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Article: Strontium incorporated coralline hydroxyapatite for engineering bone

TitleStrontium incorporated coralline hydroxyapatite for engineering bone
Authors
Issue Date2013
PublisherHindawi Publishing Corporation.
Citation
ISRN Biomaterials, 2013, v. 2013, p. Article ID. 649163, 1-11 How to Cite?
AbstractGoniopora was hydrothermally converted to coralline hydroxyapatite (CHA) and incorporated with Sr (Sr-CHA). The pore size of Goniopora was in the range of 40–300 μm with a porosity of about 68%. Surface morphologies of the coral were modified to flake-like hydroxyapatite structures on CHA and the addition of Sr detected on Sr-CHA as confirmed by SEM and EDX. As the first report of incorporating Sr into coral, about 6%–14% Sr was detected on Sr-CHA. The compressive strengths of CHA and Sr-CHA were not compromised due to the hydrothermal treatments. Sr-CHA was studied in vitro using MC3T3-E1 cells and in vivo with an ovariectomized rat model. The proliferation of MC3T3-E1 cells was significantly promoted by Sr-CHA as compared to CHA. Moreover, higher scaffold volume retention (+40%) was reported on the micro-CT analysis of the Sr-CHA scaffold. The results suggest that the incorporation of Sr in CHA can further enhance the osteoconductivity and osteoinductivity of corals. Strontium has been suggested to stimulate bone growth and inhibit bone resorption. In this study, we have successfully incorporated Sr into CHA with the natural porous structure remained and explored the idea of Sr-CHA as a potential scaffolding material for bone regeneration.
Persistent Identifierhttp://hdl.handle.net/10722/177324
ISSN

 

DC FieldValueLanguage
dc.contributor.authorLiu, W-
dc.contributor.authorWang, T-
dc.contributor.authorShen, Y-
dc.contributor.authorPan, H-
dc.contributor.authorPeng, S-
dc.contributor.authorLu, WW-
dc.date.accessioned2012-12-14T01:51:21Z-
dc.date.available2012-12-14T01:51:21Z-
dc.date.issued2013-
dc.identifier.citationISRN Biomaterials, 2013, v. 2013, p. Article ID. 649163, 1-11-
dc.identifier.issn2314-4025-
dc.identifier.urihttp://hdl.handle.net/10722/177324-
dc.description.abstractGoniopora was hydrothermally converted to coralline hydroxyapatite (CHA) and incorporated with Sr (Sr-CHA). The pore size of Goniopora was in the range of 40–300 μm with a porosity of about 68%. Surface morphologies of the coral were modified to flake-like hydroxyapatite structures on CHA and the addition of Sr detected on Sr-CHA as confirmed by SEM and EDX. As the first report of incorporating Sr into coral, about 6%–14% Sr was detected on Sr-CHA. The compressive strengths of CHA and Sr-CHA were not compromised due to the hydrothermal treatments. Sr-CHA was studied in vitro using MC3T3-E1 cells and in vivo with an ovariectomized rat model. The proliferation of MC3T3-E1 cells was significantly promoted by Sr-CHA as compared to CHA. Moreover, higher scaffold volume retention (+40%) was reported on the micro-CT analysis of the Sr-CHA scaffold. The results suggest that the incorporation of Sr in CHA can further enhance the osteoconductivity and osteoinductivity of corals. Strontium has been suggested to stimulate bone growth and inhibit bone resorption. In this study, we have successfully incorporated Sr into CHA with the natural porous structure remained and explored the idea of Sr-CHA as a potential scaffolding material for bone regeneration.-
dc.languageeng-
dc.publisherHindawi Publishing Corporation.-
dc.relation.ispartofISRN Biomaterials-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsCopyright © 2012 Waiching Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.-
dc.titleStrontium incorporated coralline hydroxyapatite for engineering boneen_US
dc.typeArticleen_US
dc.identifier.emailPan, H: haobo@hku.hk-
dc.identifier.emailLu, WW: wwlu@hkusua.hku.hk-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.5402/2013/649163-
dc.identifier.volume2013-
dc.identifier.spageArticle ID. 649163, 1-
dc.identifier.epageArticle ID. 649163, 11-
dc.publisher.placeUnited States-

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