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Article: Antagonism of the hypnotic effect of midazolam in children: A randomized, double-blind study of placebo and flumazenil administered after midazolam-induced anaesthesia

TitleAntagonism of the hypnotic effect of midazolam in children: A randomized, double-blind study of placebo and flumazenil administered after midazolam-induced anaesthesia
Authors
Issue Date1991
PublisherOxford University Press. The Journal's web site is located at http://bja.oxfordjournals.org/
Citation
British Journal Of Anaesthesia, 1991, v. 66 n. 6, p. 660-666 How to Cite?
AbstractIn a randomized, double-blind study, we administered placebo and flumazenil to 40 healthy Chinese boys, aged 3-12 yr, undergoing circumcision. The children received midazolam 0.5 mg kg -1 orally for premedication and 0.5 mg kg -1 i.v. during induction. After operation the patients were given 0.1 ml kg -1 of a blinded solution followed by 0.05 ml kg -1 min -1 until either they awoke or the 10-ml ampoule of solution was empty. Efficacy of antagonism of midazolam was assessed by times to eye opening and self identification, modified Steward coma scale, a post-box toy completion-time ratio and qualitatively by an independent observer. The difference between flumazenil and placebo was both clinically and statistically different in the first 2 h. Children receiving flumazenil awoke approximately four times faster and identified themselves nearly three times sooner; 65% of this group could complete the post-box toy at 10 min, compared with none of the placebo group. There were no cases of resedation, but one child did not awake for 80 min after i.v. administration of flumazenil 1.0 mg. The mean total dose of flumazenil administered was 0.024 (SD 0.019) mg kg -1. Flumazenil rapidly antagonized midazolam-induced hypnosis in children and was associated with minimal change in cardiorespiratory variables.
Persistent Identifierhttp://hdl.handle.net/10722/178095
ISSN
2015 Impact Factor: 5.616
2015 SCImago Journal Rankings: 2.314
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJones, RDMen_US
dc.contributor.authorLawson, ADen_US
dc.contributor.authorAndrew, LJen_US
dc.contributor.authorGunawardene, WMSen_US
dc.contributor.authorBaconShone, Jen_US
dc.date.accessioned2012-12-19T09:42:28Z-
dc.date.available2012-12-19T09:42:28Z-
dc.date.issued1991en_US
dc.identifier.citationBritish Journal Of Anaesthesia, 1991, v. 66 n. 6, p. 660-666en_US
dc.identifier.issn0007-0912en_US
dc.identifier.urihttp://hdl.handle.net/10722/178095-
dc.description.abstractIn a randomized, double-blind study, we administered placebo and flumazenil to 40 healthy Chinese boys, aged 3-12 yr, undergoing circumcision. The children received midazolam 0.5 mg kg -1 orally for premedication and 0.5 mg kg -1 i.v. during induction. After operation the patients were given 0.1 ml kg -1 of a blinded solution followed by 0.05 ml kg -1 min -1 until either they awoke or the 10-ml ampoule of solution was empty. Efficacy of antagonism of midazolam was assessed by times to eye opening and self identification, modified Steward coma scale, a post-box toy completion-time ratio and qualitatively by an independent observer. The difference between flumazenil and placebo was both clinically and statistically different in the first 2 h. Children receiving flumazenil awoke approximately four times faster and identified themselves nearly three times sooner; 65% of this group could complete the post-box toy at 10 min, compared with none of the placebo group. There were no cases of resedation, but one child did not awake for 80 min after i.v. administration of flumazenil 1.0 mg. The mean total dose of flumazenil administered was 0.024 (SD 0.019) mg kg -1. Flumazenil rapidly antagonized midazolam-induced hypnosis in children and was associated with minimal change in cardiorespiratory variables.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://bja.oxfordjournals.org/en_US
dc.relation.ispartofBritish Journal of Anaesthesiaen_US
dc.subject.meshAnesthesia Recovery Perioden_US
dc.subject.meshAnesthesia, Generalen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCircumcision, Maleen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshFlumazenil - Pharmacologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMidazolam - Antagonists & Inhibitorsen_US
dc.subject.meshPhimosis - Surgeryen_US
dc.subject.meshPlacebosen_US
dc.subject.meshPsychomotor Performance - Drug Effectsen_US
dc.titleAntagonism of the hypnotic effect of midazolam in children: A randomized, double-blind study of placebo and flumazenil administered after midazolam-induced anaesthesiaen_US
dc.typeArticleen_US
dc.identifier.emailBaconShone, J: johnbs@hku.hken_US
dc.identifier.authorityBaconShone, J=rp00056en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/bja/66.6.660-
dc.identifier.pmid2064881-
dc.identifier.scopuseid_2-s2.0-0025861849en_US
dc.identifier.volume66en_US
dc.identifier.issue6en_US
dc.identifier.spage660en_US
dc.identifier.epage666en_US
dc.identifier.isiWOS:A1991FR89000007-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridJones, RDM=7501542949en_US
dc.identifier.scopusauthoridLawson, AD=16307418000en_US
dc.identifier.scopusauthoridAndrew, LJ=7005545537en_US
dc.identifier.scopusauthoridGunawardene, WMS=6602656509en_US
dc.identifier.scopusauthoridBaconShone, J=6602137416en_US

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