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Article: Poisoning with illicit substances: toxicology for the anaesthetist

TitlePoisoning with illicit substances: toxicology for the anaesthetist
Authors
Issue Date2013
PublisherChurchill Livingstone.
Citation
Anaesthesia, 2013, v. 68 n. S1, p. 117-124 How to Cite?
AbstractThe consumption of illicit substances represents a considerable threat to the health and wellbeing of particular sectors of our communities. Hospitalisation is sometimes required for the treatment of the direct toxic effects of the drugs as well as for injuries sustained while under their influence. Although poisoning with ‘traditional‘ substances of abuse such as opioids, cocaine and cannabis still predominate in terms of numbers, the availability and use of new psychoactive substances are on the rise. These latter agents, some of which began life as failed pharmaceutical products, have enjoyed renewed status as recreational stimulants, entactogens or hallucinogens, properties that originally precluded them from legitimate use. These drugs may act by enhancing endogenous release of neurotransmitters, inhibiting their reuptake back into neurons or having direct effects on receptors, and may involve adrenergic, dopaminergic or serotonergic systems. The use of intravenous lipid emulsion for the symptomatic treatment of drug overdose has become a fertile ground for research and may hold promise as a non-specific treatment for poisoning with illicit substances. Dexmedetomidine, an α2-receptor agonist with a central sympatholytic effect, may be able to counteract the cardiovascular and central nervous system overstimulation that may accompany stimulant toxicity.
Persistent Identifierhttp://hdl.handle.net/10722/177318
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, GTC-
dc.contributor.authorIrwin, MG-
dc.date.accessioned2012-12-11T08:08:46Z-
dc.date.available2012-12-11T08:08:46Z-
dc.date.issued2013-
dc.identifier.citationAnaesthesia, 2013, v. 68 n. S1, p. 117-124-
dc.identifier.issn0263-1512-
dc.identifier.urihttp://hdl.handle.net/10722/177318-
dc.description.abstractThe consumption of illicit substances represents a considerable threat to the health and wellbeing of particular sectors of our communities. Hospitalisation is sometimes required for the treatment of the direct toxic effects of the drugs as well as for injuries sustained while under their influence. Although poisoning with ‘traditional‘ substances of abuse such as opioids, cocaine and cannabis still predominate in terms of numbers, the availability and use of new psychoactive substances are on the rise. These latter agents, some of which began life as failed pharmaceutical products, have enjoyed renewed status as recreational stimulants, entactogens or hallucinogens, properties that originally precluded them from legitimate use. These drugs may act by enhancing endogenous release of neurotransmitters, inhibiting their reuptake back into neurons or having direct effects on receptors, and may involve adrenergic, dopaminergic or serotonergic systems. The use of intravenous lipid emulsion for the symptomatic treatment of drug overdose has become a fertile ground for research and may hold promise as a non-specific treatment for poisoning with illicit substances. Dexmedetomidine, an α2-receptor agonist with a central sympatholytic effect, may be able to counteract the cardiovascular and central nervous system overstimulation that may accompany stimulant toxicity.-
dc.languageeng-
dc.publisherChurchill Livingstone.-
dc.relation.ispartofAnaesthesia-
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Anaesthesia. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Anaesthesia, [VOL 68, ISSUE S1, 2013] DOI 10.1111/anae.12053-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titlePoisoning with illicit substances: toxicology for the anaesthetisten_US
dc.typeArticleen_US
dc.identifier.emailWong, GTC: gordontcwong@hotmail.com-
dc.identifier.emailIrwin, MG: mgirwin@hkucc.hku.hk-
dc.description.naturepostprint-
dc.identifier.doi10.1111/anae.12053-
dc.identifier.pmid23210561-
dc.identifier.scopuseid_2-s2.0-84872896088-
dc.identifier.volume68-
dc.identifier.issueS1-
dc.identifier.spage117-
dc.identifier.epage124-
dc.identifier.isiWOS:000311974900011-
dc.publisher.placeUnited Kingdom-

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