Computer fluid dynamics study of intracerebral aneurysms after flow-diverter treatment

Abstract

BACKGROUND: The introduction of flow-diverters such as the Pipeline embolization device in recent years has widened the scope of endovascular therapeutic options of intracerebral aneurysms, particularly in those with difficult morphology such as wide-necked aneurysm. It limits blood flow into the aneurysmal sac thus facilitating obliteration, and allows preservation of flow into nearby vascular side-branches. The initial results are promising with obliteration rates in the range of 80-90%. However, the intra-aneurysmal and side-branches fluid dynamics before and after stent placement is not well understood. The geometrical risk factors for treatment failure and complications are also unclear. We aim to study the fluid dynamics related to the use of such flow-diverters using computational and actual models. METHOD: Using computational and 3-dimentional manufacturing techniques we created idealized and actual models of intracerebral aneurysms based on clinical data. Various parameters of flow dynamics are measured by USG and computational calculation prior and after Pipeline embolization device placement. RESULTS: We present data on the flow dynamics difference after flow-diverters treatment in intra-cerebral aneurysm models. Differences in the number of stents deployed, the influence of blood pressure, aspect ratio and other variables will be analyzed.