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Article: Does prohibitin expression regulate sperm mitochondrial membrane potential, sperm motility, and male fertility?

TitleDoes prohibitin expression regulate sperm mitochondrial membrane potential, sperm motility, and male fertility?
Authors
Issue Date2012
PublisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/ars
Citation
Antioxidants & Redox Signaling, 2012, v. 17 n. 3, p. 513-519 How to Cite?
AbstractProhibitin (PHB) is a highly conserved major sperm mitochondrial membrane protein whose absence in somatic cells is associated with mitochondrial membrane depolarization and increased generation of reactive oxygen species (ROS). Our recent findings suggest that high levels of oxidants in human semen may contribute to male infertility and that sperm motility could be the earliest and most sensitive indicator of oxidative damage. Based on PHB's roles in mitochondrial sub-compartmentalization and respiratory chain assembly, we examine sperm PHB expression and mitochondrial membrane potential (MITO) in infertile men with poor sperm motility (asthenospermia, A) and/or low sperm concentrations (oligoasthenospermia, OA). Here, we demonstrate that MITO is significantly lower in sperm from A and OA subjects than in normospermic (N) subjects; the decrease is more severe for OA than for A subjects. PHB expression is also significantly lower in sperm from A and OA subjects. Significantly positive correlations are found among PHB expression, MITO, and sperm motility in normospermic, asthenospermic, and oligoasthenospermic subjects. Collectively, our observations lead to the hypothesis that PHB expression is an indicator of sperm quality in infertile men, and that it regulates sperm motility via an alteration in MITO and increased ROS levels. © Copyright 2012, Mary Ann Liebert, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/177335
ISSN
2015 Impact Factor: 7.093
2015 SCImago Journal Rankings: 3.134
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, MJen_US
dc.contributor.authorOu, JXen_US
dc.contributor.authorChen, GWen_US
dc.contributor.authorWu, JPen_US
dc.contributor.authorShi, HJen_US
dc.contributor.authorO, WSen_US
dc.contributor.authorMartin-DeLeon, PAen_US
dc.contributor.authorChen, Hen_US
dc.date.accessioned2012-12-18T05:02:05Z-
dc.date.available2012-12-18T05:02:05Z-
dc.date.issued2012en_US
dc.identifier.citationAntioxidants & Redox Signaling, 2012, v. 17 n. 3, p. 513-519en_US
dc.identifier.issn1523-0864-
dc.identifier.urihttp://hdl.handle.net/10722/177335-
dc.description.abstractProhibitin (PHB) is a highly conserved major sperm mitochondrial membrane protein whose absence in somatic cells is associated with mitochondrial membrane depolarization and increased generation of reactive oxygen species (ROS). Our recent findings suggest that high levels of oxidants in human semen may contribute to male infertility and that sperm motility could be the earliest and most sensitive indicator of oxidative damage. Based on PHB's roles in mitochondrial sub-compartmentalization and respiratory chain assembly, we examine sperm PHB expression and mitochondrial membrane potential (MITO) in infertile men with poor sperm motility (asthenospermia, A) and/or low sperm concentrations (oligoasthenospermia, OA). Here, we demonstrate that MITO is significantly lower in sperm from A and OA subjects than in normospermic (N) subjects; the decrease is more severe for OA than for A subjects. PHB expression is also significantly lower in sperm from A and OA subjects. Significantly positive correlations are found among PHB expression, MITO, and sperm motility in normospermic, asthenospermic, and oligoasthenospermic subjects. Collectively, our observations lead to the hypothesis that PHB expression is an indicator of sperm quality in infertile men, and that it regulates sperm motility via an alteration in MITO and increased ROS levels. © Copyright 2012, Mary Ann Liebert, Inc.-
dc.languageengen_US
dc.publisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/ars-
dc.relation.ispartofAntioxidants & Redox Signalingen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsThis is a copy of an article published in the [Antioxidants & Redox Signaling] © [2012] [copyright Mary Ann Liebert, Inc.]; [Antioxidants & Redox Signaling] is available online at: http://www.liebertonline.com.-
dc.subject.meshMembrane Potential, Mitochondrial-
dc.subject.meshMitochondria - metabolism-
dc.subject.meshReactive Oxygen Species - metabolism-
dc.subject.meshRepressor Proteins - metabolism-
dc.subject.meshSperm Motility-
dc.subject.meshInfertility, Male - metabolism-
dc.subject.meshStatistics, Nonparametric-
dc.subject.meshHumans-
dc.subject.meshAdult-
dc.subject.meshMale-
dc.titleDoes prohibitin expression regulate sperm mitochondrial membrane potential, sperm motility, and male fertility?en_US
dc.typeArticleen_US
dc.identifier.emailO, WS: owaisum@hkucc.hku.hken_US
dc.identifier.authorityO, WS=rp00315en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1089/ars.2012.4514-
dc.identifier.pmid22324369-
dc.identifier.scopuseid_2-s2.0-84862196342-
dc.identifier.hkuros204334en_US
dc.identifier.volume17en_US
dc.identifier.issue3-
dc.identifier.spage513en_US
dc.identifier.epage519en_US
dc.identifier.eissn1557-7716-
dc.identifier.isiWOS:000305291900010-
dc.publisher.placeUnited States-

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