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Article: Latanoprost versus timolol gel to prevent ocular hypertension after phacoemulsification and intraocular lens implantation

TitleLatanoprost versus timolol gel to prevent ocular hypertension after phacoemulsification and intraocular lens implantation
Authors
Issue Date2000
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jcrs
Citation
Journal Of Cataract And Refractive Surgery, 2000, v. 26 n. 3, p. 386-391 How to Cite?
AbstractPurpose: To evaluate the efficacy of latanoprost and timolol gel in preventing ocular hypertension in the early period after phacoemulsification and posterior chamber intraocular lens (PC IOL) implantation. Setting: Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, China. Methods: This prospective randomized double-masked clinical trial comprised patients with uncomplicated cataract having phacoemulsification with PC IOL implantation. They were randomly assigned to 1 of 3 groups: postoperative application of timolol 0.5% gel-forming solution (Timoptol-XE®) (Group 1), latanoprost 0.005% (Group 2), and control (Group 3). Intraocular pressure (IOP) was measured 2, 4, and 24 hours postoperatively. The anterior chamber was examined for the levels of cells and flare using slitlamp biomicroscopy. Results: Group 1 had a significantly greater reduction in mean IOP 2, 4, and 24 hours after phacoemulsification and PC IOL implantation than Group 3 (P < .05). There were no significant differences between Groups 2 and 3 at any interval (P > .05). No excessive postoperative anterior chamber inflammation was observed in any group. Conclusions: A single dose of latanoprost given after phacoemulsification and PC IOL implantation did not produce a significant IOP-lowering effect when compared with a control group in the first 24 hours postoperatively. A single dose of timolol gel produced a significant postoperative IOP decrease as soon as 2 hours and up to 24 hours after surgery. Timolol gel and latanoprost are safe, but timolol is more effective than latanoprost in preventing postoperative ocular hypertension. (C) 2000 ASCRS and ESCRS.
Persistent Identifierhttp://hdl.handle.net/10722/176364
ISSN
2015 Impact Factor: 3.02
2015 SCImago Journal Rankings: 1.946
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLai, JSMen_US
dc.contributor.authorChua, JKHen_US
dc.contributor.authorLeung, ATSen_US
dc.contributor.authorLam, DSCen_US
dc.date.accessioned2012-11-26T09:10:50Z-
dc.date.available2012-11-26T09:10:50Z-
dc.date.issued2000en_US
dc.identifier.citationJournal Of Cataract And Refractive Surgery, 2000, v. 26 n. 3, p. 386-391en_US
dc.identifier.issn0886-3350en_US
dc.identifier.urihttp://hdl.handle.net/10722/176364-
dc.description.abstractPurpose: To evaluate the efficacy of latanoprost and timolol gel in preventing ocular hypertension in the early period after phacoemulsification and posterior chamber intraocular lens (PC IOL) implantation. Setting: Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Hong Kong, China. Methods: This prospective randomized double-masked clinical trial comprised patients with uncomplicated cataract having phacoemulsification with PC IOL implantation. They were randomly assigned to 1 of 3 groups: postoperative application of timolol 0.5% gel-forming solution (Timoptol-XE®) (Group 1), latanoprost 0.005% (Group 2), and control (Group 3). Intraocular pressure (IOP) was measured 2, 4, and 24 hours postoperatively. The anterior chamber was examined for the levels of cells and flare using slitlamp biomicroscopy. Results: Group 1 had a significantly greater reduction in mean IOP 2, 4, and 24 hours after phacoemulsification and PC IOL implantation than Group 3 (P < .05). There were no significant differences between Groups 2 and 3 at any interval (P > .05). No excessive postoperative anterior chamber inflammation was observed in any group. Conclusions: A single dose of latanoprost given after phacoemulsification and PC IOL implantation did not produce a significant IOP-lowering effect when compared with a control group in the first 24 hours postoperatively. A single dose of timolol gel produced a significant postoperative IOP decrease as soon as 2 hours and up to 24 hours after surgery. Timolol gel and latanoprost are safe, but timolol is more effective than latanoprost in preventing postoperative ocular hypertension. (C) 2000 ASCRS and ESCRS.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jcrsen_US
dc.relation.ispartofJournal of Cataract and Refractive Surgeryen_US
dc.subject.meshAdrenergic Beta-Antagonists - Administration & Dosageen_US
dc.subject.meshAgeden_US
dc.subject.meshAnterior Chamber - Pathologyen_US
dc.subject.meshAntihypertensive Agents - Administration & Dosageen_US
dc.subject.meshCell Counten_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshFemaleen_US
dc.subject.meshGelsen_US
dc.subject.meshHumansen_US
dc.subject.meshIntraocular Pressure - Drug Effectsen_US
dc.subject.meshLens Implantation, Intraocular - Adverse Effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshOcular Hypertension - Etiology - Pathology - Prevention & Controlen_US
dc.subject.meshPhacoemulsification - Adverse Effectsen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshProstaglandins F, Synthetic - Administration & Dosageen_US
dc.subject.meshTimolol - Administration & Dosageen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleLatanoprost versus timolol gel to prevent ocular hypertension after phacoemulsification and intraocular lens implantationen_US
dc.typeArticleen_US
dc.identifier.emailLai, JSM: laism@hku.hken_US
dc.identifier.authorityLai, JSM=rp00295en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0886-3350(99)00364-8en_US
dc.identifier.pmid10713234-
dc.identifier.scopuseid_2-s2.0-0034017640en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034017640&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume26en_US
dc.identifier.issue3en_US
dc.identifier.spage386en_US
dc.identifier.epage391en_US
dc.identifier.isiWOS:000085768000023-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLai, JSM=7401939748en_US
dc.identifier.scopusauthoridChua, JKH=7005163724en_US
dc.identifier.scopusauthoridLeung, ATS=7403012621en_US
dc.identifier.scopusauthoridLam, DSC=35500200200en_US

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