isometric twitch and tetanic tensions were significantly much higher in the experimental rats with a grafted DRG than in the control rats. Cholinesterase-silver staining indicated the presence of axons in the denervated muscles, but the axons did not terminate on endplates. Compared with the control muscles, the experimental muscles had significantly more axons, and had atrophied less as indicated by muscle wet weight and histological appearance. These results indicate that the sensory axons can delay the weakening and atrophy of muscles after denervation. We suggest that the sensory axons may exert certain trophic influence on the denervated muscle fibers, though the actual mechanism is unknown.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexnren_US
dc.relation.ispartofExperimental Neurologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDenervationen_US
dc.subject.meshGanglia, Spinal - Pathologyen_US
dc.subject.meshMuscle Contractionen_US
dc.subject.meshMuscles - Innervation - Physiopathology - Surgeryen_US
dc.subject.meshNerve Regenerationen_US
dc.subject.meshNerve Tissue - Transplantationen_US
dc.subject.meshOrgan Sizeen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Wkyen_US
dc.titleReinnervation of denervated skeletal muscles by grafted dorsal root ganglionen_US
dc.typeArticleen_US
dc.identifier.emailChow, SP: spchow@hku.hken_US
dc.identifier.authorityChow, SP=rp00064en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0014-4886(92)90186-Ten_US
dc.identifier.pmid1306487-
dc.identifier.scopuseid_2-s2.0-0027062982en_US
dc.identifier.volume118en_US
dc.identifier.issue3en_US
dc.identifier.spage291en_US
dc.identifier.epage301en_US
dc.identifier.isiWOS:A1992KF58200006-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridOchi, M=7201374971en_US
dc.identifier.scopusauthoridKwong, WH=35587275800en_US
dc.identifier.scopusauthoridKimori, K=6603288198en_US
dc.identifier.scopusauthoridChow, SP=7201828376en_US
dc.identifier.scopusauthoridIkuta, Y=16072878200en_US

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