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Article: Differential Aqueous and Vitreous Concentrations of Moxifloxacin and Ofloxacin After Topical Administration One Hour before Vitrectomy

TitleDifferential Aqueous and Vitreous Concentrations of Moxifloxacin and Ofloxacin After Topical Administration One Hour before Vitrectomy
Authors
Issue Date2007
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajo
Citation
American Journal Of Ophthalmology, 2007, v. 144 n. 2, p. 315-318 How to Cite?
AbstractPurpose: To investigate the penetration of ofloxacin and moxifloxacin into the aqueous and vitreous after topical administration one hour before vitrectomy surgery. Design: Prospective, randomized, double-blind case series study. Methods: Twenty-seven patients undergoing vitrectomy were randomized to receive either topical ofloxacin 0.3% or moxifloxacin 0.5% every 10 minutes for one hour before surgery. Aqueous and vitreous samples were obtained and analyzed using high-performance liquidation chromatography. Results: The moxifloxacin aqueous (1.576 ± 0.745 μg/ml) and vitreous (0.225 ± 0.013 μg/ml) levels were significantly higher than the ofloxacin aqueous (0.816 ± 0.504 μg/ml) (P = .0009) and vitreous (0.225 ± 0.013 μg/ml) [P = .0054] levels, respectively. The mean moxifloxacin aqueous and vitreous levels exceeded the minimum inhibitory concentration for 90% of isolates (MIC 90) for a wide variety of bacteria implicated in endophthalmitis. In contrast, the aqueous level of ofloxacin exceeded the MIC 90 of only a few organisms. Conclusions: Moxifloxacin applied every 10 minutes during the hour before vitrectomy penetrated the eye significantly better than ofloxacin. © 2007 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/176465
ISSN
2015 Impact Factor: 3.831
2015 SCImago Journal Rankings: 2.803
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLai, WWen_US
dc.contributor.authorChu, KOen_US
dc.contributor.authorChan, KPen_US
dc.contributor.authorChoy, KWen_US
dc.contributor.authorWang, CCen_US
dc.contributor.authorTsang, CWen_US
dc.contributor.authorPang, CPen_US
dc.date.accessioned2012-11-26T09:11:37Z-
dc.date.available2012-11-26T09:11:37Z-
dc.date.issued2007en_US
dc.identifier.citationAmerican Journal Of Ophthalmology, 2007, v. 144 n. 2, p. 315-318en_US
dc.identifier.issn0002-9394en_US
dc.identifier.urihttp://hdl.handle.net/10722/176465-
dc.description.abstractPurpose: To investigate the penetration of ofloxacin and moxifloxacin into the aqueous and vitreous after topical administration one hour before vitrectomy surgery. Design: Prospective, randomized, double-blind case series study. Methods: Twenty-seven patients undergoing vitrectomy were randomized to receive either topical ofloxacin 0.3% or moxifloxacin 0.5% every 10 minutes for one hour before surgery. Aqueous and vitreous samples were obtained and analyzed using high-performance liquidation chromatography. Results: The moxifloxacin aqueous (1.576 ± 0.745 μg/ml) and vitreous (0.225 ± 0.013 μg/ml) levels were significantly higher than the ofloxacin aqueous (0.816 ± 0.504 μg/ml) (P = .0009) and vitreous (0.225 ± 0.013 μg/ml) [P = .0054] levels, respectively. The mean moxifloxacin aqueous and vitreous levels exceeded the minimum inhibitory concentration for 90% of isolates (MIC 90) for a wide variety of bacteria implicated in endophthalmitis. In contrast, the aqueous level of ofloxacin exceeded the MIC 90 of only a few organisms. Conclusions: Moxifloxacin applied every 10 minutes during the hour before vitrectomy penetrated the eye significantly better than ofloxacin. © 2007 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajoen_US
dc.relation.ispartofAmerican Journal of Ophthalmologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAnti-Infective Agents - Administration & Dosage - Pharmacokineticsen_US
dc.subject.meshAqueous Humor - Metabolismen_US
dc.subject.meshAza Compounds - Administration & Dosage - Pharmacokineticsen_US
dc.subject.meshBiological Availabilityen_US
dc.subject.meshChromatography, High Pressure Liquiden_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMicrobial Sensitivity Testsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOfloxacin - Administration & Dosage - Pharmacokineticsen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshQuinolines - Administration & Dosage - Pharmacokineticsen_US
dc.subject.meshRetinal Diseases - Surgeryen_US
dc.subject.meshVitrectomyen_US
dc.subject.meshVitreous Body - Metabolismen_US
dc.titleDifferential Aqueous and Vitreous Concentrations of Moxifloxacin and Ofloxacin After Topical Administration One Hour before Vitrectomyen_US
dc.typeArticleen_US
dc.identifier.emailLai, WW: wicolai@hku.hken_US
dc.identifier.authorityLai, WW=rp00531en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ajo.2007.03.036en_US
dc.identifier.pmid17659971-
dc.identifier.scopuseid_2-s2.0-34447632482en_US
dc.identifier.hkuros144387-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34447632482&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume144en_US
dc.identifier.issue2en_US
dc.identifier.spage315en_US
dc.identifier.epage318en_US
dc.identifier.isiWOS:000248521800033-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLai, WW=7402231098en_US
dc.identifier.scopusauthoridChu, KO=7402453672en_US
dc.identifier.scopusauthoridChan, KP=35336016800en_US
dc.identifier.scopusauthoridChoy, KW=7005477052en_US
dc.identifier.scopusauthoridWang, CC=8859335700en_US
dc.identifier.scopusauthoridTsang, CW=17342808000en_US
dc.identifier.scopusauthoridPang, CP=24423687500en_US

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