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Article: In vivo and ex vivo effects of propofol on myocardial performance in rats with obstructive jaundice

TitleIn vivo and ex vivo effects of propofol on myocardial performance in rats with obstructive jaundice
Authors
Issue Date2011
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcgastroenterol/
Citation
BMC Gastroenterology, 2011, v. 11, article no. 144 How to Cite?
AbstractBACKGROUND: Responsiveness of the 'jaundiced heart' to propofol is not completely understood. The purpose of this study was to evaluate the effect of propofol on myocardial performance in rats with obstructive jaundice. METHODS: Male Sprague-Dawley rats (n = 40) were randomly allocated into two groups, twenty underwent bile duct ligation (BDL), and 20 underwent a sham operation. Seven days after the surgery, propofol was administered in vivo and ex vivo (Langendorff preparations). Heart rate, left ventricular end-systolic pressure (LVESP) left ventricular end-diastolic pressure (LVEDP), and maximal rate for left ventricular pressure rise and decline (+/- dP/dtmax ) were measured to determine the influence of propofol on the cardiac function of rats. RESULTS: Impaired basal cardiac function was observed in the isolated BDL hearts, whereas in vivo indices of basal cardiac function (LVESP and +/- dP/dt) in vivo were significantly higher in rats that underwent BDL compared with controls. With low or intermediate concentrations of propofol, these indices of cardiac function were within the normal physiologic range in both groups, and responsiveness to propofol was unaffected by BDL. When the highest concentration of propofol was administrated, a significant decline in cardiac function was observed in the BDL group. CONCLUSIONS: In rats that underwent BDL, basal cardiac performance was better in vivo and worse ex vivo compared with controls. Low and intermediate concentrations of propofol did not appear to impair cardiac function in rats with obstructive jaundice.
Persistent Identifierhttp://hdl.handle.net/10722/177332
ISSN
2015 Impact Factor: 2.101
2015 SCImago Journal Rankings: 0.999
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRen, HMen_US
dc.contributor.authorYang, LQen_US
dc.contributor.authorLiu, ZQen_US
dc.contributor.authorChen, CYen_US
dc.contributor.authorCheung, CWen_US
dc.contributor.authorTao, KMen_US
dc.contributor.authorSong, JGen_US
dc.contributor.authorChen, WRen_US
dc.contributor.authorYu, WFen_US
dc.date.accessioned2012-12-18T05:01:45Z-
dc.date.available2012-12-18T05:01:45Z-
dc.date.issued2011en_US
dc.identifier.citationBMC Gastroenterology, 2011, v. 11, article no. 144en_US
dc.identifier.issn1471-230X-
dc.identifier.urihttp://hdl.handle.net/10722/177332-
dc.description.abstractBACKGROUND: Responsiveness of the 'jaundiced heart' to propofol is not completely understood. The purpose of this study was to evaluate the effect of propofol on myocardial performance in rats with obstructive jaundice. METHODS: Male Sprague-Dawley rats (n = 40) were randomly allocated into two groups, twenty underwent bile duct ligation (BDL), and 20 underwent a sham operation. Seven days after the surgery, propofol was administered in vivo and ex vivo (Langendorff preparations). Heart rate, left ventricular end-systolic pressure (LVESP) left ventricular end-diastolic pressure (LVEDP), and maximal rate for left ventricular pressure rise and decline (+/- dP/dtmax ) were measured to determine the influence of propofol on the cardiac function of rats. RESULTS: Impaired basal cardiac function was observed in the isolated BDL hearts, whereas in vivo indices of basal cardiac function (LVESP and +/- dP/dt) in vivo were significantly higher in rats that underwent BDL compared with controls. With low or intermediate concentrations of propofol, these indices of cardiac function were within the normal physiologic range in both groups, and responsiveness to propofol was unaffected by BDL. When the highest concentration of propofol was administrated, a significant decline in cardiac function was observed in the BDL group. CONCLUSIONS: In rats that underwent BDL, basal cardiac performance was better in vivo and worse ex vivo compared with controls. Low and intermediate concentrations of propofol did not appear to impair cardiac function in rats with obstructive jaundice.-
dc.languageengen_US
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcgastroenterol/-
dc.relation.ispartofBMC Gastroenterologyen_US
dc.rightsBMC Gastroenterology. Copyright © BioMed Central Ltd.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAnesthetics, Intravenous - pharmacology-
dc.subject.meshHeart Rate - drug effects-
dc.subject.meshJaundice, Obstructive - complications-
dc.subject.meshMyocardial Contraction - drug effects-
dc.subject.meshPropofol - pharmacology-
dc.titleIn vivo and ex vivo effects of propofol on myocardial performance in rats with obstructive jaundiceen_US
dc.typeArticleen_US
dc.identifier.emailCheung, CW: cheucw01@netvigator.com, cheucw@hku.hken_US
dc.identifier.authorityCheung, CW=rp00244en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/1471-230X-11-144-
dc.identifier.pmid22204383-
dc.identifier.pmcidPMC3276443-
dc.identifier.scopuseid_2-s2.0-84455173833-
dc.identifier.hkuros204266en_US
dc.identifier.hkuros215337-
dc.identifier.volume11, article no. 144en_US
dc.identifier.isiWOS:000300149800001-
dc.publisher.placeUnited Kingdom-
dc.identifier.citeulike10186195-

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